Heat and moisture balance simulation of a building with vapor-open envelope system for subtropical regions

Global warming and the resource depletion induced discussions on sustainable developments within the construction sector. Also the rapid urbanization in subtropical regions is becoming one of the most important global issues. Appropriate measures must be taken in such developments to avoid further damage to the environment. In this study, the heat and moisture balance simulation of building with a sustainable building envelope system for subtropical climate was proposed. In the moisture balance simulation the moisture buffering by the interior materials was taken into account. The prediction of moisture buffer value (MBV) of the interior finishing materials was attempted and validated by measurements. Subsequently, the whole building calculation was carried out and the contribution of the moisture buffering to the indoor comfort and energy consumption was investigated. The MBVs of the mineral-based materials were predicted with high accuracy. However, that of wood-based composite was much higher than the experimental value. In order to create a more accurate model, nonlinear moisture conductance should be accounted when modeling wood-based materials. The heating and cooling demand of a test house was 9.4 kWh/m2 and 14.5 kWh/m2, respectively. It was concluded that the utilization of the building envelope system has a high potential to provide sustainable houses in subtropical regions. In order to enhance both energy efficiency and indoor comfort of buildings in subtropical regions, there still is a strong need to develop a holistic method to find the optimum building design considering not only moisture buffering but also all the relevant factors. The presented model will be validated by in-situ measurements in the near futur

Optimization of Ladle Tilting Speed for Preventing Temperature Drops in the Die Casting Process

In die casting, molten metal poured into a shot sleeve is pressed into a mold by a plunger at high speed. The temperature of the metal drops significantly while it is being poured from the ladle to the shot sleeve, resulting in casting defects such as misrun flow lines. Although it is important to control the temperature at all stages of the process, a method for minimizing temperature loss has not yet been clarified to date. In this study, the cause of the temperature drop in the shot sleeve was clarified, and a method of optimizing the ladle tilting speed was proposed to prevent temperature drop. First, experiments were conducted to measure the decrease in metal temperature in the sleeve during pouring. These experiments revealed that the metal cools significantly from the moment it touches the shot sleeve. Therefore, the time from the first contact between the shot sleeve and the metal to the start of pouring was set as the objective function. A genetic algorithm was then used to derive the optimal ladle tilting speed pattern to suppress the temperature drop. This analysis confirmed that the metal was poured without flowing out or running ahead and that the immediate liquid level vibration after pouring was suppressed, thus ensuring stable pouring

Adaptive Optics Rest-Frame V-band Imaging of Lyman Break Galaxies at z~3: High-surface Density Disk-like Galaxies ?

In order to reveal the rest-frame V-band morphology of galaxies at z~3, we conducted AO-assisted K-band imaging observations of z~3 LBGs with Mv*-0.5 to Mv*+3.0 mag. LBGs brighter than Mv* have larger rHL (0.40") than the fainter LBGs (0.23") on average, and there is no bright LBGs with a small rHL. The LBGs brighter than Mv* have red rest-frame U-V colors (average of 0.2 mag) and most of the fainter LBGs show blue rest-frame U-V colors (average of -0.4 mag). The K-band peaks of some of the LBGs brighter than K=22.0 mag show significant shift from those in the optical images. The images of all but one of the LBGs with K<21.5 mag are fitted well with Sersic profile with n index less than 2, similar to disk galaxies in the local universe. Assuming that the LBGs have a disk-shape, we compared their size-luminosity and size-stellar mass relation with those of z=0 and z=1 disk galaxies. The LBGs are brighter than z=0 and z=1 disk galaxies at the same effective radius. The rest-frame V-band surface brightness of the LBGs are 2.2-2.9 mag and 1.2-1.9 mag brighter than the disk galaxies at z=0 and z=1, respectively. The size-stellar mass relation of the LBGs shows that the effective radii of the LBGs do not depend on their stellar mass. For the LBGs brighter than Mv*, the average surface stellar mass density is 3-6 times larger than those of the z=0 and z=1 disk galaxies. We also examine the profiles of the serendipitously observed DRGs. They are also fitted with the Sersic profiles with n<2. The implications of the dominance of n<2 population among galaxies at z~3 and the presence of the high surface stellar mass density disk systems are discussed.Comment: Accepted for publication in Astrophysical Journal Supplement. 38 pages, 26 postscript figures. Original version with high resolution figures is available from http://www.naoj.org/staff/akiyama/papers/LBG_AO.pd

The Subaru Deep Field Project: Lymanα\alpha Emitters at Redshift of 6.6

We present new results of a deep optical imaging survey using a narrowband filter ($NB921$) centered at $\lambda =$ 9196 \AA ~ together with $B$, $V$, $R$, $i^\prime$, and $z^\prime$ broadband filters in the sky area of the Subaru Deep Field which has been promoted as one of legacy programs of the 8.2m Subaru Telescope. We obtained a photometric sample of 58 Ly$\alpha$ emitter candidates at $z \approx$ 6.5 -- 6.6 among $\sim 180$ strong $NB921$-excess ($z^\prime - NB921 > 1.0$) objects together with a color criterion of $i^\prime - z^\prime > 1.3$. We then obtained optical spectra of 20 objects in our $NB921$-excess sample and identified at least nine Ly$\alpha$ emitters at $z \sim 6.5$ -- 6.6 including the two emitters reported by Kodaira et al. (2003). Since our Ly$\alpha$ emitter candidates are free from strong amplification of gravitational lensing, we are able to discuss their observational properties from a statistical point of view. Based on these new results, we obtain a lower limit of the star formation rate density of $\rho_{\rm SFR} \simeq 5.5 \times 10^{-4}$ $h_{0.7}$ $M_\odot$ yr$^{-1}$ Mpc$^{-3}$ at $z \approx 6.6$, being consistent with our previous estimate. We discuss the nature of star-formation activity in galaxies beyond $z=6$.Comment: 49 pages, 16 figures, PASJ, Vol. 57, No. 1, in pres

