1,573 research outputs found
Asymptotic safety guaranteed in supersymmetry
We explain how asymptotic safety arises in four-dimensional supersymmetric gauge theories. We provide asymptotically safe supersymmetric gauge theories together with their superconformal fixed points, R charges, phase diagrams, and UV-IR connecting trajectories. Strict perturbative control is achieved in a Veneziano limit. Consistency with unitarity and the a theorem is established. We find that supersymmetry enhances the predictivity of asymptotically safe theories
Cosmological Constant, Dark Matter, and Electroweak Phase Transition
Accepting the fine tuned cosmological constant hypothesis, we have recently
proposed that this hypothesis can be tested if the dark matter freeze out
occurs at the electroweak scale and if one were to measure an anomalous shift
in the dark matter relic abundance. In this paper, we numerically compute this
relic abundance shift in the context of explicit singlet extensions of the
Standard Model and explore the properties of the phase transition which would
lead to the observationally most favorable scenario. Through the numerical
exploration, we explicitly identify a parameter space in a singlet extension of
the standard model which gives order unity observable effects. We also clarify
the notion of a temperature dependence in the vacuum energy.Comment: 58 pages, 10 figure
Segmentation of Endothelial Cell Boundaries of Rabbit Aortic Images Using a Machine Learning Approach
This paper presents an automatic detection method for thin boundaries of silver-stained endothelial cells (ECs) imaged using light microscopy of endothelium mono-layers from rabbit aortas. To achieve this, a segmentation technique was developed, which relies on a rich feature space to describe the spatial neighbourhood of each pixel and employs a Support Vector Machine (SVM) as a classifier. This segmentation approach is compared, using hand-labelled data, to a number of standard segmentation/thresholding methods commonly applied in microscopy. The importance of different features is also assessed using the method of minimum Redundancy, Maximum Relevance (mRMR), and the effect of different SVM kernels is also considered. The results show that the approach suggested in this paper attains much greater accuracy than standard techniques; in our comparisons with manually labelled data, our proposed technique is able to identify boundary pixels to an accuracy of 93%. More significantly, out of a set of 56 regions of image data, 43 regions were binarised to a useful level of accuracy. The results obtained from the image segmentation technique developed here may be used for the study of shape and alignment of ECs, and hence patterns of blood flow, around arterial branches
Measuring Stellar Radial Velocities with a Dispersed Fixed-Delay Interferometer
We demonstrate the ability to measure precise stellar barycentric radial
velocities with the dispersed fixed-delay interferometer technique using the
Exoplanet Tracker (ET), an instrument primarily designed for precision
differential Doppler velocity measurements using this technique. Our
barycentric radial velocities, derived from observations taken at the KPNO 2.1
meter telescope, differ from those of Nidever et al. by 0.047 km/s (rms) when
simultaneous iodine calibration is used, and by 0.120 km/s (rms) without
simultaneous iodine calibration. Our results effectively show that a Michelson
interferometer coupled to a spectrograph allows precise measurements of
barycentric radial velocities even at a modest spectral resolution of R ~ 5100.
A multi-object version of the ET instrument capable of observing ~500 stars per
night is being used at the Sloan 2.5 m telescope at Apache Point Observatory
for the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS),
a wide-field radial velocity survey for extrasolar planets around TYCHO-2 stars
in the magnitude range 7.6<V<12. In addition to precise differential
velocities, this survey will also yield precise barycentric radial velocities
for many thousands of stars using the data analysis techniques reported here.
Such a large kinematic survey at high velocity precision will be useful in
identifying the signature of accretion events in the Milky Way and
understanding local stellar kinematics in addition to discovering exoplanets,
brown dwarfs and spectroscopic binaries.Comment: 9 pages, 4 figures. Accepted for publication in Ap
Effective Field Theory, Black Holes, and the Cosmological Constant
Bekenstein has proposed the bound S < pi M_P^2 L^2 on the total entropy S in
a volume L^3. This non-extensive scaling suggests that quantum field theory
breaks down in large volume. To reconcile this breakdown with the success of
local quantum field theory in describing observed particle phenomenology, we
propose a relationship between UV and IR cutoffs such that an effective field
theory should be a good description of Nature. We discuss implications for the
cosmological constant problem. We find a limitation on the accuracy which can
be achieved by conventional effective field theory: for example, the minimal
correction to (g-2) for the electron from the constrained IR and UV cutoffs is
larger than the contribution from the top quark.Comment: 5 pages, no figures minor clarifications, refs adde
Time-reversal symmetry breaking in circuit-QED based photon lattices
Breaking time-reversal symmetry is a prerequisite for accessing certain
interesting many-body states such as fractional quantum Hall states. For
polaritons, charge neutrality prevents magnetic fields from providing a direct
symmetry breaking mechanism and similar to the situation in ultracold atomic
gases, an effective magnetic field has to be synthesized. We show that in the
circuit QED architecture, this can be achieved by inserting simple
superconducting circuits into the resonator junctions. In the presence of such
coupling elements, constant parallel magnetic and electric fields suffice to
break time-reversal symmetry. We support these theoretical predictions with
numerical simulations for realistic sample parameters, specify general
conditions under which time-reversal is broken, and discuss the application to
chiral Fock state transfer, an on-chip circulator, and tunable band structure
for the Kagome lattice.Comment: minor revisions, version published in PRA; 19 pages, 13 figures, 2
table
