Northeast- or southwest-dipping subduction in the Cretaceous Caribbean gateway?

Most of the Caribbean plate, which currently lies between the American continents, represents a mantle plume-derived 8–20 km thick Cretaceous oceanic plateau that was formed in the Pacific region and moved eastwards. The northern islands of the Caribbean are largely made up of a dismembered island arc that was located along the western entrance to the inter-American region (termed the Great Arc of the Caribbean) in the mid-late Cretaceous. Importantly, the timing of Caribbean lithospheric movement into the inter-American region is controversial, with one hypothesis advocating that it happened in the Hauterivian-Albian (132.9–100.5 Ma), and a second hypothesis proposing the Turonian-Campanian (93.9–72.1 Ma). In order to investigate this problem, island arc rocks are studied on St. John, U.S. Virgin Islands, which are Barremian (127 Ma) to Santonian (83.6 Ma) in age. Immobile trace element and Ndsingle bondHf radiogenic isotope ratios demonstrate that the arc rocks are derived from the partial melting of an Atlantic MORB-like mantle source region that has been variably contaminated with slab-derived fluids composed of continental detritus and slow sediment clay components. We argue that the lack of a mantle plume geochemical signature in the rocks supports the idea that the movement of Caribbean lithosphere into the inter-American region occurred in the late Cretaceous (post-Santonian) due to a subduction polarity reversal caused by collision of the Caribbean oceanic plateau with the Great Arc of the Caribbean

Petrogenesis of plagiogranites in the Muslim Bagh Ophiolite, Pakistan: implications for the generation of Archaean continental crust

High-SiO2 rocks referred to as oceanic plagiogranites are common within the crustal sequences of ophiolites; however, their mode of petrogenesis is controversial with both late-stage fractional crystallization and partial melting models being proposed. Here, we present new whole-rock data from plagiogranitic dyke-like bodies and lenses from the lower and middle sections of the sheeted dyke complex of the Cretaceous Muslim Bagh Ophiolite, northwestern Pakistan. The plagiogranites have similar geochemical signatures that are inconsistent with them being the fractionation products of the mafic units of the Muslim Bagh Ophiolite. However, the plagiogranites all display very low TiO2 contents (<0.4 wt%), implying that they formed by partial melting of mafic rocks. Melt modelling of a crustal gabbro from the Muslim Bagh Ophiolite shows that the trace-element signature of the plagiogranites can be replicated by 5–10% melting of a crustal hornblende gabbro with amphibole as a residual phase, resulting in a concave-up middle rare Earth element pattern. Compositional similarities between the Muslim Bagh Ophiolite plagiogranites and Archaean TTG (trondhjemite–tonalite–granodiorite) has implications for the generation of juvenile Archaean continental crust. As the Muslim Bagh Ophiolite was derived in a supra-subduction zone, it is suggested that some Archaean TTG may have been derived from melting of mafic upper crust in early subduction-like settings. However, due to the small volume of Muslim Bagh Ophiolite plagiogranites, it is inferred that they can be instructive on the petrogenesis of some, but not all, Archaean TTG

Evolutionary History and Attenuation of Myxoma Virus on Two Continents

The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. We describe the genome-scale evolution of MYXV covering a range of virulence grades sampled over 49 years from the parallel Australian and European epidemics, including the high-virulence progenitor strains released in the early 1950s. MYXV evolved rapidly over the sampling period, exhibiting one of the highest nucleotide substitution rates ever reported for a double-stranded DNA virus, and indicative of a relatively high mutation rate and/or a continually changing selective environment. Our comparative sequence data reveal that changes in virulence involved multiple genes, likely losses of gene function due to insertion-deletion events, and no mutations common to specific virulence grades. Hence, despite the similarity in selection pressures there are multiple genetic routes to attain either highly virulent or attenuated phenotypes in MYXV, resulting in convergence for phenotype but not genotype. © 2012 Kerr et al

