PALPAS - PAsswordLess PAssword Synchronization

Tools that synchronize passwords over several user devices typically store the encrypted passwords in a central online database. For encryption, a low-entropy, password-based key is used. Such a database may be subject to unauthorized access which can lead to the disclosure of all passwords by an offline brute-force attack. In this paper, we present PALPAS, a secure and user-friendly tool that synchronizes passwords between user devices without storing information about them centrally. The idea of PALPAS is to generate a password from a high entropy secret shared by all devices and a random salt value for each service. Only the salt values are stored on a server but not the secret. The salt enables the user devices to generate the same password but is statistically independent of the password. In order for PALPAS to generate passwords according to different password policies, we also present a mechanism that automatically retrieves and processes the password requirements of services. PALPAS users need to only memorize a single password and the setup of PALPAS on a further device demands only a one-time transfer of few static data.Comment: An extended abstract of this work appears in the proceedings of ARES 201

The evolution of innovation networks : the case of a German automotive network

In this paper we outline a conceptual framework for depicting network development patterns of interfirm innovation networks and for analyzing the dynamic evolution of an R&D network in the German automotive industry. We test the drivers of evolutionary change processes of a network which is based on subsidised R&D projects in the 10 year period between 1998 and 2007. For this purpose a stochastic actor-based model is applied to estimate the impact of various drivers of network change. We test hypotheses in the innovation and evolutionary economics framework and show that structural positions of firms as well as actor covariates and dyadic covariates are influential determinants of network evolution

Application of Stem Cells in Orthopedics

Stem cell research plays an important role in orthopedic regenerative medicine today. Current literature provides us with promising results from animal research in the fields of bone, tendon, and cartilage repair. While early clinical results are already published for bone and cartilage repair, the data about tendon repair is limited to animal studies. The success of these techniques remains inconsistent in all three mentioned areas. This may be due to different application techniques varying from simple mesenchymal stem cell injection up to complex tissue engineering. However, the ideal carrier for the stem cells still remains controversial. This paper aims to provide a better understanding of current basic research and clinical data concerning stem cell research in bone, tendon, and cartilage repair. Furthermore, a focus is set on different stem cell application techniques in tendon reconstruction, cartilage repair, and filling of bone defects

Drought alters timing, quantity, and quality of wood formation in Scots pine

Drought has been frequently discussed as a trigger for forest decline. Today, large-scale Scots pine decline is observed in many dry inner-Alpine valleys, with drought discussed as the main causative factor. This study aimed to analyse the impact of drought on wood formation and wood structure. To study tree growth under contrasting water supply, an irrigation experiment was installed in a mature Scots pine (Pinus sylvestris L.) forest at a xeric site in a dry inner-Alpine valley. Inter- and intra-annual radial increments as well as intra-annual variations in wood structure of pine trees were studied. It was found that non-irrigated trees had a noticeably shorter period of wood formation and showed a significantly lower increment. The water conduction cells were significantly enlarged and had significantly thinner cell walls compared with irrigated trees. It is concluded that pine trees under drought stress build a more effective water-conducting system (larger tracheids) at the cost of a probably higher vulnerability to cavitation (larger tracheids with thinner cell walls) but without losing their capability to recover. The significant shortening of the growth period in control trees indicated that the period where wood formation actually takes place can be much shorter under drought than the ‘potential' period, meaning the phenological growth perio

Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline

Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences APOE ɛ4's association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression. Generally, ɛ4 carriers displayed a higher Aβ load. Moreover, Aβ normal (Aβ-) ɛ4 carriers demonstrated higher accumulation. Next, we categorized accumulation phases as "decrease", "stable", or "increase" based on trajectory shapes. After excluding the Aβ-/decrease participants from the initial regression, the difference in accumulation attributable to genotype among Aβ- individuals was no longer significant. Further analysis revealed that in increase phases, Aβ accumulation was higher among noncarriers, indicating a genotype-related timeline shift. Finally, cognitive decline was analyzed across phases and was already evident in the Aβ-/increase phase. Our results encourage early interventions for ɛ4 carriers and imply that monitoring accumulating Aβ- individuals might help identify those at risk for cognitive decline

