Distribution cost analysis methodologies, 1901-1941

The attempt to develop cost analysis methodologies for the marketing function began at the turn of the century. Early attempts followed the pattern of factory cost analysis and progress was slow until the break-through in the years 1940- 1941

Natural Resource Planning And Management1

Access to the best possible information by land planners, land managers, legislators, and other decision-makers is made more difficult by the growing complexity and large scope of land use conflicts. The Land Use Analysis Laboratory, an interdisciplinary research team, has as its general purpose the development of tools to provide increased access to land information. Because the volume and complexity of the necessary data are two of the principal obstacles to full access to land information, the use of computers is an important means of increasing the availability and versatility of land information

Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria

The synthesis and microbiological evaluation of 7-, 8- and 9-nitro-1,2,4-trihalogenophenoxazin-3-one substrates with potential in the detection of nitroreductase-expressing pathogenic microorganisms are described. The 7- and 9-nitrotrihalogenophenoxazinone substrates were reduced by most Gram negative microorganisms and were inhibitory to the growth of certain Gram positive bacteria; however, the majority of Gram positive strains that were not inhibited by these agents, along with the two yeast strains evaluated, did not reduce the substrates. These observations suggest there are differences in the active site structures and substrate requirements of the nitroreductase enzymes from different strains; such differences may be exploited in the future for differentiation between pathogenic microorganisms. The absence of reduction of the 8-nitrotrihalogenophenoxazinone substrates is rationalized according to their electronic properties and correlates well with previous findings

Gravitational Geons Revisited

A careful analysis of the gravitational geon solution found by Brill and Hartle is made. The gravitational wave expansion they used is shown to be consistent and to result in a gauge invariant wave equation. It also results in a gauge invariant effective stress-energy tensor for the gravitational waves provided that a generalized definition of a gauge transformation is used. To leading order this gauge transformation is the same as the usual one for gravitational waves. It is shown that the geon solution is a self-consistent solution to Einstein's equations and that, to leading order, the equations describing the geometry of the gravitational geon are identical to those derived by Wheeler for the electromagnetic geon. An appendix provides an existence proof for geon solutions to these equations.Comment: 18 pages, ReVTeX. To appear in Physical Review D. Significant changes include more details in the derivations of certain key equations and the addition of an appendix containing a proof of the existence of a geon solution to the equations derived by Wheeler. Also a reference has been added and various minor changes have been mad

Hawking radiation of massive modes and undulations

We compute the analogue Hawking radiation for modes which posses a small wave vector perpendicular to the horizon. For low frequencies, the resulting mass term induces a total reflection. This generates an extra mode mixing that occurs in the supersonic region, which cancels out the infrared divergence of the near horizon spectrum. As a result, the amplitude of the undulation (0-frequency wave with macroscopic amplitude) emitted in white hole flows now saturates at the linear level, unlike what was recently found in the massless case. In addition, we point out that the mass introduces a new type of undulation which is produced in black hole flows, and which is well described in the hydrodynamical regime.Comment: 37 pages, 8 figures, published versio

The architecture of the left ventricular myocytes relative to left ventricular systolic function

Objective: Mural thickening, combined with longitudinal and circumferential shortening, and apical along with basal twisting are critical components of the left ventricular systolic deformation that contribute to ventricular ejection. It is axiomatic that the spatial alignment of the actively contracting aggregates of myocytes must play a major role in the resulting ventricular deformation. The need to conserve functional global myocytic architecture, therefore, is an important aspect of the surgical manoeuvres affecting ventricular mass and geometry. To investigate the influence of the global alignment of the myocytes on ventricular contraction, we used a mathematical model simulating the large deformations produced by systolic contraction of the left ventricle of a human heart. Methods: The alignment and meshing of the myocytes within their supporting fibrous matrix cause mechanical anisotropy, which was included in the mathematical model in the form of a unit vector field, constructed from the measured trajectories of aggregated myocytes in an autopsied human heart. The relationship between ventricular structure and ventricular dynamics was assessed by analysing the influence of systematic deviations of the orientation of the myocytes from their original alignment, in longitudinal as well as radial directions, on the distribution of stress and strain within the myocardium, as well as on the ejection fraction. In addition, simplified idealised geometries were used to investigate the influence of the overall geometrical modifications. Results: Left ventricular function proved to be robust with respect to small-to-moderate rotational variations in myocytic alignment, up to 14°, a finding which we attribute to an equalising effect of the non-uniform anisotropic pattern found in a real heart involving substantial local irregularities in the architecture of the aggregated myocytes. Severe deterioration of function occurred only when deviations in alignment exceeded 30°. Conclusions: Our findings substantiate the concept of the myocardial walls representing a continuous three-dimensional meshwork, with the absence of any intermediate structures such as discrete bands or tracts extending over the ventricles, which could be destroyed surgically, thereby adversely affecting systolic function. With appropriate indications, they also support the validity of the surgical procedures performed to reduce ventricular radius and therefore to reduce mural stres