A best online algorithm for scheduling on two parallel batch machines

AbstractWe consider the online scheduling on two parallel batch machines with infinite batch size to minimize makespan, where jobs arrive over time. That is, all information of a job is not available until it is released. For this online scheduling problem, Nong et al. [Q.Q. Nong, T.C.E. Cheng, C.T. Ng, An improved online algorithm for scheduling on two unrestrictive parallel batch processing machines, Operations Research Letters, 36 (2008) 584–588] have provided an online algorithm with competitive ratio no greater than 2. We show that this bound is tight for the problem. Furthermore we give a new best possible online algorithm with a tighter structure

Evidence for subaerial development of the Caribbean oceanic plateau in the Late Cretaceous and palaeo-environmental implications

The formation of oceanic plateaus in the Pacific in the Mesozoic has been proposed to create major environmental impacts, including global anoxic events OAE-1 in the Aptian (ca. 120 Ma) and OAE-2 in the Cenomanian–Turonian (ca. 90 Ma). However, our understanding of the formation of these large volcanic systems and their environmental effects are strongly limited by difficulties in accessing them and characterising their volcanic evolution. In particular, it remains significant to determine whether Pacific oceanic plateaus experience a phase of subaerial volcanic activity as this has critical implications in terms of their environmental impacts. Herein we provide the first unequivocal evidence for an emergent volcanic phase of the Caribbean oceanic plateau in the Late Cretaceous. This subaerial phase is evidenced by accreted oceanic sequences in Colombia that include fallout tuffs with accretionary lapilli and lahar deposits. This facies assemblage, recognised for the first time in an oceanic plateau, reflects phreatomagmatic eruptions coeval with subaerial erosion on an oceanic island. This result, combined with previous evidence of subaerial development of the Ontong Java Plateau and Shatsky Rise, suggests that syn-volcanic emergence of oceanic plateaus was common in the Pacific during the Mesozoic. Although temporal and spatial scales of these emergences remain poorly constrained it confirms that emergence of the Caribbean plateau in the Late Cretaceous (ca. 90 Ma) could have actively contributed to atmospheric changes and the establishment of OAE-2. Significantly, emergence of the Caribbean plateau occurred synchronously to the beginning of its tectonic displacement between the Americas. We propose that this unusual volcanic and tectonic evolution led to drastic reduction of the flow of Pacific oxygenated bottom waters into the early Atlantic basin, leading to a series of regional anoxic events previously documented between the Coniacian and Santonian (OAE-3, ca. 89 to 84 Ma). In addition, emergence of the Caribbean Plateau in the early inter-American seaway could have facilitated migration of terrestrial organisms between the Americas in the Late Cretaceous. The formation of the Caribbean plateau had therefore a large range of possible environmental effects, from atmospheric to palaeo-oceanographic and biotic impacts

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer

Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal cancer. Methods All serious adverse events that were cardiovascular thrombotic events were reviewed in 2434 patients with stage II or III colorectal cancer participating in a randomized, placebo-controlled trial of rofecoxib, 25 mg daily, started after potentially curative tumor resection and chemotherapy or radiotherapy as indicated. The trial was terminated prematurely owing to worldwide withdrawal of rofecoxib. To examine possible persistent risks, we examined cardiovascular thrombotic events reported up to 24 months after the trial was closed. Results The median duration of active treatment was 7.4 months. The 1167 patients receiving rofecoxib and the 1160 patients receiving placebo were well matched, with a median follow-up period of 33.0 months (interquartile range, 27.6 to 40.1) and 33.4 months (27.7 to 40.4), respectively. Of the 23 confirmed cardiovascular thrombotic events, 16 occurred in the rofecoxib group during or within 14 days after the treatment period, with an estimated relative risk of 2.66 (from the Cox proportional-hazards model; 95% confidence interval [CI], 1.03 to 6.86; P = 0.04). Analysis of the Antiplatelet Trialists’ Collaboration end point (the combined incidence of death from cardiovascular, hemorrhagic, and unknown causes; of nonfatal myocardial infarction; and of nonfatal ischemic and hemorrhagic stroke) gave an unadjusted relative risk of 1.60 (95% CI, 0.57 to 4.51; P = 0.37). Fourteen more cardiovascular thrombotic events, six in the rofecoxib group, were reported within the 2 years after trial closure, with an overall unadjusted relative risk of 1.50 (95% CI, 0.76 to 2.94; P = 0.24). Four patients in the rofecoxib group and two in the placebo group died from thrombotic causes during or within 14 days after the treatment period, and during the follow-up period, one patient in the rofecoxib group and five patients in the placebo group died from cardiovascular causes. Conclusions Rofecoxib therapy was associated with an increased frequency of adverse cardiovascular events among patients with a median study treatment of 7.4 months’ duration. (Current Controlled Trials number, ISRCTN98278138.

