Análise da vulnerabilidade ambiental do município de Barcarena-PA / Analysis of environmental vulnerability of Barcarena-PA

Analisar o meio ambiente é um desafio, por conta das diferentes forças que o influenciam e o moldam. No entanto, para o planejamento e gestão estratégica é necessário o monitoramento dessa variável, com esse viés surge a análise de vulnerabilidade ambiental, integrando dados de geomorfologia, pedologia, geologia, climatologia e uso e ocupação da terra, a partir das geotecnologias, utilizando como princípio norteador a metodologia de Crepani et al., considerado pesos diferentes as variáveis e considerando um fator chave – peso maior – por análise, obtendo produtos diferentes, comprovando que a metodologia utilizada deve ser adaptada por conta das condições geoambientais do local

408 Cases of Genital Ambiguity Followed by Single Multidisciplinary Team during 23 Years: Etiologic Diagnosis and Sex of Rearing

Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center. Results. There were 408 cases; 250 (61.3%) were 46,XY and 124 (30.4%) 46,XX and 34 (8.3%) had sex chromosomes abnormalities. 189 (46.3%) had 46,XY testicular DSD, 105 (25.7%) 46,XX ovarian DSD, 95 (23.3%) disorders of gonadal development (DGD), and 19 (4.7%) complex malformations. The main etiology of 46,XX ovarian DSD was salt-wasting 21-hydroxylase deficiency. In 46,XX and 46,XY groups, other malformations were observed. In the DGD group, 46,XY partial gonadal dysgenesis, mixed gonadal dysgenesis, and ovotesticular DSD were more frequent. Low birth weight was observed in 42 cases of idiopathic 46,XY testicular DSD. The average age at diagnosis was 31.7 months. The final sex of rearing was male in 238 cases and female in 170. Only 6.6% (27 cases) needed sex reassignment. Conclusions. In this large DSD sample with ambiguous genitalia, the 46,XY karyotype was the most frequent; in turn, congenital adrenal hyperplasia was the most frequent etiology. Malformations associated with DSD were common in all groups and low birth weight was associated with idiopathic 46,XY testicular DSD

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Níveis de sódio para codornas italianas destinadas à produção de carne

Com o objetivo de determinar os melhores níveis nutricionais de sódio para codornas italianas na fase 1 a 49 dias de idade, utilizaram-se 384 codornas com 1 dia de idade, distribuídas em delineamento inteiramente casualizado, com seis dietas contendo 0,07; 0,12; 0,17; 0,22; 0,27 ou 0,32% de sódio, avaliadas com oito repetições de oito aves por unidade experimental. Os níveis de sódio tiveram efeito quadrático sobre o consumo de ração, o ganho de peso e os rendimentos de carcaça e coxa+sobrecoxa, que foram melhores nos níveis de 0,257; 0,216; 0,207 e 0,191% de sódio, respectivamente. O aumento do nível de sódio na ração prejudicou a conversão alimentar, de forma linear, e aumentou a ingestão de água. Entretanto, a umidade das excretas e o rendimento de peito não foram afetados pelos níveis de sódio. Recomenda-se que as rações para codornas italianas na fase de 1 a 49 dia sejam formuladas com 0,22% de sódio

Acetylene plasma polymer treated by atmospheric dielectric barrier discharge

Plasma polymer films are very attractive for industrial applications in several sectors such as in the electronic, mechanic, biomedic, coating and others, due to its good adhesion, being insoluble in mild acids and bases and having a high crosslinking structure. This work reports the physical, structural, and surface properties of the polymer obtained from an acetylene plasma polymerization technique and treated by dielectric barrier discharge (DBD). The film was deposited in a reactor supplied by a radio-frequency power source at low pressure. After deposition, the nanofilms were treated in a DBD plasma reactor operating in air. The treatment times varied from 1 to 5 min. The analysis of molecular structure of the samples was investigated by FTIR spectroscopy, showing absorption bands in 3480, 2930, 1720, 1450 and 1380 cm(-1). The water contact-angle was investigated by goniometric technique and presented values from 5 to 65 degrees. The aging effect of these films was also studied. The alteration in the films surface morphology was assessed by an atomic force microscopy (AFM) which indicated that the roughness increased from 60 nm to 160 nm as a result of the DBD treatment. The refractive index of the samples presented values near 1.7, measured by UV-Visible spectroscopy. (C) 2014 Elsevier Ltd. All rights reserved