155 research outputs found
100m and 200m front crawl performance prediction based on anthropometric and physiological measurements
Background: The identification of the variables that are able to predict swimming performance is one of the main purposes of the âswimming scienceâ community. Research question: The aims of the study were: (i) to compare the anthropometric and physiological profiles of 100m and 200m front crawl swimmers and; (ii) to identify anthropometric and physiological variables that account for the prediction of the swimming performance at the 100m and 200m front crawl events. Methods: Twenty-six male swimmers were divided in two groups (12 for 100m group and 14 to 200m group). The swimmersâ personal best performance for the 100m and the 200m front crawl was converted to FINA points. The subjects performed a graded swimming test and an all-out test (100 or 200m maximal swims) in different days, in which physiological measures were evaluated. Forward step-by-step linear regression models were computed to predict swimming performance. The subjectsâ performances (season best and all-out test) were taken as dependent variables. The age, physiological and anthropometric measures were selected as independent variables. Results: Anthropometric and physiological profiles of 100 and 200m swimmers are different and the mean oxygen uptake during exercise combined with training experience may explain 200m front crawl best season performance with a high precision (â2% error). The models computed were able to predict from 44 % (i.e. 200m all-out bout) to 61 % (i.e. 200m season best) swimming performance. Predictive power of the models was less accurate in the 100m event (error > 10%). Conclusions: The authors conclude that the extent to which the physiological and anthropometric variables combine to predict performance probable is group-specific
Power corrections and renormalons in Drell-Yan production
The resummed Drell-Yan cross section in the double-logarithmic approximation
suffers from infrared renormalons. Their presence was interpreted as an
indication for non-perturbative corrections of order \lqcd/(Q(1-z)). We find
that, once soft gluon emission is accurately taken into account, the leading
renormalon divergence in the resummed cross section is cancelled by
higher-order perturbative contributions in the exponent of the resummed cross
section. From this evidence, `higher twist' corrections to the hard cross
section in Drell-Yan production should therefore intervene only at order
\lqcd^2/((Q^2 (1-z)^2) in the entire perturbative domain Q (1-z) > \lqcd.
We compare this result with hadronic event shape variables, comment on the
potential universality of non-perturbative corrections to resummed cross
sections, and on possible implications for phenomenology.Comment: 37 pages, LATEX, 3 figures as uudecoded fil
Are wearable heart rate measurements accurate to estimate aerobic energy cost during low-intensity resistance exercise?
The aim of the present study was to assess the accuracy of heart rate to estimate energy cost during eight resistance exercises performed at low intensities: half squat, 45° inclined leg press, leg extension, horizontal bench press, 45° inclined bench press, lat pull down, triceps extension and biceps curl. 56 males (27.5 ± 4.9 years, 1.78 ± 0.06 m height, 78.67 ± 10.7 kg body mass and 11.4 ± 4.1% estimated body fat) were randomly divided into four groups of 14 subjects each. Two exercises were randomly assigned to each group and subjects performed four bouts of 4-min constant-intensity at each assigned exercise: 12%, 16%, 20% and 24% 1-RM. Exercise and intensity order were random. Each subject performed no more than 2 bouts in the same testing session. A minimum recovery of 24h was kept between sessions. During testing VO2 was measured with Cosmed K4b2 and heart rate was measured with Polar V800 monitor. Energy cost was calculated from mean VO2 during the last 30-s of each bout by using the energy equivalent 1 ml O2 = 5 calorie. Linear regressions with heart rate as predictor and energy cost as dependent variable were build using mean data from all subjects. Robustness of the regression lines was given by the scatter around the regression line (Sy.x) and Bland-Altman plots confirmed the agreement between measured and estimated energy costs. Significance level was set at pâ€0.05. The regressions between heart rate and energy cost in the eight exercises were significant (p<0.01) and robustness was: half squat (Sy.x = 0,48 kcal·min-1), 45° inclined leg press (Sy.x = 0,54 kcal·min-1), leg extension (Sy.x = 0,59 kcal·min-1), horizontal bench press (Sy.x = 0,47 kcal·min-1), 45° inclined bench press (Sy.x = 0,54 kcal·min-1), lat pull down (Sy.x = 0,28 kcal·min-1), triceps extension (Sy.x = 0,08 kcal·min-1) and biceps curl (Sy.x = 0,13 kcal·min-1). We conclude that during low-intensity resistance exercises it is possible to estimate aerobic energy cost by wearable heart rate monitors with errors below 10% in healthy young trained males.This research was supported by Norte Portugal Regional Operational Programme (NORTE 2020), through Portugal 2020 and the European Regional Development Fund, NanoSTIMA, NORTE-01-0145- FEDER-000016 to VMR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersio
Daily leucine intake is positively associated with lower limb skeletal muscle mass and strength in the elderly.
