W + Jet Production at CDF

The cross section for the inclusive production of W bosons in association with jets in ppbar collisions at sqrt(s)=1.96 TeV using the Collider Detector at Fermilab (CDF II) is presented. The measurement is based on an integrated luminosity of 320pb^-1, and includes events with up to 4 or more jets. In each jet multiplicity sample the differential and cumulative cross sections with respect to the transverse energy of the i^th-jet are measured. For W+>=2 jets the differential cross section with respect to the 2-leading jets invariant mass m_j1j2 and angular separation Delta R_j1j2 is also reported. The data are compared to predictions from Monte Carlo simulations.Comment: 4 pages, FERMILAB-CONF-06-377-E, to appear in the proceedings of the 14th International Workshop on Deep Inelastic Scattering (DIS2006

Latest Jet Results from Tevatron

This contribution reports preliminary jet results in ppbar collisions at sqrt(s)=1.96 TeV from the CDF and D0 experiments. The jet inclusive cross section, measured using both the Midpoint and the K_T jet clustering algorithm, is compared to next-to-leading order QCD prediction in different rapidity regions. The b-jet inclusive cross section measured exploiting the long lifetime and large mass of B hadrons is presented and compared to QCD prediction. A complementary measurement, using the large branching fraction of B hadrons into muons, is also described. The measurement of two-particle momentum correlation in jets is presented and compared to predictions.Comment: 4 pages, Moriond QCD 2006 conference proceedin

Measurement of the W + Jet Cross Section at CDF

A measurement of W->e nu + n-jet cross sections in ppbar collisions at sqrt(s)=1.96 TeV using the Collider Detector at Fermilab in Run II is presented. The measurement is based on an integrated luminosity of 320 pb-1, and includes events with jet multiplicity from >= 1 to >= 4. In each jet multiplicity sample the differential and cumulative cross sections with respect to the transverse energy of the n^(th)-leading jet are measured. For W+>=2 jets the differential cross section with respect to the 2-leading jets invariant mass m_(j_(1)j_(2)) and angular separation Delta R_(j_(1)j_(2)) is also reported. The data are compared to predictions from Monte Carlo simulations.Comment: 3 pages, Presented at the XXXVI international Symposium on Multiparticle Dynamics (ISMD 2006), Rio De Janeiro, Brazil, 2-8 Sept 200

In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). In this work, we designed novel IDE-loaded NLC containing tocopheryl acetate (VitE) as a liquid component to obtain a synergic effect between IDE and VitE. The resulting NLC showed small particle sizes (24-42 nm), low polydispersity indices (<0.300), good stability, and were assessed for their in vitro antioxidant activity and in vivo topical effects. IDE-loaded SLN and NLC showed a high antioxidant activity in in vitro assays (DPPH and reducing power method) and provided a similar and significant protection from oxidative stress of fibroblast cells, HS-68, exposed to UV light. After a two-week topical treatment of human volunteers with gels containing IDE-loaded SLN or NLC, a similar increase in skin hydration was observed, while IDE NLC reduced skin pigmentation to a greater extent than IDE SLN. These results suggest that co-loading IDE and VitE into NLC could be a promising strategy to obtain topical formulations with improved photo-protection

Migdal effect and photon Bremsstrahlung: improving the sensitivity to light dark matter of liquid argon experiments

The search for dark matter weakly interacting massive particles with noble liquids has probed masses down and below a GeV/c^2. The ultimate limit is represented by the experimental threshold on the energy transfer to the nuclear recoil. Currently, the experimental sensitivity has reached a threshold equivalent to a few ionization electrons. In these conditions, the contribution of a Bremsstrahlung photon or a so-called Migdal electron due to the sudden acceleration of a nucleus after a collision might be sizable. In the present work, we use a Bayesian approach to study how these effects can be exploited in experiments based on liquid argon detectors. In particular, taking inspiration from the DarkSide-50 public spectra, we develop a simulated experiment to show how the Migdal electron and the Bremsstrahlung photon allow to push the experimental sensitivity down to masses of 0.1 GeV/c^2, extending the search region for dark matter particles of previous results. For these masses we estimate the effect of the Earth shielding that, for strongly interacting dark matter, makes any detector blind. Finally, we show how the sensitivity scales for higher exposure.Comment: 30 pages, 13 figures, 2 table

Fatal cranial injury in an individual from Messina (Sicily) during the times of the Roman Empire

Forensic and archaeological examinations of human skeletons can provide us with evidence of violence. In this paper, we present the patterns of two cranial lesions found on an adult male (T173) buried in a grave in the necropolis ‘Isolato 96’, Messina, Sicily, dating back to the Roman Empire (1st century BC - 1st century AD). The skull reveals two perimortem traumatic lesions, one produced by a sharp object on the right parietal bone and the other one on the left parietal bone, presumably the result of a fall. The interpretation of fracture patterns found in this cranium are an illustration of how forensic approaches can be applied with great benefit to archaeological specimens. 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved

Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2

Porcine cytochrome P450 (CYP) 1A2 was purified to electrophoretic homogeneity from the hepatic microsomes of -naphthoflavone-treated male pigs. In a reconstituted system, this enzyme showed a good catalytic activity towards caffeine, acetanilide, and methoxyresorufin, all known markers of mammalian CYP1A2. Using 30- and 50-rapid amplification of coding DNA (cDNA) ends (RACE), we amplified from the liver RNA of control pigs a full-length 1827 bp cDNA containing an open reading frame of 1548 bp which encoded a putative CYP1A2 protein of 516 amino acids and an estimated Mr of 58 380 Da. Reverse transcriptase-polymerase chain reaction (RT-PCR) experiments showed that the messenger RNA (mRNA) of CYP1A2 was expressed in liver, heart and nasal mucosa but not in lung, small intestine, kidney and brain. Using the pCW vector containing a N-terminal modified cDNA, pig CYP1A2 was expressed in Escherichia coli. 3-[(3-Chloroamidopropyl)dimethylmmonio]-1-propanesulfonate (CHAPS)-solubilized E. coli preparations expressing CYP1A2 produced a functionally isoform which, in a reconstituted system, was catalytically active toward ethoxyresorufin and methoxyresorufin showing Km\u27s similar to those obtained with CYP1A2 purified from pig liver or human recombinant CYP1A2. Taken together, these results demonstrate that domestic pigs have a functionally active CYP1A2 gene well expressed in the liver with biochemical properties quite similar to those corresponding to the human enzyme