Detecting solar axions using Earth's magnetic field

We show that solar axion conversion to photons in the Earth's magnetosphere can produce an x-ray flux, with average energy \sim 4 keV, which is measurable on the dark side of the Earth. The smallness of the Earth's magnetic field is compensated by a large magnetized volume. For axion masses < 10^{-4} eV, a low-Earth-orbit x-ray detector with an effective area of 10^4 cm^2, pointed at the solar core, can probe the photon-axion coupling down to 10^{-11} GeV^{-1}, in one year. Thus, the sensitivity of this new approach will be an order of magnitude beyond current laboratory limits.Comment: 3 pages, 1 figure, typos corrected, references adde

FINDCHIRP: an algorithm for detection of gravitational waves from inspiraling compact binaries

Matched-filter searches for gravitational waves from coalescing compact binaries by the LIGO Scientific Collaboration use the FINDCHIRP algorithm: an implementation of the optimal filter with innovations to account for unknown signal parameters and to improve performance on detector data that has nonstationary and non-Gaussian artifacts. We provide details on the FINDCHIRP algorithm as used in the search for subsolar mass binaries, binary neutron stars, neutron star-black hole binaries, and binary black holes.Comment: 19 pages, 1 figure, journal version with Creative Commons 4.0 open-access license adde

A power filter for the detection of burst sources of gravitational radiation in interferometric detectors

We present a filter for detecting gravitational wave signals from burst sources. This filter requires only minimal advance knowledge of the expected signal: i.e. the signal's frequency band and time duration. It consists of a threshold on the total power in the data stream in the specified signal band during the specified time. This filter is optimal (in the Neyman-Pearson sense) for signal searches where only this minimal information is available.Comment: 3 pages, RevTeX, GWDAW '99 proceedings contribution, submitted to Int. J. Modern Phys.

Effect of matrix solidification on the structure formation in electromagnetic suspensions

For suspensions with electromagnetic particles exposed to an external field, we examine the effect of the solidification of the suspending medium on the formation of particle structures, representative of the curing of a photo-reactive resin during stereolithography. To that end, Brownian Dynamics (BD) simulations are examined in which the solidification of the suspending medium can be incorporated by increasing its viscosity in the course of time. For illustrative purposes, it is assumed that the viscosity function is known apriori in explicit and parametrized form, however, experimental data can be used as well. It is demonstrated that one can study the effects of the viscosity increase by a transformation of time, akin to the time-temperature superposition principle, but here also in the presence of thermal noise on the suspended particles. Therefore, instead of performing BD simulations with a continuously increasing viscosity (computationally inefficient), we advocate performing simulations at a constant (low) viscosity and subsequently transform time (nonlinearly) for re-interpretation of the simulation results. So doing, one can predict the formation of particle structures during on-going solidification of the suspending medium. In practice, the viscosity increase is so drastic that further evolution of the particle structure can be considered as arrested after the characteristic transition-time of the viscosity is reached. Semi-quantitative rules of thumb are formulated for the 3D-printing practitioner

The Role of Sister Cities’ Staff Exchanges in Developing “Learning Cities”: Exploring Necessary and Sufficient Conditions in Social Capital Development Utilizing Proportional Odds Modeling

In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building “learning cities” through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal sister city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit Link approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

The three enzymes that constitute the de novo thymidylate synthesis pathway in mammals, cytoplasmic serine hydroxymethyltransferase (SHMT1), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR) undergo sumoylation and nuclear import during S-phase. In this study, we demonstrate that purified intact mouse liver nuclei convert dUMP to dTMP in the presence of NADPH and serine. Neither nuclear extracts nor intact nuclei exposed to aminomethylphosphonate, a SHMT inhibitor, exhibit thymidylate synthesis activity. Nuclei isolated from Shmt1−/− mouse livers retained 25% of thymidylate synthesis activity exhibited by nuclei isolated from wild type mice. This residual activity was due to the presence of a cytoplasmic/nuclear isozyme of SHMT encoded by Shmt2. Shmt2 is shown to encode two transcripts, one which encodes a protein that localizes exclusively to the mitochondria (SHMT2), and a second transcript that lacks exon 1 and encodes a protein that localizes to the cytoplasm and nucleus during S-phase (SHMT2α). The ability of Shmt2 to encode a cytoplasmic isozyme of SHMT may account for the viability of Shmt1−/− mice and provide redundancy that permitted the expansion of the human SHMT1 L474F polymorphism that impairs SHMT1 sumoylation and nuclear translocation

Bedtime for Democracy: The Power Elite as Sovereign Aristocracy in Neoliberal Amerika

