Far From Value-Free: How a Value-Centered Scientific Pluralism Bolsters the Cognitive Credentials of Science

The value-free ideal for science (VFI) prohibits noncognitive values (e.g., social or religious values) from influencing the practice of science. After all, a scientist should not reject an empirical theory (e.g.) on religious grounds. But while motivated by reasonable concerns, VFI overlooks legitimate roles for noncognitive values in science. Contra VFI, Hugh Lacey explains that noncognitive values can promote scientific aims by grounding new methodologies that may lead to novel theories and extend to new domains. Yet, Lacey agrees with one aspect of VFI: noncognitive values should not serve as grounds in the empirical evaluation of theories. This has led some critics to misidentify his view merely as an updated version of VFI. I argue that views of the kind Lacey endorses, which I call Dialectical Empiricism (DE), deserve further investigation. They capture what VFI gets right; but they also show that noncognitive values are essential to good science. Throughout the dissertation I explore variants of DE, demonstrating its potential and flexibility. Furthermore, I defend DE against its critics, especially those who mistake it for a version of VFI. In stark opposition to VFI, DE reveals how the illusion of value-freedom sometimes blinds us to promising alternatives to mainstream scientific approaches. I demonstrate this by applying the framework of DE to contemporary research in agricultural and nutritional science. These case studies show that noncognitive values really do influence scientific practices. And, most importantly, they demonstrate how embracing a value-laden view of science can open our eyes to promising alternative approaches that may have the potential to increase our knowledge of the world and of possibilities for human flourishing

MEMS 411: Fast Pill Cutter

This design project attempted to create a new pill-cutting device to help pharmacy technicians split pills quickly, precisely, and safely. The product was intended to occupy a competitive niche with current devices on the market, prioritizing increased cutting speed with potentially greater cost

ElectroLens: Understanding Atomistic Simulations Through Spatially-resolved Visualization of High-dimensional Features

In recent years, machine learning (ML) has gained significant popularity in the field of chemical informatics and electronic structure theory. These techniques often require researchers to engineer abstract "features" that encode chemical concepts into a mathematical form compatible with the input to machine-learning models. However, there is no existing tool to connect these abstract features back to the actual chemical system, making it difficult to diagnose failures and to build intuition about the meaning of the features. We present ElectroLens, a new visualization tool for high-dimensional spatially-resolved features to tackle this problem. The tool visualizes high-dimensional data sets for atomistic and electron environment features by a series of linked 3D views and 2D plots. The tool is able to connect different derived features and their corresponding regions in 3D via interactive selection. It is built to be scalable, and integrate with existing infrastructure.Comment: accepted to IEEE visualization 2019 conferenc

Wake Instabilities Behind Discrete Roughness Elements in High Speed Boundary Layers

Computations are performed to study the flow past an isolated, spanwise symmetric roughness element in zero pressure gradient boundary layers at Mach 3.5 and 5.9, with an emphasis on roughness heights of less than 55 percent of the local boundary layer thickness. The Mach 5.9 cases include flow conditions that are relevant to both ground facility experiments and high altitude flight ("cold wall" case). Regardless of the Mach number, the mean flow distortion due to the roughness element is characterized by long-lived streamwise streaks in the roughness wake, which can support instability modes that did not exist in the absence of the roughness element. The higher Mach number cases reveal a variety of instability mode shapes with velocity fluctuations concentrated in different localized regions of high base flow shear. The high shear regions vary from the top of a mushroom shaped structure characterizing the centerline streak to regions that are concentrated on the sides of the mushroom. Unlike the Mach 3.5 case with nearly same values of scaled roughness height k/delta and roughness height Reynolds number Re(sub kk), the odd wake modes in both Mach 5.9 cases are significantly more unstable than the even modes of instability. Additional computations for a Mach 3.5 boundary layer indicate that the presence of a roughness element can also enhance the amplification of first mode instabilities incident from upstream. Interactions between multiple roughness elements aligned along the flow direction are also explored

On N=2 strings and classical scattering solutions of self-dual Yang-Mills in (2,2) spacetime