CD25 expression distinguishes functionally distinct alloreactive CD4+ CD134+ (OX40+) T-cell subsets in acute graft-versus-host disease
AbstractCD134 (OX40) is expressed on activated CD4+ donor T cells in allogeneic stem cell transplant recipients with acute graft-versus-host disease. The data presented here reveal that differential expression of CD25 by CD4+ CD134+ T cells allows separation of these activated cells into 2 phenotypically and functionally distinct alloreactive T-cell subsets. These subsets exhibit distinct tissue associations, with CD4+ CD134+ CD25− T cells preferentially found in lymphoid tissues and CD4+ CD134+ CD25+ T cells located in lymphoid tissues and inflamed extralymphoid tissues. The CD25− T-cell subset exhibited potent proliferative responses to both concanavalin A and allogeneic host leukocytes. By contrast, the CD25+ T-cell subset proliferated minimally in response to either treatment and inhibited alloantigen-induced proliferation of the CD25− subset. Proliferative unresponsiveness associated with the CD25+ T-cell subset did not extend to cytokine secretion. When stimulated with alloantigen, both CD4+ CD134+ T-cell subsets responded by secreting interferon-γ and interleukin (IL)-10, and neither T-cell subset produced detectable levels of IL-2 or IL-4. Three-day treatment of the CD25+ T-cell subset with IL-2 restored the proliferative responsiveness of these cells to host alloantigens, suggesting that the proliferative unresponsiveness associated with this T-cell subset reflected a requirement for IL-2. The preferential tissue associations and distinct functional properties associated with these separable alloreactive CD4+ CD134+ T-cell subsets suggest that they participate differentially in clinical graft-versus-host disease
An RNAi Screen for Genes Required for Growth of Drosophila Wing Tissue
Cell division and tissue growth must be coordinated with development. Defects in these processes are the basis for a number of diseases, including developmental malformations and cancer. We have conducted an unbiased RNAi screen for genes that are required for growth in the Drosophila wing, using GAL4-inducible short hairpin RNA (shRNA) fly strains made by the Drosophila RNAi Screening Center. shRNA expression down the center of the larval wing disc using dpp-GAL4, and the central region of the adult wing was then scored for tissue growth and wing hair morphology. Out of 4,753 shRNA crosses that survived to adulthood, 18 had impaired wing growth. FlyBase and the new Alliance of Genome Resources knowledgebases were used to determine the known or predicted functions of these genes and the association of their human orthologs with disease. The function of eight of the genes identified has not been previously defined in Drosophila The genes identified included those with known or predicted functions in cell cycle, chromosome segregation, morphogenesis, metabolism, steroid processing, transcription, and translation. All but one of the genes are similar to those in humans, and many are associated with disease. Knockdown of lin-52, a subunit of the Myb-MuvB transcription factor, or βNACtes6, a gene involved in protein folding and trafficking, resulted in a switch from cell proliferation to an endoreplication growth program through which wing tissue grew by an increase in cell size (hypertrophy). It is anticipated that further analysis of the genes that we have identified will reveal new mechanisms that regulate tissue growth during development
The COS-Dwarfs Survey: The Carbon Reservoir Around sub-L* Galaxies
We report new observations of circumgalactic gas from the COS-Dwarfs survey,
a systematic investigation of the gaseous halos around 43 low-mass z 0.1
galaxies using background QSOs observed with the Cosmic Origins Spectrograph.
From the projected 1D and 2D distribution of C IV absorption, we find that C IV
absorption is detected out to ~ 0.5 R of the host galaxies. The C IV
absorption strength falls off radially as a power law and beyond 0.5 R,
no C IV absorption is detected above our sensitivity limit of ~ 50-100 m.
We find a tentative correlation between detected C IV absorption strength and
star formation, paralleling the strong correlation seen in highly ionized
oxygen for L~L* galaxies by the COS-Halos survey. The data imply a large carbon
reservoir in the CGM of these galaxies, corresponding to a minimum carbon mass
of 1.2 out to ~ 110 kpc. This mass is
comparable to the carbon mass in the ISM and more than the carbon mass
currently in stars of these galaxies. The C IV absorption seen around these
sub-L* galaxies can account for almost two-thirds of all > 100 m C IV
absorption detected at low z. Comparing the C IV covering fraction with
hydrodynamical simulations, we find that an energy-driven wind model is
consistent with the observations whereas a wind model of constant velocity
fails to reproduce the CGM or the galaxy properties.Comment: 18 Pages, 11 Figures, ApJ 796 13
The COS-Halos Survey: Physical Conditions and Baryonic Mass in the Low-Redshift Circumgalactic Medium
We analyze the physical conditions of the cool, photoionized (T
K) circumgalactic medium (CGM) using the COS-Halos suite of gas column density
measurements for 44 gaseous halos within 160 kpc of galaxies at . These data are well described by simple photoionization models, with
the gas highly ionized (n/n) by the
extragalactic ultraviolet background (EUVB). Scaling by estimates for the
virial radius, R, we show that the ionization state (tracked by the
dimensionless ionization parameter, U) increases with distance from the host
galaxy. The ionization parameters imply a decreasing volume density profile
n = (10)(R/R. Our derived
gas volume densities are several orders of magnitude lower than predictions
from standard two-phase models with a cool medium in pressure equilibrium with
a hot, coronal medium expected in virialized halos at this mass scale. Applying
the ionization corrections to the HI column densities, we estimate a lower
limit to the cool gas mass M
M for the volume within R R. Allowing for an
additional warm-hot, OVI-traced phase, the CGM accounts for at least half of
the baryons purported to be missing from dark matter halos at the 10
M scale.Comment: 19 pages, 12 Figures, and a 37-page Appendix with 36 additional
figures. Accepted to ApJ June 21 201
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