L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy

Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse reactions. Our previous study revealed that lenvatinib treatment reduced carnitine content and the expression of carnitine-related and oxidative phosphorylation (OXPHOS) proteins in the skeletal muscle of rats. Therefore, this study aimed to evaluate the effects of L-carnitine on myotoxic and anti-angiogenic actions of lenvatinib. Co-administration of L-carnitine in rats treated with lenvatinib for 2 weeks completely prevented the decrease in carnitine content and expression levels of carnitine-related and OXPHOS proteins, including carnitine/organic cation transporter 2, in the skeletal muscle. Moreover, L-carnitine counteracted lenvatinib-induced protein synthesis inhibition, mitochondrial dysfunction, and cell toxicity in C2C12 myocytes. In contrast, L-carnitine had no influence on either lenvatinib-induced inhibition of vascular endothelial growth factor receptor 2 phosphorylation in human umbilical vein endothelial cells or angiogenesis in endothelial tube formation and mouse aortic ring assays. These results suggest that L-carnitine supplementation could prevent lenvatinib-induced muscle toxicity without diminishing its antineoplastic activity, although further clinical studies are needed to validate these findings

Particle-hole symmetry and transport properties of the flux state in underdoped cuprates

Transport properties are studied for the flux state with the gauge flux $\phi$ per plaquett, which may model the underdoped cuprates, with the emphasis on the particle-hole and parity/chiral symmetries.This model is reduced to the Dirac fermions in (2+1)D with a mass gap introduced by the antiferromagnetic (AF) long range order and/or the stripe formation. Without the mass gap, the Hall constant $R_H$ and the thermopower $S$ obey two-parameter scaling laws, and show the strong temperature dependence due to the recovery of the particle-hole symmetry at high temperature. The $x$-dependences of $\sigma_{xx} (\propto \sqrt{x})$ and $\sigma_{xy}$ (independent of $x$) are in a sharp contradiction with the experiments. (Here $x$ is the hole concentration.) Therefore there is no signature of the particle-hole symmetry or the massless Dirac fermions in the underdoped cuprates even above the Neel temperature $T_N$. With the mass gap introduced by the AF order, there occurs the parity anomaly for each of the Dirac fermions. However the contributions from different valleys and spins cancel with each other to result in no spontaneous Hall effect even if the time-reversal symmetry is broken with $\phi \ne \pi$. The effects of the stripes are also studied. The diagonal and vertical (horizontal) stripes have quite different influence on the transport properties. The suppression of $R_H$ occurs at low temperature only when (i) both the AF order and the vertical (horizontal) stripe coexist, and (ii) the average over the in-plane direction is taken. Discussions on the recent experiments are given from the viewpoint of these theoretical results.Comment: RevTeX, 14 pages, 11 figure

Establishment of a reborn MMV-microarray technology: realization of microbiome analysis and other hitherto inaccessible technologies

BACKGROUND: With the accelerating development of bioscience, the problem of research cost has become important. We previously devised and developed a novel concept microarray with manageable volumes (MMV) using a soft gel. It demonstrated the great potential of the MMV technology with the examples of 1024-parallel-cell culture and PCR experiments. However, its full potential failed to be expressed, owing to the nature of the material used for the MMV chip. RESULTS: In the present study, by developing plastic-based MMVs and associated technologies, we introduced novel technologies such as C2D2P (in which the cells in each well are converted from DNA to protein in 1024-parallel), NGS-non-dependent microbiome analysis, and other powerful applications. CONCLUSIONS: The reborn MMV-microarray technology has proven to be highly efficient and cost-effective (with approximately 100-fold cost reduction) and enables us to realize hitherto unattainable technologies

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

金沢大学医薬保健研究域医学系Insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and fatty acids metabolism remain unclear. We investigated biological pathways that have the potential to induce insulin resistance in mice fed a high-fat diet (HFD). We demonstrate that the pathways for reactive oxygen species (ROS) production and oxidative stress are coordinately up-regulated in both the liver and adipose tissue of mice fed an HFD before the onset of insulin resistance through discrete mechanism. In the liver, an HFD up-regulated genes involved in sterol regulatory element binding protein 1c-related fatty acid synthesis and peroxisome proliferator-activated receptor α-related fatty acid oxidation. In the adipose tissue, however, the HFD down-regulated genes involved in fatty acid synthesis and up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Furthermore, increased ROS production preceded the elevation of tumor necrosis factor-α and free fatty acids in the plasma and liver. The ROS may be an initial key event triggering HFD-induced insulin resistance. © 2008 Elsevier Inc. All rights reserved