A follow-up empirical analysis of Scottish construction clients' interaction with mediation

Although across many jurisdictions, mediation’s origins (in the modern sense at least1) often lay in the dispute areas of family and community matters, in recent years the process has begun to take root in the arena of construction disputes (for an international review of developments see Brooker and Wilkinson 2010). In contrast to traditional means of resolving disputes, it is contended that mediation may be a quicker, cheaper, less adversarial and more harmonious form of dispute resolution than traditional methods

Construction clients and mediation: a follow-up study of attitudes and experience

Construction disputes by their very nature are often complex, sometimes multi-party disputes, many of which are not suited to either adjudication or traditional forms of dispute resolution (these being potentially slow, expensive and divisive). The sheer complexity of construction disputes often leading to expensive, time-consuming and stressful paths being trodden through the traditional resolution terrain, creates a compelling case for the introduction of alternative approaches within this adversarial industry. The construction industry has become increasingly aware of the substantial legal costs it burdens itself with as a consequence of its high incidence of disputes. Moreover, this expenditure, which globally represents a substantial sum each year, is by no means reflective of the hidden costs of disputes, such as the damage to reputations and commercial relationships; cost of time spent by executive personnel; and cost of lost business opportunities. Over recent years, the Scottish Government and key players in Scottish commerce have emerged as advocates of mediation as a first choice method of settling disputes. The value of mediation has also been widely acknowledged worldwide, as evidenced by the number of jurisdictions in which the courts enforce obligations on parties to negotiate and adopt mediation to settle construction disputes. In most contexts, voluntary uptake of the process is low, however, and research into prospective client perceptions is particularly valuable. The principal aim then of this study was to explore construction participants’ [construction clients hereafter] awareness, attitudes and experiences relative to mediation, drawing upon quantitative and qualitative analyses of small and medium-sized contracting firms in Scotland. This was reflected in the main objectives of this research which were to evaluate the effectiveness of prevailing construction dispute resolution methods in Scotland; establish baseline information about the current extent of construction mediation activity in Scotland, determine the willingness of Scottish construction clients to shift away from traditional approaches to dispute resolution to mediation; and if they are, to ascertain the drivers towards the adoption of mediatory techniques, and if not the barriers to change

PAMELA: An Open-Source Software Package for Calculating Nonlocal Exact Exchange Effects on Electron Gases in Core-Shell Nanowires

We present a new pseudospectral approach for incorporating many-body, nonlocal exact exchange interactions to understand the formation of electron gases in core-shell nanowires. Our approach is efficiently implemented in the open-source software package PAMELA (Pseudospectral Analysis Method with Exchange & Local Approximations) that can calculate electronic energies, densities, wavefunctions, and band-bending diagrams within a self-consistent Schrodinger-Poisson formalism. The implementation of both local and nonlocal electronic effects using pseudospectral methods is key to PAMELA's efficiency, resulting in significantly reduced computational effort compared to finite-element methods. In contrast to the new nonlocal exchange formalism implemented in this work, we find that the simple, conventional Schrodinger-Poisson approaches commonly used in the literature (1) considerably overestimate the number of occupied electron levels, (2) overdelocalize electrons in nanowires, and (3) significantly underestimate the relative energy separation between electronic subbands. In addition, we perform several calculations in the high-doping regime that show a critical tunneling depth exists in these nanosystems where tunneling from the core-shell interface to the nanowire edge becomes the dominant mechanism of electron gas formation. Finally, in order to present a general-purpose set of tools that both experimentalists and theorists can easily use to predict electron gas formation in core-shell nanowires, we document and provide our efficient and user-friendly PAMELA source code that is freely available at http://alum.mit.edu/www/usagiComment: Accepted by AIP Advance

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors.

