Interrogation de données hétérogènes dans les systèmes NoSQL orientés graphes

La flexibilité des systèmes NoSQL qui consiste à ne plus garantir un schéma unique pour un ensemble de données aboutit à des masses de données hétérogènes, rendant leur interrogation plus complexe pour les utilisateurs, qui doivent connaître les différentes formes (c'est-à-dire les différents schémas) des données manipulées. Cet article se focalise sur cette problématique de l'interrogation des données hétérogènes dans les systèmes NoSQL orientés graphes. L'enjeu est de simplifier pour les utilisateurs l'interrogation de ces masses de données hétérogènes en rendant transparente leur hétérogénéité

Connaissances des Anomalies du Tube Neural, Attitudes et Pratiques de Prévention chez les Femmes vues en Consultation prénatale, Région de Niamey-Niger, 2017: Knowledge, Attitudes and Prevention Practices of Neural Tube Anomalies in Women attending Prenatal Consultation in the Niamey-Niger Region 2017

Introduction: Les anomalies congénitales sont des anomalies fonctionnelles, structurelles ou métaboliques se produisant en intra-utérin et identifiables avant ou après la naissance. Au Niger, le domaine des anomalies congénitales n'a pas été suffisamment exploré. Notre objectif était de décrire les connaissances des anomalies du tube neural (ATN), les attitudes et les pratiques de prévention chez les femmes vues en consultation prénatale (CPN). Méthodes: Nous avons mené une enquête transversale de Février â Mars 2017 chez les femmes enceintes vues en CPN1 dans les maternités de Niamey. L'échantillon, calculé avec Open Epi était de 421. Les femmes enceintes ont été interviewées sur leurs connaissances des ATN, leurs attitudes et pratiques de prévention devant ces anomalies. Les données ont été collectées avec un questionnaire à travers les 5 districts sanitaires de la region de Niamey. Le nombre de femmes à enquêter par district a été alloué en tenant compte de l'importance relative des femmes en age de procréer (FAP) selon le district. Dans chaque district, il a été choisi par commodité, l'hôpital de district (HD), 2 maternités urbaines et 2 maternités rurales. Le nombre de femme par maternité a été déterminé selon le même procédé que dans les districts. A la maternité, les participantes ont été choisi de manière aléatoire. Des analyses univariées, bivariées et multivariées ont été réalisées. Des ratios de prévalence (RP), OR de prévalence (POR) à 95% ont été calculés. Les variables avec p<0,25 en analyse bivariée, ont été intégrées dans le modèle logistique multiple. Résultats: L'âge médian des enquêtées était de 25 ans. Il y avait 60,81% de scolarisées et 24,33% de primigestes. Environ 30,65% connaissaient les ATN ; 15,92% avaient de bonnes attitudes ; 41,81% avaient utilisées l'acide folique (AF). La tranche d'êge de 25-49ans a été un facteur indépendant de la connaissance des ATN (p=0,0008) ; pour les attitudes : il s'agit de l'âge (25-49ans) (p=0,03), la prise d'AF (p=0,0002) ; pour la pratique : le niveau d'instruction (p=0,01), l'information par les agents de santé (p< 0,0001), la connaissance d'autres sources d'AF (p=0,04). Conclusion: Il y avait une insuffisance de connaissances, d'attitudes et de pratiques de prévention devant les ATN chez les femmes enceintes. L'éducation continue, une politique d'enrichissement en AF de certains aliments s'impose. Background: Congenital anomalies are functional, structural or metabolic abnormalities occurring in the uterus and identifiable before or after birth. In Niger, the field of congenital anomalies has not been sufficiently explored. Our objective was to describe the knowledge of neural tube defects (NTDs), attitudes and prevention practices in women seen in antenatal care (ANC). Methods: We conducted a cross-sectional survey from February to March 2017 among pregnant women seen in CPN1 in maternity hospitals in Niamey. The sample, calculated with Open Epi, was 421. Pregnant women were interviewed on their knowledge of NTDs, their attitudes and prevention practices in the face of these anomalies. The data were collected with a questionnaire across the 5 health districts of the Niamey region. The number of women to be surveyed by district was allocated taking into account the relative importance of women of reproductive age (FAP) by district. In each district, it was chosen by convenience, the district hospital (HD), 2 urban maternities and 2 rural maternities. The number of women per maternity unit was determined using the same procedure as in the districts. In the maternity ward, the participants were chosen at random. Univariate, bivariate and multivariate analyzes were performed. 95% prevalence (PR), OR prevalence (POR) ratios were calculated. Variables with p <0.25 in bivariate analysis were included in the multiple logistic model. Results: The median age of the respondents was 25 years. There were 60.81% of school children and 24.33% of primigravidae. About 30.65% were familiar with ATNs; 15.92% had good attitudes; 41.81% had used folic acid (FA). The age group of 25-49 years was an independent factor of knowledge of NTDs (p = 0.0008); for attitudes: it is about age (25-49 years) (p = 0.03), AF intake (p = 0.0002); for practice: level of education (p = 0.01), information by health workers (p <0.0001), knowledge of other sources of FA (p = 0.04). Conclusion: There was a lack of knowledge, attitudes and prevention practices towards NTDs among pregnant women. Education continues, a policy of fortifying certain foods with AF is required