A Peer-to-Peer Approach to Content-Based Publish/Subscribe

Publish/subscribe systems are successfully used to decouple distributed applications. However, their e#ciency is closely tied to the topology of the underlying network, the design of which has been neglected. Peer-to-peer network topologies can o#er inherently bounded delivery depth, load sharing, and self-organisation. In this paper, we present a contentbased publish/subscribe system routed over a peer-to-peer topology graph. The implications of combining these approaches are explored and a particular implementation using elements from Rebeca and Chord is proven correct

Kohlenstoffspeicherung und Treibhausgasflüsse in Böden unter biologischer und konventioneller Bewirtschaftung – Ergebnisse aus zwei globalen Meta-Analysen

Explorative literature searches followed by meta-analyses were conducted to identify differences in soil organic carbon (SOC) and soil-derived greenhouse gas emissions between organic and non-organic farming systems. Within a total of 74 studies we found significantly higher SOC concentrations, SOC stocks and C sequestration rates in organically managed soils compared to those under non-organic management. Meta-analysis of soil-derived GHG flux data from 19 studies revealed lower N2O emissions and higher CH4 uptake rates in soils under organic management when related to acreage. Due to lower yields in organic farming systems higher GHG emissions from these systems were obtained when the data was related to unit crop yield. The poor availability of farming system comparisons from developing countries, at present, renders the transfer of the obtained results to these extremely vulnerable environments difficult. However, the presented approach is open to regular updates once relevant data from these regions are published

Forward Secure Signatures on Smart Cards

We introduce the forward secure signature scheme XMSS$^{+}$ and present an implementation for smart cards. It is based on the hash-based signature scheme XMSS. In contrast to the only previous implementation of a hash-based signature scheme on smart cards by Rohde et al., we solve the problem of on-card key generation. Compared to XMSS, we reduce the key generation time from $\mathcal{O}(n)$ to $\mathcal{O}(\sqrt{n})$, where $n$ is the number of signatures that can be created with one key pair. To the best of our knowledge this is the first implementation of a forward secure signature scheme and the first full implementation of a hash-based signature scheme on smart cards. The resulting runtimes are comparable to those of RSA and ECDSA on the same device. This shows the practicality of forward secure signature schemes, even on constrained devices

Optimal Parameters for XMSS^MT

We introduce Multi Tree XMSS (XMSS^MT), a hash-based signature scheme that can be used to sign a virtually unlimited number of messages. It is provably forward and hence EU-CMA secure in the standard model and improves key and signature generation times compared to previous schemes. XMSS^MT has --- like all practical hash-based signature schemes --- a lot of parameters that control different trade-offs between security, runtimes and sizes. Using linear optimization, we show how to select provably optimal parameter sets for different use cases

Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease

Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evidence suggests that brain maturation can be delayed and pre- and postoperative brain injury may occur, and there is limited information on the long-term effect of congenital heart disease on brain development and function in adolescent patients. At a mean age of 13.8 years, 39 adolescent survivors of childhood cardiopulmonary bypass surgery with no structural brain lesions evident through conventional cerebral magnetic resonance imaging and 32 healthy control subjects underwent extensive neurodevelopmental assessment and cerebral magnetic resonance imaging. Cerebral scans were analysed quantitatively using surface-based and voxel-based morphometry. Compared with control subjects, patients had lower total brain (P = 0.003), white matter (P = 0.004) and cortical grey matter (P = 0.005) volumes, whereas cerebrospinal fluid volumes were not different. Regional brain volume reduction ranged from 5.3% (cortical grey matter) to 11% (corpus callosum). Adolescents with cyanotic heart disease showed more brain volume loss than those with acyanotic heart disease, particularly in the white matter, thalami, hippocampi and corpus callosum (all P-values < 0.05). Brain volume reduction correlated significantly with cognitive, motor and executive functions (grey matter: P < 0.05, white matter: P < 0.01). Our findings suggest that there are long-lasting cerebral changes in adolescent survivors of cardiopulmonary bypass surgery for congenital heart disease and that these changes are associated with functional outcom