L^p estimates for Feynman-Kac propagators with time-dependent reference measures

We introduce a class of time-inhomogeneous transition operators of Feynman-Kac type that can be considered as a generalization of symmetric Markov semigroups to the case of a time-dependent reference measure. Applying weighted Poincar\'e and logarithmic Sobolev inequalities, we derive L^p-L^p and L^p-L^q estimates for the transition operators. Since the operators are not Markovian, the estimates depend crucially on the value of p. Our studies are motivated by applications to sequential Markov Chain Monte Carlo methods.Comment: 20 pages, minor error corrected, examples and references adde

Test and Modelling of Commercial V2G CHAdeMO Chargers to Assess the Suitability for Grid Services

Aggregation and control of electric vehicles (EVs) via vehicle-to-grid (V2G) technologies is seen as a valid option for providing ancillary power system services. This work presents results from V2G-ready equipment tests and modelling. The technical capabilities of an EV connected to a commercial V2G charger are investigated when controlled either locally or remotely. The charger is characterized in terms of efficiency characteristics, activation time, response granularity, ramping-up/down time, accuracy and precision. Test results show the performance for different operating conditions, highlighting the importance of a good calibration and knowledge of the employed hardware when providing standard-compliant grid regulation services via V2G technology. Ultimately, a set of simulations demonstrates that the designed EV charger model replicates accurately the operating conditions of the real hardware

Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1-mediated H3K9me3 and DNA methylation. However, the protein network which regulates the deposition of these chromatin modifications is still incompletely understood. Here, we perform a genome-wide single guide RNA (sgRNA) screen for genes involved in ERV silencing and identify the GHKL ATPase protein Morc3 as a top-scoring hit. Morc3 knock-out (ko) cells display de-repression, reduced H3K9me3, and increased chromatin accessibility of distinct ERV families. We find that the Morc3 ATPase cycle and Morc3 SUMOylation are important for ERV chromatin regulation. Proteomic analyses reveal that Morc3 mutant proteins fail to interact with the histone H3.3 chaperone Daxx. This interaction depends on Morc3 SUMOylation and Daxx SUMO binding. Notably, in Morc3 ko cells, we observe strongly reduced histone H3.3 on Morc3 binding sites. Thus, our data demonstrate Morc3 as a critical regulator of Daxx-mediated histone H3.3 incorporation to ERV regions

Working Document: Towards a vision for research, technology and innovation cooperation between Russia and the EU, its Member States and Associated States

This Working Document outlines development perspectives for cooperation in research, technology and innovation (RTI) between the EU, its Member States (MS), countries associated to the EU’s FP7 (AC), and Russia. The Working Document has been prepared in the framework of the ERA.Net RUS project and is based on a comprehensive foresight exercise implemented over the years 2010-2013 and on analysis of ongoing RTI cooperation. In-depth discussions among the ERA.Net RUS and ERA.Net RUS Plus consortiums and Funding Parties, and in the frame of expert workshops with policy makers and analysts provided essential input. Furthermore, results of other related projects (such as BILAT-RUS, BILAT-RUS Advanced, ACCESSRU, etc.) have been studied. The paper proposes a vision on enhancing the cooperation between EU MS/AC and Russia overall, as well as a specific follow-up vision for the ERA.Net RUS and ERA.Net RUS Plus projects.JRC.J.2-Knowledge for Growt