Scent whisper

Scent Whisper is a jewellery set integrated with wireless sensor networks that offer social and therapeutic value in a desirable context. The jewellery incorporates sensors and microfluidics to initiate fragrance delivery, depending on the sensor response. A wireless humidity sensor is used to trigger scent output in these proof-of-concept devices. Future devices will use sensors to detect stress physiologically and release benefit chemicals in controlled ways responding to personal needs. About this conference: MEMS technology (micro-electro-mechanical-systems) is advancing rapidly, and over the last five years has allowed the construction of many integrated systems, including (for example) novel micro and nano structured materials, sensors based on movable mechanical components and self powered autonomous devices. Many involve nanotechnology. These components are allowing systems that were once confined to the laboratory to find new applications with a strong commercial potential. UK activity is now rapidly increasing, after a relatively slow start compared to the rest of the advanced industrial nations. The aim of this event is to bring together UK expertise in MEMS, to introduce the advantage of MEMS process technology and to highlight developments. The topics will be relevant to companies engaged in sensor manufacture and process control, equipment manufacturers for the semiconductor industry and academics engaged in MEMS, nanotechnology and sensor researc

What Can Chips Technology Offer for Next Century's Chemistry and Life Sciences?

Microfabrication gives access to surfaces of a few micron square, and the volumes of picoliter and femtoliter size. Integration of combinatorial synthesis, analysis speed, and small-volume handling are the main advantages. Examples of experimental results in drug discovery, analytical chemistry, and microbiology exhibit the potential of the chip-microstructure approach

Picoliter Cell Volume Potentiometric Detector for Open-Tubular Column LC

A detector for open-tubular column liquid chromatography based on an ion-selective microelectrode cell assembly is described. The microelectrode with tip diameter of approximately 1 μm is directly inserted into the downstream column end. Estimated detector cell volumes are about 10−14 l (25-μm i.d. column). Experimental evidence is presented that proves the cell volume to be smaller than 5 × 10−10 l. The detection system should be adequate for open-tubular columns with an inner diameter ≥ 5 μ

An Experimental and Numerical Investigation of Drag Reduction Through Biomimetic Modelling

This paper characterises flow around a circular cylinder and investigates the potential of a non-smooth surface to reduce air resistance in a Reynolds number range between Red = 8.09 104 and Red = 2.02 105. The two- and three-dimensional numerical simulations were performed using a steady-state solution and the Reynolds-averaged Navier-Stokes (RANS) approaches. Three different mesh designs and four turbulence models with various treatments were assessed and compared against experimental data. A total of 26 uneven preparations in the two-dimensional analysis and two riblet structures in the three-dimensional analysis were designed to investigate the effect of drag reduction. The results reported hold the potential of uneven structures to reduce the air resistance in the case of a circular cylinder. This research further demonstrates that engineering applications can benefit from mimicking nature's details and functions

Tungsten-siliconnitride medium for mega- to gigayear data storage

Throughout the ages humanity has stored data in order to preserve important information for generations to come. As the years have progressed the amount of data that can be stored efficiently has increased tremendously, the lifespan of this type of data storage however is severely limited. Within this paper we investigate the possibility to store data by encapsulating W in a SiN matrix.We show that using accelerated thermal aging the possible lifespan of this medium can be investigated and expected to reach well into the millions of years, preserving data for thousands of future generations. The first steps into fabrication of such a medium are discussed

Psychiatric Comorbidity and Stress in Medical Students Using Neuroenhancers

Background: Pharmacological neuroenhancement (PN) is a common healthcare problem at least among students. PN seems to be associated with stressful situations. There is a lack of data about personal characteristics, comorbidities, and coping strategies regarding stress and factors of resilience in students and medical staff. Methods: A web-based survey about the non-medical use of PN drugs with a focus on neuroenhancement was developed and distributed among medical students throughout Germany; the questionnaire was open in April and May of 2020. The survey contained questions about the use of well-known PN drugs, frequency, special purposes, reasons for the use, psychiatric disorders, use of psychotropic drugs apart from PN purposes, and factors of resilience using the brief resilience scale. Results: Data of 1,159 students of medicine were analyzed. The most frequently used substances for PN were coffee (78.8% lifetime prevalence rate), energy drinks (45.7%), caffeine tablets (24.3%), methylphenidate (5.2%), illicit amphetamines (2.0%), and cocaine (1.7%). 98.4% suspected that PN drug use could lead to addiction. PN drug use specifically for PN was significantly associated with the use of (a) any psychotropic drug (other than neuroenhancers), (b) any psychiatric disorder, and (c) higher values of feeling pressure to perform in professional/students' life and in private life as well as (d) the subjective feeling of pressure to perform to be burdening and (e) harmful to one's own health. PN drug use in general was significantly associated with being less resilient. The use of illicit PN drugs, over the counter drugs and prescription drugs was associated with being less resilient. Conclusion: This study indicates that PN with legal and illegal drugs is a widespread phenomenon among German medical students. Users seem to be more often burdened by psychiatric disorders, especially addictive disorders, the perception of stress, pressure to perform and low levels of resilience. These aspects should be considered in further investigation of PN drug use

Efficacy and Safety of Approved First-Line Tyrosine Kinase Inhibitor Treatments in Metastatic Renal Cell Carcinoma: A Network Meta-Analysis

Introduction This network meta-analysis aims to deliver an up-to-date, comprehensive efficacy and toxicity comparison of the approved first-line tyrosine kinase inhibitors (TKIs) for metastatic renal cell carcinoma (mRCC) in order to provide support for evidence-based treatment decisions. Previous NMAs of first-line mRCC treatments either predate the approval of all the first-line TKIs currently available or do not include evaluation of safety data for all treatments. Methods We performed a systematic literature review and network meta-analysis of phase II/III randomised controlled trials (RCTs) assessing approved first-line TKI therapies for mRCC. A random effects model with a frequentist approach was computed for progression-free survival (PFS) data and for the proportion of patients experiencing a maximum of grade 3 or 4 adverse events (AEs). Results The network meta-analysis of PFS demonstrated no significant differences between cabozantinib and either sunitinib (50 mg 4/2), pazopanib or tivozanib. The network meta-analysis indicated that in terms of grade 3 and 4 AEs, tivozanib had the most favourable safety profile and was associated with significantly less risk of toxicity than the other TKIs. Conclusion These network meta-analysis data demonstrate that cabozantinib, sunitinib, pazopanib and tivozanib do not significantly differ in their efficacy, but tivozanib is associated with a more favourable safety profile in terms of grade 3 or 4 toxicities. Consequently, the relative toxicity of these first-line TKIs may play a more significant role than efficacy comparisons in treatment decisions and in planning future RCTs