Reflexões sobre a docência intercultural e inclusiva à luz das epistemologias de Freire e Maturana

Neste ensaio discutiremos docência intercultural e inclusiva à luz das epistemologias de Freire e Maturana. Como Metodologia, seguiremos um percurso de construção teórica e aproximações semânticas dos conceitos de interculturalidade e de inclusão, como uma contribuição à discussão sobre formação docente. Na continuidade, mostraremos que tanto a cultura, quanto a interculturalidade podem ser pensadas como redes linguísticas nas quais estão entrelaçadas o linguajar e o emocionar. O conceito de inclusão será discutido no âmbito mais geral das questões éticas, por acreditarmos que a aceitação do outro, enquanto legitimo outro, na convivência, é mais uma questão emocional do que racional. O realce às emoções e, no âmbito destas, o amor e a ética, enquanto preocupação com as consequências de nosso atuar sobre outros seres humanos, é fundamental para nossa análise, particularmente neste momento de ressurgimento da cultura do ódio e dos embates no campo dos direitos humanos e da educação inclusiva

Ocean Literacy, formal education, and governance: A diagnosis of Brazilian school curricula as a strategy to guide actions during the Ocean Decade and beyond

Ocean Literacy (OL) was proposed by UNESCO as a goal for the Decade of Ocean Science for Sustainable Development (Ocean Decade) aiming to (1) increase understanding of the importance of the ocean, (2) significantly influence communication on related subjects, and (3) facilitate informed and responsible decision-making about the ocean and its resources. Formal education is essential to expand the reach of OL, providing people with tools to engage in coastal and marine issues consciously and knowingly. To this end, content analysis of school curricula can help planning strategies, especially to empower citizens to implement public policies. This study assessed the extent to which OL-related terms and words are present in Brazilian curricular documents at federal (National Curriculum Parameters-PCNs and Common National Curriculum Base-BNCC) and regional (Federative Units curricular guidelines-RCs) levels. Qualitative (content analysis) and quantitative analyses (descriptive and non-parametric statistics, and multivariate analysis) were performed. The number of occurrences of OL-related words and terms were registered and counted. Nineteen words were found, totaling 797 citations (a frequency of 0.0001 in the total number of words referring to content). The number of citations were higher in BNCC-based RCs than in PCN-based RCs (Kruskal-Wallis test, p = 0.0009). Principal component analysis separated the documents into two groups, one related to BNCC-based RCs of Northeast, North and Midwest regions, with a higher number of OL related terms, and the other group with the PCN based RCs of these same regions plus those documents of Southeast and South regions (principal component 1 explaining 97.90% of the total variation and having 0.93 correlation with the total frequency of citations). General results indicated that Brazilian production on fields and themes related to OL is still concentrated in national journals, books, and booklets, thus with a limited impact. In same way although school curricula in Brazil have a larger number of topics on marine environments than do other countries, they showed heterogeneity among Federative Units, but generally with the topics still representing a very small fraction of Brazilian curricula. Thus, it is necessary to expand the contents related to the ocean and marine environments in curricula to provide students with basic knowledge about the importance and functions of these environments, as well as their conservation. Therefore, results here emphasize the need to implement OL to highlight the importance of knowledge of the oceans and enable citizens to discuss marine conservation policies and promote ocean sustainability. This study provided some strategies to increase OL in formal education and, hence, reach various stakeholders, which is fundamental to implement the United Nations Ocean Decade in Brazil and the Global South

Current status of stem cell therapy for liver diseases.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-04-01T16:13:15Z No. of bitstreams: 1 Souza BS Current status of....pdf: 211586 bytes, checksum: 8d5804b4dc69d201e1fb4ba685cd85a0 (MD5)Made available in DSpace on 2014-04-01T16:13:15Z (GMT). No. of bitstreams: 1 Souza BS Current status of....pdf: 211586 bytes, checksum: 8d5804b4dc69d201e1fb4ba685cd85a0 (MD5) Previous issue date: 2009Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalha˜es, , Recife, Pernambuco, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilLiver failure is one of the main causes of death worldwide and is a growing health problem. Since the discovery of stem cell populations capable of differentiating into specialized cell types, including hepatocytes, the possibility of their utilization in the regeneration of the damaged liver has been a focus of intense investigation. A variety of cell types were tested both in vitro and in vivo, but the definition of a more suitable cell preparation for therapeutic use in each type of liver lesions is yet to be determined. Here we review the protocols described for differentiation of stem cells into hepatocytes, the results of cell therapy in animal models of liver diseases, as well as the available data of the clinical trials in patients with advanced chronic liver disease

Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

AIM: To investigate the potential of bone marrow mononuclear cells (BM-MCs) in the regeneration of hepatic lesions induced by Schistosoma mansoni (S.mansoni) chronic infection

Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-10-09T19:06:49Z No. of bitstreams: 1 Oliveira SA Reduction of galectin-3....pdf: 510816 bytes, checksum: ce9cc2197c98efa3f557460a3a5f2bd1 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2014-10-09T19:07:03Z (GMT) No. of bitstreams: 1 Oliveira SA Reduction of galectin-3....pdf: 510816 bytes, checksum: ce9cc2197c98efa3f557460a3a5f2bd1 (MD5)Made available in DSpace on 2014-10-09T19:21:46Z (GMT). No. of bitstreams: 1 Oliveira SA Reduction of galectin-3....pdf: 510816 bytes, checksum: ce9cc2197c98efa3f557460a3a5f2bd1 (MD5) Previous issue date: 2012Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhaes. Recife, PE, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, BrasilBackground aims. Cirrhosis, end-stage liver disease, is caused by different mechanisms of injury, associated with persistent infl ammation. Galectin-3 is an important regulator of fi brosis that links chronic infl ammation to fi brogenesis. We investigated the role of bone marrow cell (BMC) transplantation in chronic infl ammation and hepatic fi brosis. Methods . Liver cirrhosis was induced by administration of carbon tetrachloride and ethanol to wild-type C57BL/6 or bone marrow chimeric mice. Bone marrow chimeras were generated by lethal irradiation and transplantation with BMC obtained from green fl uorescent protein (GFP )donors. Wild-type cirrhotic mice were transplanted with BMC without irradiation. Livers from chimeras and cirrhotic transplanted mice were obtained for evaluation of infl ammation, fi brosis and regulatory factors [galectin-3, matrix metallopeptidase (MMP)-9, tissue inhibitor of metalloproteinase (TIMP)-1 and transforming growth factor (TGF)- β ]. Results . The development of cirrhosis was associated with increased expression of galectin-3 by F4/80 cells and intense migration of BMC to the liver. Furthermore, when transplanted after the establishment of cirrhosis, BMC also migrated to the liver and localized within the fi brous septa. Two months after BMC therapy, cirrhotic mice had a signifi cant reduction in liver fi brosis and expression of type I collagen. We did not fi nd any difference in levels of TGF- β , TIMP-1 and MMP-9 between saline and BMC groups. However, the numbers of infl ammatory cells, phagocytes and galectin-3 cells were markedly lower in the livers of cirrhotic mice treated with BMC. Conclusions . Our results demonstrate an important role for BMC in the regulation of liver fi brosis and that transplantation of BMC can accelerate fi brosis regression through modulatory mechanism

Evaluation of Molecular Methods to Identify Chagas Disease and Leishmaniasis in Blood Donation Candidates in Two Brazilian Centers

In Brazil, blood donation is regulated by the Brazilian Ministry of Health, and all States follow the same protocol for clinical and laboratory screening. Brazil is an endemic country for Chagas disease (CD), caused by Trypanosoma cruzi, and for leishmaniasis, caused by a species of Leishmania spp. Screening for leishmaniosis is not routinely performed by blood banks. Given the antigenic similarity between T. cruzi and Leishmania spp., cross-reactions in serological tests can occur, and inconclusive results for CD have been found. The objective of this study was to apply molecular techniques, e.g., nPCR, PCR, and qPCR, to clarify cases of blood donation candidates with non-negative serology for CD and to analyze the difference between the melting temperature during real-time PCR using SYBR Green. Thirty-seven cases that showed non-negative results for CD using chemiluminescent microparticle immunoassay (CMIA) tests from blood banks in Campo Grande, MS, and Campinas, SP, were analyzed. In the serum samples, 35 samples were evaluated by ELISA, and 24.3% (9/35) showed positive results for CD. nPCR was able to detect 12 positive results in 35 samples (34.28%). qPCR for T. cruzi was quantifiable in the samples that showed a value ≥0.002 par eq/mL (parasite equivalents per milliliter), and in 35 samples, 11 (31.42%) were positive. Of all evaluated samples using the described tests (CMIA, ELISA, nPCR, and qPCR), 18 (48.6%) were positive for CD. For MCA by qPCR, the melting temperature was 82.06 °C ± 0.46 for T. cruzi and 81.9 °C ± 0.24 for Leishmania infantum. The Mann–Whitney test showed a significant value of p T. cruzi and L. infantum could not be considered due to temperature overlap. For leishmaniasis, of the 35 samples with non-negative serology for CD tested by the indirect fluorescent antibody test (IFAT), only one sample (2.85%) was positive (1:80). The PCR for Leishmania spp. was performed on 36 blood samples from donation candidates, and all were negative. qPCR for L. infantum showed 37 negative results for the 37 analyzed samples. The data presented here show the importance of performing two different tests in CD screening at blood banks. Molecular tests should be used for confirmation, thereby improving the blood donation system