Ooguri and Vafa have shown that the open N=2 string corresponds to self-dual Yang-Mills (SDYM) and also that, in perturbation theory, it has has a vanishing four particle scattering amplitude. We discuss how the dynamics of the three particle scattering implies that on shell states can only scatter if their momenta lie in the same self-dual plane and then investigate classical SDYM with the aim of comparing exact solutions with the tree level perturbation theory predictions. In particular for the gauge group SL(2,C) with a plane wave Hirota ansatz SDYM reduces to a complicated set of algebraic relations due to de Vega. Here we solve these conditions and the solutions are shown to correspond to collisions of plane wave kinks. The main result is that for a class of kinks the resulting phase shifts are non-zero, the solution as a whole is not pure gauge and so the scattering seems non-trivial. However the stress energy and Lagrangian density are confined to string like regions in the space time and in particular are zero for the incoming/outgoing kinks so the solution does not correspond to physical four point scattering.Comment: 20 page

The UK Cardiac and Vascular Surgery Interventional Anaemia Response (CAVIAR) Study: protocol for an observational cohort study to determine the impact and effect of preoperative anaemia management in cardiac and vascular surgical patients.

INTRODUCTION: Preoperative anaemia is linked to poor postsurgical outcome, longer hospital stays, greater risk of complications and mortality. Currently in the UK, some sites have developed anaemia clinics or pathways that use intravenous iron to correct iron deficiency anaemia prior to surgery as their standard of care. Although intravenous iron has been observed to be effective in a variety of patient settings, there is insufficient evidence in its use in cardiac and vascular patients. The aim of this study is to observe the impact and effect of anaemia and its management in patients undergoing cardiac and vascular surgery. In addition, the UK Cardiac and Vascular Surgery Interventional Anaemia Response (CAVIAR) Study is also a feasibility study with the aim to establish anaemia management pathways in the preoperative setting to inform the design of future randomised controlled trials. METHODS AND ANALYSIS: The UK CAVIAR Study is a multicentre, stepped, observational study, in patients awaiting major cardiac or vascular surgery. We will be examining different haematological variables (especially hepcidin), functional capacity and patient outcome. Patients will be compared based on their anaemia status, whether they received intravenous iron in accordance to their hospital's preoperative pathway, and their disease group. The primary outcomes are the change in haemoglobin levels from baseline (before treatment) to before surgery; and the number of successful patients recruited and consented (feasibility). The secondary outcomes will include changes in biomarkers of iron deficiency, length of stay, quality of life and postoperative recovery. ETHICS AND DISSEMINATION: The study protocol was approved by the London-Westminster Research Ethics Committee (15/LO/1569, 27 November 2015). NHS approval was also obtained with each hospital trust. The findings of the study will be published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: Clinical Trials registry (NCT02637102) and the ISRCTN registry (ISRCTN55032357)

Project Antares: A low cost modular launch vehicle for the future

The single stage to orbit launch vehicle Antares is based upon the revolutionary concept of modularity, enabling the Antares to efficiently launch communications satellites, as well as heavy payloads, into Earth's orbit and beyond. The basic unit of the modular system, a single Antares vehicle, is aimed at launching approximately 10,000 kg into low Earth orbit (LEO). When coupled with a Centaur upper stage it is capable of placing 3500 kg into geostationary orbit. The Antares incorporates a reusable engine, the Dual Mixture Ratio Engine (DMRE), as its propulsive device. This enables Antares to compete and excel in the satellite launch market by dramatically reducing launch costs. Antares' projected launch costs are $1340 per kg to LEO which offers a tremendous savings over launch vehicles available today. Inherent in the design is the capability to attach several of these vehicles together to provide heavy lift capability. Any number of these vehicles, up to seven, can be attached depending on the payload and mission requirements. With a seven vehicle configuration Antares's modular concept provides a heavy lift capability of approximately 70,000 kg to LEO. This expandability allows for a wider range of payload options such as large Earth satellites, Space Station Freedom support, and interplanetary spacecraft, and also offers a significant cost savings over a mixed fleet based on different launch vehicles