Management of Postsurgical Hyperhidrosis With Direct Current and Tap Water

Background and Purpose. Excessive sweating, known as hyperhidrosis, involves the eccrine sweat glands of the axillae, soles, palms, and/or forehead. The use of iontophoresis to reduce or eliminate excessive sweating has been described since 1952. The purpose of this case report is to describe the use of tap water galvanism (TWG) using direct current (DC) with a patient who had postsurgical hyperhidrosis. Case Description. The patient was a 36-year-old male electrician with traumatic phalangeal amputation and postsurgical development of hyperhidrosis. Tap water galvanism was administered using a DC generator, 2 to 3 times per week for 10 treatments. The patient\u27s hands were individually submerged in 2 containers of tap water with the electrodes immersed directly into the containers. Each hand was treated with 30 minutes of TWG at 12 mA. Hyperhidrosis was measured by a 5-second imprint and subsequent tracing of the left hand placed on dry paper toweling. Outcomes. The patient\u27s hyperhidrosis decreased from the full left palmar pad, with a surface area of 10.3×12.0 cm, to a reduced area of wetness that covered a 2.2-×2.7-cm area. The patient returned to work as an electrician without needing absorbent gloves, which had prevented him from performing electrical work. Discussion. Following use of TWG, the patient\u27s palmar hyperhidrosis returned to normhidrosis

Engaging with students as partners in education-space design

Engaging with Students as Partners (SaP) in areas of curriculum design and pedagogic consultancy is relatively well established. Here we present a case study of two recent projects at Imperial College London, a research-intensive science, technology, engineering, mathematics, and medicine (STEMM) university, that have extended the SaP model to the design and delivery of modifications to education spaces. Using a research-informed approach and tested method ensured that the students remained active throughout the “twists and turns” of the project, rather than the more traditional snapshot student-consultation approach often taken early in the design process. Students experienced authentic partnership with staff, the space, and their department/institution more broadly whilst staff acknowledged that the quality of outputs significantly exceeded expectations at a fraction of the cost of engaging external design consultants. More broadly, projects such as these establish precedents for a more ambitious institutional approach to working with students as partners

Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis.

Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by recruitment of lymphocytes and neutrophils into the lamina propria. Based on genetic evidence that attenuation of the bridging integrator 1 (Bin1) gene can limit UC pathogenicity in animals, we have explored Bin1 targeting as a therapeutic option. Early feasibility studies in the dextran sodium sulfate mouse model of experimental colitis showed that administration of a cell-penetrating Bin1 monoclonal antibody (Bin1 mAb 99D) could prevent lesion formation in the colon mucosa in part by preventing rupture of lymphoid follicles. In vivo administration of Bin1 mAb altered tight junction protein expression and cecal barrier function. Strikingly, electrophysiology studies in organ cultures showed that Bin1 mAb could elevate resistance and lowe

Polymeric Bladder for Storing Liquid Oxygen

A proposed system for storing oxygen in liquid form and dispensing it in gaseous form is based on (1) initial subcooling of the liquid oxygen; (2) containing the liquid oxygen in a flexible vessel; (3) applying a gas spring to the flexible vessel to keep the oxygen compressed above the saturation pressure and, thus, in the liquid state; and (4) using heat leakage into the system for vaporizing the oxygen to be dispensed. In a typical prior system based on these principles, the flexible vessel is a metal bellows housed in a rigid tank, and the gas spring consists of pressurized helium in the tank volume surrounding the bellows. Unfortunately, the welds in the bellows corrugations are subject to fatigue, and, because bellows have large ullage, a correspondingly large fraction of the oxygen content cannot be expelled. In the proposed system, the flexible vessel would be a bladder made of a liquid- crystal polymer (LCP). (LCPs are strong and compatible with liquid oxygen.) In comparison with a metal bellows, a polymeric bladder would have less ullage and would weigh less. In experiments involving fatigue cycling at liquid-nitrogen temperatures, two LCPs were found to be suitable for this application

The On/Off Nature of Star-Planet Interactions

Evidence suggesting an observable magnetic interaction between a star and its hot Jupiter appears as a cyclic variation of stellar activity synchronized to the planet's orbit. In this study, we monitored the chromospheric activity of 7 stars with hot Jupiters using new high-resolution echelle spectra collected with ESPaDOnS over a few nights in 2005 and 2006 from the CFHT. We searched for variability in several stellar activity indicators (Ca II H, K, the Ca II infrared triplet, Halpha, and He I). HD 179949 has been observed almost every year since 2001. Synchronicity of the Ca II H & K emission with the orbit is clearly seen in four out of six epochs, while rotational modulation with P_rot=7 days is apparent in the other two seasons. We observe a similar phenomenon on upsilon And, which displays rotational modulation (P_rot=12 days) in September 2005, in 2002 and 2003 variations appear to correlate with the planet's orbital period. This on/off nature of star-planet interaction (SPI) in the two systems is likely a function of the changing stellar magnetic field structure throughout its activity cycle. Variability in the transiting system HD 189733 is likely associated with an active region rotating with the star, however, the flaring in excess of the rotational modulation may be associated with its hot Jupiter. As for HD 179949, the peak variability as measured by the mean absolute deviation for both HD 189733 and tau Boo leads the sub-planetary longitude by 70 degrees. The tentative correlation between this activity and the ratio of Mpsini to the planet's rotation period, a quantity proportional to the hot Jupiter's magnetic moment, first presented in Shkolnik et al. 2005 remains viable. This work furthers the characterization of SPI, improving its potential as a probe of extrasolar planetary magnetic fields.Comment: Accepted for publication in the Astrophysical Journa

The SDSS-2MASS-WISE Ten Dimensional Stellar Color Locus

We present the fiducial main sequence stellar locus traced by 10 photometric colors observed by SDSS, 2MASS, and WISE. Median colors are determined using 1,052,793 stars with r-band extinction less than 0.125. We use this locus to measure the dust extinction curve relative to the r-band, which is consistent with previous measurements in the SDSS and 2MASS bands. The WISE band extinction coefficients are larger than predicted by standard extinction models. Using 13 lines of sight, we find variations in the extinction curve in H, Ks, and WISE bandpasses. Relative extinction decreases towards Galactic anti-center, in agreement with prior studies. Relative extinction increases with Galactic latitude, in contrast to previous observations. This indicates a universal mid-IR extinction law does not exist due to variations in dust grain size and chemistry with Galactocentric position. A preliminary search for outliers due to warm circumstellar dust is also presented, using stars with high signal-to-noise in the W3-band. We find 199 such outliers, identified by excess emission in Ks-W3. Inspection of SDSS images for these outliers reveals a large number of contaminants due to nearby galaxies. Six sources appear to be genuine dust candidates, yielding a fraction of systems with infrared excess of 0.12$\pm$0.05%.Comment: 11 pages, 10 figures, MNRAS Accepted. Tables 1 and 2 available online: https://github.com/jradavenport/wise_locu