Barriers and Levels of Physical Activity in Patients With Symptomatic Peripheral Artery Disease: Comparison Between Women and Men

This cross-sectional study compared physical activity levels and barriers between 212 men and women with symptomatic peripheral artery disease. Physical activity was objectively measured by an accelerometer. Barriers to physical activity were obtained using a validated questionnaire. Women reported higher amounts of light physical activity (p < .001) and lower moderate–vigorous physical activity (p < .001) than men. Women more often reported barriers such as “not having anyone to accompany” (p = .006), “lack of money” (p = .018), “fear of falling or worsening the disease” (p = .010), “lack of security” (p = .015), “not having places to sit when feeling leg pain” (p = .021), and “difficulty in getting to a place to practice physical activity” (p = .015). In conclusion, women with symptomatic peripheral artery disease presented with lower amounts of moderate–vigorous activity and more barriers to activity than men. Strategies to minimize the barriers, including group actives and nonpainful exercises, are recommended for women with peripheral artery disease

Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice

Introduction The aim of this study was to investigate the effect of aerobic exercise (AE) in reducing bleomycin- induced fibrosis in mice of a Th2-dominant immune background (BALB/c). Methods BALB/c mice were distributed into: sedentary, control (CON), Exercise-only (EX), sedentary, bleomycin-treated (BLEO) and bleomycin-treated+exercised (BLEO+EX);(n = 8/group). Following treadmill adaptation, 15 days following a single, oro-tracheal administration of bleomycin (1.5U/kg), AE was performed 5 days/week, 60min/day for 4 weeks at moderate intensity (60% of maximum velocity reached during a physical test) and assessed for pulmonary inflammation and remodeling, and cytokine levels in bronchoalveolar lavage (BAL). Results At 45 days post injury, compared to BLEO, BLEO+EX demonstrated reduced collagen deposition in the airways (p<0.001) and also in the lung parenchyma (p<0.001). In BAL, a decreased number of total leukocytes (p<0.01), eosinophils (p<0.001), lymphocytes (p<0.01), macrophages (p<0.01), and neutrophils (p<0.01), as well as reduced pro-inflammatory cytokines (CXCL-1;p<0.01), (IL-1 beta;p<0.001), (IL-5;p<0.01), (IL-6;p<0.001), (IL-13;p<0.01) and pro-fibrotic growth factor IGF-1 (p<0.001) were observed. Anti-inflammatory cytokine IL-10 was increased (p<0.001). Conclusion AE attenuated bleomycin-induced collagen deposition, inflammation and cytokines accumulation in the lungs of mice with a predominately Th2-background suggesting that therapeutic AE (15-44 days post injury) attenuates the pro-inflammatory, Th2 immune response and fibrosis in the bleomycin model

Alcoolismo e dependência química na população idosa: um desafio para saúde pública brasileira