Da colônia agrícola ao hospital-colônia: configurações para a assistência psiquiátrica no Brasil na primeira metade do século XX From the agricultural colony to the hospital-colony: configurations for psychiatric care in Brazil in the first half of the twentieth century

Discute os sentidos do modelo institucional das colônias na assistência psiquiátrica no Brasil, considerando suas diferentes configurações no contexto das políticas públicas de saúde na primeira metade do século XX. Toma como fio condutor a Colônia Juliano Moreira, fundada em 1924 no Rio de Janeiro. Demonstra o significado atribuído à concepção de colônia agrícola e sua importância na formatação da Colônia Juliano Moreira, para compreender como o ideário da colônia agrícola foi traduzido na concepção de hospital-colônia a partir dos anos 1940, quando essa instituição sofreu processo de acentuada expansão de sua estrutura física e de seus recursos terapêuticos.<br>The meanings given to the institutional model of the colonies in psychiatric care in Brazil are assessed, duly considering their different configurations in the context of public health policies in the first half of the twentieth century. The central thread of this analysis is the case of the Colônia Juliano Moreira, an institution founded in 1924 in Rio de Janeiro. It seeks to show the meaning attributed to the concept of agricultural colony and its importance in shaping the Colônia Juliano Moreira, in order to understand how the ideological precept of agricultural colony was translated into the concept of hospital-colony from the 1940s onwards, when this institution experienced a steady process of marked expansion of its physical structure and its therapeutic resources

Synthesis of piplartine analogs and preliminary findings on structure–antimicrobial activity relationship

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-23T14:10:54Z No. of bitstreams: 1 Fregnam AM Synthesis of piplartine.pdf: 1853217 bytes, checksum: 194ed12d0c7b2d0823762280877833fa (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-04-23T14:32:47Z (GMT) No. of bitstreams: 1 Fregnam AM Synthesis of piplartine.pdf: 1853217 bytes, checksum: 194ed12d0c7b2d0823762280877833fa (MD5)Made available in DSpace on 2018-04-23T14:32:48Z (GMT). No. of bitstreams: 1 Fregnam AM Synthesis of piplartine.pdf: 1853217 bytes, checksum: 194ed12d0c7b2d0823762280877833fa (MD5) Previous issue date: 2017FAPEMIG (APQ-01209-13), CAPES, CNPq and FINEP.Universidade Federal de Alfenas. Faculdade de Ciências Farmacêuticas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Química. Alfenas, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Faculdade de Ciências Farmacêuticas. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Química. Alfenas, MG, BrasilUniversidade Federal de Alfenas. Instituto de Química. Alfenas, MG, BrasilAbstract In this work it is described the synthesis, characterization and antimicrobial and toxicity evaluation of a series of analogs of piplartine, a piperamide found in Piper sp. The compounds structures were confirmed by infrared spectroscopy, 1H, 13C nuclear magnetic resonance, high resolution mass spectroscopy and were evaluated against strains of Candida spp., Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Derivative 24 was almost four-fold more potent (IC50: 48.83 μM) and five-fold less toxic (SI > 3) than piplartine (IC50: 189.2 μM; SI: 0.21) against Candida krusei, as well as two-fold more potent than fluconazole (IC50: 104.48 μM). This compound was also active against Candida tropicalis at 97.67 μM. Benzoyl derivative 17 was three-fold more potent (IC50: 85.2 μM) and more than five-fold less toxic (CC50: 231.71 μM) than piplartine (IC50: 315.33 μM and CC50: 41.14 μM) against Staphylococcus aureus. Given these findings, we have found analogs of piplartine which can be assumed as prototypes for the optimization and the development of new antimicrobial (compounds 24 and 17) agents