Higher daily protein intake, with an emphasis on leucine content, is thought to mitigate age-related anabolic resistance, potentially counteracting age-related morphological and functional declines. The present study investigated potential associations between total daily leucine intake and dependent variables, including quadriceps muscle cross-sectional area (CSA) and maximum dynamic muscle strength (1-RM) in a cohort of healthy free-living older individuals of both sexes (n = 67; 34/33 men/women). Participants performed three 24-hour dietary recalls and underwent a magnetic resonance imaging exam followed by 1-RM tests. Our results demonstrate moderate associations between total daily leucine and both quadriceps CSA (r = 0.42; p = 0.004) and 1-RM (r = 0.45; p = 0.001). Furthermore, our exploratory biphasic linear regression analyses, adjusted for sex, age, and protein intake relative to body weight, revealed a plateau for daily leucine intake and muscle mass and muscle strength (around 7.6â8.0 g/dayâ1) in older adults. In conclusion, we demonstrated that total daily leucine intake is associated with muscle mass and strength in healthy older individuals and this association remains after controlling for multiple factors, including overall protein intake. Furthermore, our breakpoint analysis revealed non-linearities and a potential threshold for habitual leucine intake, which may help guide future research on the effects of chronic leucine intake in age-related muscle loss
A comparison of clinical pharmacodynamics of different administration schedules of oral topotecan (Hycamtin)
Prolonged exposure to topotecan in in vitro and in vivo experiments has
yielded the highest antitumor efficacy. An oral formulation of topotecan
with a bioavailability of 32-44% in humans enables convenient prolonged
administration. Pharmacokinetic/pharmacodynamic relationships from four
Phase I studies with different schedules of administration of oral
topotecan in 99 adult patients with malignant solid tumors refractory to
standard forms of chemotherapy were compared. Topotecan was administered
as follows: (a) once daily (o.d.) for 5 days every 21 days (29 patients);
(b) o.d. for 10 days every 21 days (19 patients); (c) twice daily (b.i.d.)
for 10 days every 21 days (20 patients); and (d) b.i.d. for 21 days every
28 days (31 patients). Pharmacokinetic analysis was performed in 55
patients using a validated high-performance liquid chromatographic assay
and noncompartmental pharmacokinetic me
Invisible Z-Boson Decays at e+e- Colliders
The measurement of the invisible Z-boson decay width at e+e- colliders can be
done "indirectly", by subtracting the Z-boson visible partial widths from the
Z-boson total width, or "directly", from the process e+e- -> \gamma \nu
\bar{\nu}. Both procedures are sensitive to different types of new physics and
provide information about the couplings of the neutrinos to the Z-boson. At
present, measurements at LEP and CHARM II are capable of constraining the
left-handed Z\nu\nu-coupling, 0.45 <~ g_L <~ 0.5, while the right-handed one is
only mildly bounded, |g_R| <= 0.2. We show that measurements at a future e+e-
linear collider at different center-of-mass energies, \sqrt{s} = MZ and
\sqrt{s}s ~ 170 GeV, would translate into a markedly more precise measurement
of the Z\nu\nu-couplings. A statistically significant deviation from Standard
Model predictions will point toward different new physics mechanisms, depending
on whether the discrepancy appears in the direct or the indirect measurement of
the invisible Z-width. We discuss some scenarios which illustrate the ability
of different invisible Z-boson decay measurements to constrain new physics
beyond the Standard Model
Comparison of different in situ hybridization techniques for the detection of various RNA and DNA viruses
In situ hybridization (ISH) is a technique to determine potential correlations between viruses and lesions. The aim of the study was to compare ISH techniques for the detection of various viruses in different tissues. Tested RNA viruses include atypical porcine pestivirus (APPV) in the cerebellum of pigs, equine and bovine hepacivirus (EqHV, BovHepV) in the liver of horses and cattle, respectively, and Schmallenberg virus (SBV) in the cerebrum of goats. Examined DNA viruses comprise canine bocavirus 2 (CBoV-2) in the intestine of dogs, porcine bocavirus (PBoV) in the spinal cord of pigs and porcine circovirus 2 (PCV-2) in cerebrum, lymph node, and lung of pigs. ISH with self-designed digoxigenin-labelled RNA probe
The Genome of the Netherlands: Design, and project goals
Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. The parent-offspring trios include adult individuals ranging in age from 19 to 87 years (mean=53 years; SD=16 years) from birth cohorts 1910-1994. Sequencing was done on blood-derived DNA from uncultured cells and accomplished coverage was 14-15x. The family-based design represents a unique resource to assess the frequency of regional variants, accurately reconstruct haplotypes by family-based phasing, characterize short indels and complex structural variants, and establish the rate of de novo mutational events. GoNL will also serve as a reference panel for imputation in the available genome-wide association studies in Dutch and other cohorts to refine association signals and uncover population-specific variants. GoNL will create a catalog of human genetic variation in this sample that is uniquely characterized with respect to micro-geographic location and a wide range of phenotypes. The resource will be made available to the research and medical community to guide the interpretation of sequencing projects. The present paper summarizes the global characteristics of the project
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