Spasmolytic Effects of Aqueous Extract of Sterculia setigera Delile on Isolated Rat Trachea

The spasmolytic properties of aqueous extract of Sterculia setigera was tested on Rat isolated trachea. Inhibition of the contraction was observed in presence of the aqueous extract (EC50 = 0.91mg/mL ± 0.02) after a pre contraction of the trachea by acetylcholine (10-5M). In the presence of propranolol (10-6M), the spasmolytic activity of the extract was inhibited. The EC50 value was 0.46mg/mL ± 0,11. The aqueous extract of Sterculia setigera also inhibited contraction induced by KCl (4.10-2 M) with EC50 value = 1.9mg/mL ± 0.48).  These results clearly show a relaxing effect of aqueous extract of Sterculia setigera on the trachea isolated from rat. This effect involves at least in part β-adrenergic receptor inhibition

Antioxidant and Antifatigue Properties of the Aqueous Extract of Moringa oleifera

The effects of the aqueous extract of Moringa oleifera on swimming performance and related biochemical parameters were investigated in male Wistar rats (130–132 g). Four groups of rats (16 per group) were fed a standard laboratory diet and given distilled water, 100, 200, or 400 mg/kg of extract, respectively, for 28 days. On day 28, 8 rats from each group were subjected to the forced swimming test with tail load (10% of body weight). The remaining 8 rats per group were subjected to the 90-minute free swim. Maximum swimming time, glycemia, lactamia, uremia, triglyceridemia, hepatic and muscle glycogen, hematological parameters, and oxidative stress parameters (superoxide dismutase, catalase, reduced glutathione, and malondialdehyde) were measured. Results. M. oleifera extract increased maximum swimming time, blood hemoglobin, blood glucose, and hepatic and muscle glycogen reserves. The extract also increased the activity of antioxidant enzymes and decreased the blood concentrations of malondialdehyde. Furthermore, it decreased blood concentrations of lactate, triglycerides, and urea. In conclusion, the antifatigue properties of M. oleifera extract are demonstrated by its ability to improve body energy stores and tissue antioxidant capacity and to reduce the tissue build-up of lactic acid

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study on mice, the extract of plant was administered once daily for 2 days at doses of 60, 120 and 240 mg / kg orally and 15, 30 and 60 mg / kg intraperitoneally after infection. Then, parameters of parasitaemia, packed cell volume (PCV), mean survival time and body weight of the mice treated with the extract were measured and compared with positive (diminazene aceturate) and negative (distilled water) controls for 7 days in a row. Results indicate that the aqueous extract of G. senegalensis leaves contains tannins, flavonoids, saponosides, reducing compounds and anthocyanosides, alkaloids and coumarins. LD50 of the extract are 1264.49 mg / kg by oral route and 316.22 mg / kg by intraperitoneal route. The doses of 240 mg / kg by oral route and 15 and 60 mg / kg by intraperitoneal route of aqueous extract showed a mean survival time (5 days) comparable to the positive control. Parasitaemia level increased in all mice tested except in mice treated with diminazene aceturate during the post-infestation period. During this period, PCV and body weight of all mice decreased by both routes of administration. These results of the study show the pharmacological utility of G. senegalensis leaves in the control of TAA by herders / pastoralists and suggest continuing further bio-guided studies to isolate the active components of the plant in order to improve their efficiency. Keywords: In vivo test; Trypanosoma brucei brucei; Guiera senegalensis leaves; phytochemical screening; acute toxicity