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility. Here we report a biomaterial-based scaffold that mimics features of T cell lymphopoiesis in the bone marrow. The bone marrow cryogel (BMC) releases bone morphogenetic protein-2 to recruit stromal cells and presents the Notch ligand Delta-like ligand-4 to facilitate T cell lineage specification of mouse and human hematopoietic progenitor cells. BMCs subcutaneously injected in mice at the time of HSCT enhanced T cell progenitor seeding of the thymus, T cell neogenesis and diversification of the T cell receptor repertoire. Peripheral T cell reconstitution increased ~6-fold in mouse HSCT and ~2-fold in human xenogeneic HSCT. Furthermore, BMCs promoted donor CD4+ regulatory T cell generation and improved survival after allogeneic HSCT. In comparison to adoptive transfer of T cell progenitors, BMCs increased donor chimerism, T cell generation and antigen-specific T cell responses to vaccination. BMCs may provide an off-the-shelf approach for enhancing T cell regeneration and mitigating graft-versus-host disease in HSCT

TEAMwork: Testing Emotional Attunement and Mutuality During Parent-Adolescent fMRI.

The parent-child relationship and family context influence the development of emotion regulation (ER) brain circuitry and related skills in children and adolescents. Although both parents' and children's ER neurocircuitry simultaneously affect how they interact with one another, neuroimaging studies of parent-child relationships typically include only one member of the dyad in brain imaging procedures. The current study examined brain activation related to parenting and ER in parent-adolescent dyads during concurrent fMRI scanning with a novel task - the Testing Emotional Attunement and Mutuality (TEAM) task. The TEAM task includes feedback trials indicating the other dyad member made an error, resulting in a monetary loss for both participants. Results indicate that positive parenting practices as reported by the adolescent were positively correlated with parents' hemodynamic activation of the ventromedial prefrontal cortex, a region related to empathy, during these error trials. Additionally, during feedback conditions both parents and adolescents exhibited fMRI activation in ER-related regions, including the dorsolateral prefrontal cortex, anterior insula, fusiform gyrus, thalamus, caudate, precuneus, and superior parietal lobule. Adolescents had higher left amygdala activation than parents during the feedback condition. These findings demonstrate the utility of dyadic fMRI scanning for investigating relational processes, particularly in the parent-child relationship

Chronology and geochemistry of the Caribbean Large Igneous Province in Jamaica

Jamaica has a complex geological history with rocks belonging to the Cretaceous Caribbean Large Igneous Province (CLIP) in the east and Cretaceous oceanic island arc rocks in the centre and west. We present a new geochemical dataset for the CLIP and correlate this dataset and previous datasets using radiolarians and planktic foraminifers to the geological timescale. The palaeontological dating indicates that two phases of plateau activity – ‘main’ phase in the late Turonian-mid Coniacian (c. 92-87 Ma) and an ‘extended’ phase in the Coniacian to mid Campanian (c. 88-75 Ma). These phases are also seen in the Beata Ridge and on the Lower Nicaragua Rise. The geochemistry indicates that both phases are typical large igneous province plateau basalts. The ‘main’ phase has slightly more depleted light rare earth elements than the extended phase, indicating mantle source heterogeneity, and a (Sm/Yb)n >1 indicates a deeper average depth of melting for the ‘main’ phase. The association of the basalts with sediments containing specific microfossil assemblages clearly demonstrates the existence of these two magmatic phases in Jamaica