Leftist political theory in Amerika has struggled to understand the two most important issues facing us today: sovereignty and neoliberalism. In their efforts to understand neoliberalism, most scholars rely on either neo-Marxist or poststructuralist (Foucault) approaches, and in their efforts to understand sovereignty, scholars commonly turn to Carl Schmitt’s legalistic notion of sovereignty. Unfortunately, these approaches cannot produce a sufficiently descriptive account of sovereignty in neoliberal Amerika, which is why I turn to the sociological political theory of C. Wright Mills, articulating a power elite theory of neoliberalism that provides a ground for identifying the aristocratic structure of sovereignty in our historical period. First, I provide an empirically-supported account of the development of the Amerikan power elite from the 1950s to today. Rather than consisting of three directorates as Mills observed in the 1950s – political, economic, and military – the power elite today rules from only two directorates: the Corporate-Juridical Directorate and the Military-Juridical Directorate. Second, I turn to early modern political theory to identify two modes of sovereignty: legislative sovereignty and executive sovereignty, the latter of which consists of two principles, executive enforcement (of law) and executive prerogative. Third, I argue that, in neoliberal Amerika, the Corporate-Juridical Directorate wields legislative sovereignty and the Military-Juridical Directorate wields executive sovereignty. Ultimately, the Left should abandon its reliance on pluralistic and legalistic notions in order to understand the aristocratic sovereignty of the power elite

Levinas and the Anticolonial

Over the last two decades, the various attempts to “radicalize” Levinas have resulted in two interesting and often separated debates: one the one hand, there is the debate regarding the relationship between Levinas and colonialism and racism, and on the other hand, there is the debate regarding the relationship between Levinas and Judaism. Whether scholars interested in issues of colonialism disregard Levinas's Judaism or use his "subaltern" identity to challenge European hegemony, they do not take seriously the Jewish content of Levinas's thought. In this essay, I challenge the prevailing postcolonial orinetation of the Levinas-colonialism conversation, approaching Levinas's phenomenology from an anticolonial perspective. I will use Frantz Fanon’s dualistic understanding of the colonial world to evaluate the adequacy of Levinas’s phenomenology in describing the ontological structure of the colony and the historical experience of the colonized within it. Levinas’s incomplete understanding of the Holocaust as colonialism contributes to his failure to recognize the dividing line of colonial ontology, the zone of nonbeing, the non-human status of the colonized, and ultimately contributes to the insufficiency of his phenomenology to describe the colony. Because my purpose is not to reject Levinas’s thought in general but to encourage a new approach to his work, in the conclusion I will gesture toward the need for an anticolonial reading of Levinas’s project for Jewish education

Mthfs is an Essential Gene in Mice and a Component of the Purinosome

Tetrahydrofolates (THF) are a family of cofactors that function as one-carbon donors in folate-dependent one-carbon metabolism, a metabolic network required for the de novo synthesis of purines, thymidylate, and for the remethylation of homocysteine to methionine in the cytoplasm. 5-FormylTHF is not a cofactor in one-carbon metabolism, but serves as a storage form of THF cofactors. 5-formylTHF is mobilized back into the THF cofactor pool by methenyltetrahydrofolate synthetase (MTHFS), which catalyzes the irreversible and ATP-dependent conversion 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate. Mthfs is not an essential gene in Arabidopsis, but MTHFS expression is elevated in animal tumors, enhances de novo purine synthesis, confers partial resistance to antifolate purine synthesis inhibitors and increases rates of folate catabolism in mammalian cell cultures. However, the mechanisms underlying these effects of MTHFS expression have yet to be established. The purpose of this study was to investigate the role and essentiality of MTHFS in mice. Mthfs was disrupted through the insertion of a gene trap vector between exons 1 and 2. Mthfsgt/+ mice were fertile and viable. No Mthfsgt/gt embryos were recovered from Mthfsgt/+ intercrosses, indicating Mthfs is an essential gene in mice. Tissue MTHFS protein levels are decreased in both Mthfsgt/+ and Mthfs+/+ mice placed on a folate and choline deficient diet, and mouse embryonic fibroblasts from Mthfsgt/+ embryos exhibit decreased capacity for de novo purine synthesis without impairment in de novo thymidylate synthesis. MTHFS was shown to co-localize with two enzymes of the de novo purine synthesis pathway in HeLa cells in a cell cycle-dependent manner, and to be modified by the small ubiquitin-like modifier (SUMO) protein. Mutation of the consensus SUMO modification sites on MTHFS eliminated co-localization of MTHFS with the de novo purine biosynthesis pathway under purine-deficient conditions. The results from this study indicate that MTHFS enhances purine biosynthesis by delivering 10-formylTHF to the purinosome in a SUMO-dependent fashion