BackgroundThe tumor-specific microregional effects of the anticancer agent RRx-001, a novel epigenetic-based radio/chemosensitizer with nitrogen oxide-donating properties in phase II clinical trials, were investigated with whole tissue section quantitative immunohistological staining in mouse SCCVII and human U87 tumors.ResultsSCCVII tumors exhibited regions of intermittent perfusion exemplified by co-localization of vessels with the hypoxia marker pimonidazole commonly occurring throughout the tissue. A moderate increase in perfusion (21 to 28 %) was observed after a bolus dose of the perivascular stain DiOC7(3), however, with the absence of an increase in tissue oxygenation. U87 tumors showed an absence of blood flow over large areas of treated tumors after dosing with RRx-001. However, these areas did not become necrotic and returned to near normal levels after 12 h. No significant change in tumor hypoxia was seen at 90 min or 12 h. For both tumor types, RRx-001 treatment resulted in the loss of perfusion in the large regions of the tumor; however, at the 12-h time point, both tumor types showed an increase in vessel perfusion but no significant decrease in hypoxia.ConclusionsThese data suggest a redistribution of blood flow within the tumor for both tumor types akin to vascular normalization. Differences between the tumors were related to tumor architecture and distribution of alpha-smooth muscle actin (α-SMA). RRx-001 shows promise for short-term blood flow redistribution in tumors with a pericyte- and α-SMA-rich vasculature. Expression of α-SMA in tumor vasculature could therefore be useful for predicting tumor response to RRx-001

Simulating Metal Mixing of Both Common and Rare Enrichment Sources in a Low-mass Dwarf Galaxy

One-zone models constructed to match observed stellar abundance patterns have been used extensively to constrain the sites of nucleosynthesis with sophisticated libraries of stellar evolution and stellar yields. The metal mixing included in these models is usually highly simplified, although it is likely to be a significant driver of abundance evolution. In this work we use high-resolution hydrodynamics simulations to investigate how metals from individual enrichment events with varying source energies E_(ej) mix throughout the multiphase interstellar medium (ISM) of a low-mass (M_(gas) = 2 × 10⁶ M_⊙), low-metallicity, isolated dwarf galaxy. These events correspond to the characteristic energies of both common and exotic astrophysical sites of nucleosynthesis, including asymptotic giant branch winds (E_(ej) ~ 10⁴⁶ erg), neutron star–neutron star mergers (E_(ej) ~ 10⁴⁹ erg), supernovae (E_(ej) ~ 10⁵¹ erg), and hypernovae (E_(ej) ~ 10⁵² erg). We find the mixing timescales for individual enrichment sources in our dwarf galaxy to be long (100 Myr–1 Gyr), with a clear trend of increasing homogeneity for the more energetic events. Given these timescales, we conclude that the spatial distribution and frequency of events are important drivers of abundance homogeneity on large scales; rare, low-E_(ej) events should be characterized by particularly broad abundance distributions. The source energy E_(ej) also correlates with the fraction of metals ejected in galactic winds, ranging anywhere from 60% at the lowest energy to 95% for hypernovae. We conclude by examining how the radial position, local ISM density, and global star formation rate influence these results

Bond Patterns in the Ground States of Quasi-One Dimensional 1/4-Filled Organic Superconductors

Organic conductors are of considerable interest to the condensed matter community. In contrast to conventional metal conductors, these organic materials allow for large variability in their construction giving both quasi-one and two dimensional behavior. Organic superconductors also give useful insight into the properties of general superconductivity as well as insight into the properties of strongly correlated electronic materials. These materials exhibit interesting phenomena like spin-Peierls, antiferromagnetic, and superconducting phases. The aim of this thesis is not only to inform the reader of various studies into organic superconductors but also to advance research into these materials through massively parallel numerical methods. This thesis will cover two studies: a quantum Monte Carlo study on an infinite one-dimensional chain and an exact diagonalization study on a 16-site two-dimensional lattice. These studies will be used to better understand the charge and bond behavior of quasi-one dimensional 1/4illed organic superconductors