Etiology and risk factors for meningitis during an outbreak in Batié Health District, Burkina Faso, January-March 2016

Introduction: On 16 March 2016, Batié Health District notified the Burkina Faso Ministry of Health Surveillance unit of 12 suspected cases of meningitis. During the same period, Batié´s neighboring districts in Côte d'Ivoire and Ghana were experiencing a meningitis epidemic. We investigated to establish the etiology and risk factors for the disease and to recommend prevention and control measures. Methods: We conducted unmatched case control study. A case was any person living in Batié with fever (temp. ≥ 38.5°C) and any of the following: neck stiffness, neurological disorder, bulging fontanelle, convulsion during January to April 2016 with cerebrospinal fluid (CSF) positive to PCR. Controls were non sick household members, neighbors or friends to the cases. We analyzed the investigation and laboratory records. We included all confirmed cases and two neighborhood controls per case. We used a standard questionnaire to collect data. We analyzed data by Epi info 7 and calculated odds ratio (ORs),adjusted odds ratios (AOR) and 95% confidence interval. We proceeded to univariate, bivariate, multivariate and logistic regression analysis. Results: We interviewed 93 participants including 31 meningitis cases and 62 controls. The median age of cases was 8 years old [2 months-55 years] and 6.5 years old [5 months-51 years] for controls. Streptococcus pneumoniae 16(51.61%), Neisseria meningitidis W 14(45.16%) and Haemophilus influenzae b 1(3.23%) were the identified germs. The independent risk factors identified were travel to meningitis affected areas (Adjusted odd ratio(AOR)=12[2.3-60],p=0.0029); >5 persons sharing bedroom (AOR=5.7[1.5-22],p=0.012) and rhinopharyngitis (AOR=26[1.8-380],p=0.017). Conclusion: Streptococcus pneumoniae and Neisseria meningitidis W caused the outbreak in Batié. The risk factors were overcrowding, travel to affected areas, and rhinopharyngitis. We recommended reactive vaccination against Neisseria meningitidis W, limited travel to affected areas and ventilation of rooms

Schoolbag Weight and Low Back Pain: A Cross-Sectional Study among Children of Public and Private Primary Schools in Cameroon

Background: The issue of excessively heavy schoolbags remains a public health concern in Africa. This study aimed to determine the weight of schoolbags among students in the public and private sectors of Yaoundé city, Cameroon and identify factors associated with low back pain.Methods: A cross-sectional study was conducted during the first term of the 2020/2021 academic year in French-speaking private and public primary schools in Yaoundé city, Cameroon. The study involved 2000 pupils (8.41±2.11 years), with 1000 from the public sector and 1000 from the private sector. The variables analyzed included weight, height, and schoolbag weight. A questionnaire, developed specifically for this study and based on the Standardized Nordic Body Map Questionnaire, was used to collect socio-demographic information and assess potential musculoskeletal low back pain. A diagram was included to indicate the lower back area for reporting pain. The questionnaire was administered, and each student answered it, with assistance from the investigator if needed. Descriptive and inferential statistics, as well as multiple logistic regressions, were employed for data analysis.Results: The average weight of the children and their schoolbags was 28.51±8.04 kg and 4.04±1.72 kg, respectively. Nearly 45% of the pupils were carrying a schoolbag weighing more than 15% of their body weight, and 23% reported experiencing low back pain. Schoolbag weights ranging from 10-15% of body weight were associated with a threefold higher risk (OR=2.66; 95% CI=1.65 – 4.31; P<0.0001) of developing low back pain. Pupils in the public sector had a lower risk (OR=0.28; P<0.0001) of developing low back pain.Conclusion: Children in the private sector experience low back pain more frequently. Carrying heavy schoolbags is associated with low back pain among pupils