The objective of this study is to understand the main contexts about chemical dependency and alcoholism in old age. This is a narrative review of research on alcoholism in old age and, as a secondary objective, expose questions about chemical dependence in this same public. An in-depth search of articles was carried out in the Scientific Electronic Library Online (SciELO) and PubMed databases, with the following Health Sciences Descriptors (DeCS): Alcoholism; Chemical Dependency; Elderly Health; Illicit Substances. Articles were selected between the periods of 2010 to 2022, in Portuguese, to increase the level of relevance and quality of the review, given the scarcity of scientific studies on the subject. excess alcohol causes to the body, it becomes necessary to take primary action measures in society, in order to prevent the emergence of new users and the intensification of the problem. In addition, the importance of epidemiological studies and social research is perceived, especially in large Brazilian centers, after all, the population of Brazil ages every year, which can maximize the attraction of the elderly in drugs and in excess of alcohol.El objetivo de este estudio es comprender los principales contextos sobre dependencia química y alcoholismo en la vejez. Se trata de una revisión narrativa de investigaciones sobre el alcoholismo en la vejez y, como objetivo secundario, exponer interrogantes sobre la dependencia química en este mismo público. Se realizó una búsqueda en profundidad de artículos en las bases de datos Scientific Electronic Library Online (SciELO) y PubMed, con los siguientes Descriptores en Ciencias de la Salud (DeCS): Alcoholismo; Dependencia química; Salud del Anciano; Sustancias ilícitas. Los artículos fueron seleccionados entre los períodos de 2010 a 2022, en portugués, para aumentar el nivel de relevancia y calidad de la revisión, dada la escasez de estudios científicos sobre el tema. el exceso de alcohol provoca en el organismo, se hace necesario tomar medidas de acción primaria en la sociedad, a fin de evitar la aparición de nuevos consumidores y la agudización del problema. Además, se percibe la importancia de los estudios epidemiológicos y de la investigación social, especialmente en los grandes centros brasileños, después de todo, la población de Brasil envejece cada año, lo que puede maximizar la atracción de los ancianos en las drogas y el exceso de alcohol.Objetiva-se, neste estudo, compreender os principais contextos acerca da dependência química&nbsp; e o alcoolismo na terceira idade. Trata-se de uma revisão narrativa, na pesquisa sobre o alcoolismo na terceira idade e, como objetivo secundário, expor as questões acerca da dependencia quimica nesse mesmo público. Foi realizada uma profunda pesquisa de artigos nas bases de dados Scientific Electronic Library Online (SciELO) e PubMed, com os seguintes Descritores em Ciências da Saúde (DeCS): Alcoolismo; Dependência Química; Saúde do Idoso; Substâncias Ilícitas. &nbsp;Foram selecionados artigos entre os períodos de 2010 a 2022, no idioma Português, para ampliar o nível de relevância e a qualidade da revisão, visto a escassez de estudos científicos sobre a temática.. Considerando o prejuízo funcional que o uso de substâncias ilícitas e do excesso de álcool causam ao organismo, torna-se necessário medidas de ação primárias na sociedade, a fim de impedir o surgimento de novos usuários e intensificação do problema. Além disso, percebe-se a importância de estudos epidemiológicos e pesquisas sociais, sobretudo, nos grandes centros brasileiros, afinal, a população do Brasil envelhece a cada ano, podendo maximizar a atração da terceira idade nas drogas e no excesso de álcool.&nbsp

Functional and Cardiovascular Measurements in Patients With Peripheral Artery Disease: Comparison Between Men and Women

PURPOSE: To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD). METHODS: This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability. RESULTS: Women had lower claudication onset distance (P = .033) and 6MWT distance (P .05). Women had higher pulse pressure (P = .002), augmentation index (P .05). CONCLUSION: Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD

Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice

Introduction The aim of this study was to investigate the effect of aerobic exercise (AE) in reducing bleomycin- induced fibrosis in mice of a Th2-dominant immune background (BALB/c). Methods BALB/c mice were distributed into: sedentary, control (CON), Exercise-only (EX), sedentary, bleomycin-treated (BLEO) and bleomycin-treated+exercised (BLEO+EX);(n = 8/group). Following treadmill adaptation, 15 days following a single, oro-tracheal administration of bleomycin (1.5U/kg), AE was performed 5 days/week, 60min/day for 4 weeks at moderate intensity (60% of maximum velocity reached during a physical test) and assessed for pulmonary inflammation and remodeling, and cytokine levels in bronchoalveolar lavage (BAL). Results At 45 days post injury, compared to BLEO, BLEO+EX demonstrated reduced collagen deposition in the airways (p<0.001) and also in the lung parenchyma (p<0.001). In BAL, a decreased number of total leukocytes (p<0.01), eosinophils (p<0.001), lymphocytes (p<0.01), macrophages (p<0.01), and neutrophils (p<0.01), as well as reduced pro-inflammatory cytokines (CXCL-1;p<0.01), (IL-1 beta;p<0.001), (IL-5;p<0.01), (IL-6;p<0.001), (IL-13;p<0.01) and pro-fibrotic growth factor IGF-1 (p<0.001) were observed. Anti-inflammatory cytokine IL-10 was increased (p<0.001). Conclusion AE attenuated bleomycin-induced collagen deposition, inflammation and cytokines accumulation in the lungs of mice with a predominately Th2-background suggesting that therapeutic AE (15-44 days post injury) attenuates the pro-inflammatory, Th2 immune response and fibrosis in the bleomycin model

Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway

Submitted by Sandra Infurna ([email protected]) on 2016-12-01T11:17:20Z No. of bitstreams: 1 hugo_farianeto_etal_IOC_2016.pdf: 2748450 bytes, checksum: 98a1c02d5f24481572e9101bed50a250 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2016-12-01T11:42:37Z (GMT) No. of bitstreams: 1 hugo_farianeto_etal_IOC_2016.pdf: 2748450 bytes, checksum: 98a1c02d5f24481572e9101bed50a250 (MD5)Made available in DSpace on 2016-12-01T11:42:37Z (GMT). No. of bitstreams: 1 hugo_farianeto_etal_IOC_2016.pdf: 2748450 bytes, checksum: 98a1c02d5f24481572e9101bed50a250 (MD5) Previous issue date: 2016Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.University of São Paulo (USP). School of Medicine. Laboratory of Cellular Biology (LIM59). São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.University of São Paulo (USP). School of Medicine. Laboratory of Experimental Therapeutics (LIM 20). São Paulo, SP, Brazil.University of California Irvine. Institute for Memory Impairments and Neurological Disorders (MIND Institute). Irvine, CA, USA.University of São Paulo (USP). School of Medicine. Department of Pathology (LIM 05). São Paulo, SP, Brazil.University Hospital Freiburg. Department of Pneumology. COPD and Asthma Research Group. Freiburg, Germany.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.University of Tübingen. Department of Pneumology. Institute of Clinical and Experimental Transfusion Medicine (IKET). Tübingen, Germany.Nove de Julho University (UNINOVE). Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Laboratory of Pulmonary and Exercise Immunology (LABPEI). São Paulo, SP, Brazil.Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma

Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice

<div><p>Introduction</p><p>The aim of this study was to investigate the effect of aerobic exercise (AE) in reducing bleomycin-induced fibrosis in mice of a Th2-dominant immune background (BALB/c).</p><p>Methods</p><p>BALB/c mice were distributed into: sedentary, control (CON), Exercise-only (EX), sedentary, bleomycin-treated (BLEO) and bleomycin-treated+exercised (BLEO+EX); (n = 8/group). Following treadmill adaptation, 15 days following a single, oro-tracheal administration of bleomycin (1.5U/kg), AE was performed 5 days/week, 60min/day for 4 weeks at moderate intensity (60% of maximum velocity reached during a physical test) and assessed for pulmonary inflammation and remodeling, and cytokine levels in bronchoalveolar lavage (BAL).</p><p>Results</p><p>At 45 days post injury, compared to BLEO, BLEO+EX demonstrated reduced collagen deposition in the airways (p<0.001) and also in the lung parenchyma (p<0.001). In BAL, a decreased number of total leukocytes (p<0.01), eosinophils (p<0.001), lymphocytes (p<0.01), macrophages (p<0.01), and neutrophils (p<0.01), as well as reduced pro-inflammatory cytokines (CXCL-1; p<0.01), (IL-1β; p<0.001), (IL-5; p<0.01), (IL-6; p<0.001), (IL-13; p<0.01) and pro-fibrotic growth factor IGF-1 (p<0.001) were observed. Anti-inflammatory cytokine IL-10 was increased (p<0.001).</p><p>Conclusion</p><p>AE attenuated bleomycin-induced collagen deposition, inflammation and cytokines accumulation in the lungs of mice with a predominately Th2-background suggesting that therapeutic AE (15–44 days post injury) attenuates the pro-inflammatory, Th2 immune response and fibrosis in the bleomycin model.</p></div