Gender Equity in Intercollegiate Athletics: Determinants of Title IX Compliance

Using new data on intercollegiate athletes, this article shows that recent improvement in Title IX compliance among NCAA Division I institutions was previously overestimated, and provides the first estimates of compliance in Divisions II and III. In addition, regression analyses investigate how institutional characteristics relate to the extent of non-compliance

Vaginal Microbicides: Detecting Toxicities in Vivo that Paradoxically Increase Pathogen Transmission

BACKGROUND: Microbicides must protect against STD pathogens without causing unacceptable toxic effects. Microbicides based on nonoxynol-9 (N9) and other detergents disrupt sperm, HSV and HIV membranes, and these agents are effective contraceptives. But paradoxically N9 fails to protect women against HIV and other STD pathogens, most likely because it causes toxic effects that increase susceptibility. The mouse HSV-2 vaginal transmission model reported here: (a) Directly tests for toxic effects that increase susceptibility to HSV-2, (b) Determines in vivo whether a microbicide can protect against HSV-2 transmission without causing toxicities that increase susceptibility, and (c) Identifies those toxic effects that best correlate with the increased HSV susceptibility. METHODS: Susceptibility was evaluated in progestin-treated mice by delivering a low-dose viral inoculum (0.1 ID50) at various times after delivering the candidate microbicide to detect whether the candidate increased the fraction of mice infected. Ten agents were tested – five detergents: nonionic (N9), cationic (benzalkonium chloride, BZK), anionic (sodium dodecylsulfate, SDS), the pair of detergents in C31G (C14AO and C16B); one surface active agent (chlorhexidine); two non-detergents (BufferGel®, and sulfonated polystyrene, SPS); and HEC placebo gel (hydroxyethylcellulose). Toxic effects were evaluated by histology, uptake of a 'dead cell' dye, colposcopy, enumeration of vaginal macrophages, and measurement of inflammatory cytokines. RESULTS: A single dose of N9 protected against HSV-2 for a few minutes but then rapidly increased susceptibility, which reached maximum at 12 hours. When applied at the minimal concentration needed for brief partial protection, all five detergents caused a subsequent increase in susceptibility at 12 hours of ~20–30-fold. Surprisingly, colposcopy failed to detect visible sign of the N9 toxic effect that increased susceptibility at 12 hours. Toxic effects that occurred contemporaneously with increased susceptibility were rapid exfoliation and re-growth of epithelial cell layers, entry of macrophages into the vaginal lumen, and release of one or more inflammatory cytokines (Il-1β, KC, MIP 1α, RANTES). The non-detergent microbicides and HEC placebo caused no significant increase in susceptibility or toxic effects. CONCLUSION: This mouse HSV-2 model provides a sensitive method to detect microbicide-induced toxicities that increase susceptibility to infection. In this model, there was no concentration at which detergents provided protection without significantly increasing susceptibility.JHU Woodrow Wilson Fellowship; National Institutes of Health (Program Project A1 45967

Gender Equity in Intercollegiate Athletics: Determinants of Title IX Compliance

[Excerpt The year 2002 marked the 30th anniversary of the passage of Title IX, which prohibits discrimination by gender in any federally funded educational activity. Although the scope of Title IX includes all aspects of education, the application of Title IX to college athletics has been especially complicated because athletics programs, unlike most academic classes, usually are sex-segregated by sport. As explained in more detail below, Title IX essentially requires that all institutes of higher education provide student access to sport participation on a gender-neutral basis. As a result, athletic opportunities for female undergraduates have expanded significantly since 1972. For example, the female share of college athletes rose to 42% in 2001/02 from only 15% in 1972 (U.S. Department of Education, 1997, 2003). Despite this progress, gender equity is far from complete. Estimates from our data show that at the average institution in 2001/02, women comprised 55% of all students but only 42% of the varsity athletes. Our research describes the level of noncompliance with Title IX, as measured by the proportionality gap, between 1995/96 and 2001/02, and then investigates why some institutions perform better than others do on this measure of gender equity. One important contribution of this article is the introduction of a new data set developed by the authors that includes information on athletic offerings and other institutional characteristics for the 1995/96 and 2001/02 academic years. Our data represent a substantial improvement over previous data because we include institutions in Divisions I, II, and III and adjust for changes in how institutions report athletic participation over the period; previous research focused solely on Division I institutions and did not adjust for reporting differences. We show that these data differences are important: Reliance on unadjusted data from Division I institutions results in large overestimates of the improvement in compliance at NCAA institutions during the late 1990s. Our data also include a rich set of explanatory variables that we use in regression analyses to explain the extent of institutional noncompliance. We examine the determinants of the proportionality gap by estimating OLS cross-section regressions (with and without conference fixed effects) at two points in time (1995/96 and 2001/02) and first-difference regressions for changes over the period

Children Served by MaineCare, 2007: Survey Findings

This report presents findings from a telephone survey of children currently enrolled in or recently disenrolled from MaineCare, the State‘s Medicaid and State Children‘s Health Insurance Program (SCHIP). The sample was randomly selected, and stratified to include children enrolled in MaineCare through the Medicaid eligibility category, and through two SCHIP eligibility categories, Medicaid Expansion and the Separate Child Health Program (CHP). 1 These three eligibility categories include children ages 18 or under living in households with income up to 200% of the Federal Poverty Level. Income eligibility limits are lowest for the Medicaid eligibility category, followed by the Medicaid Expansion and the Separate Child Health Program categories.2 Between May and September 2007 telephone interviews were completed with 1,531 parents of enrolled children and 259 parents of disenrolled children

Professional Learning in the Workplace : A Case in Study in Higher Education.

With the aim of contributing to understanding of learning in the workplace, this thesis uses a case study approach to explore the learning of a newly-formed community of practice in the complex environment of higher education. Social theories of learning, based on a paradigm where learning is part of a social activity, have emerged to explain how individuals and groups develop knowledge in the workplace. Whilst studies to date have focussed on established communities of practice, very little work has examined how a new group, with no established experts or ways of working, learns in the workplace. Analysis of interview data from a newly-formed group of eleven learning and teaching co-ordinators revealed a series of practice clusters in which participants appear to engage. Organisationally-derived practice clusters, categorised as systemic, project and knowledge construction practices, relate to tasks identified on the job description. Data analysis also revealed four clusters of agency-derived practice: navigation practices, legitimation practices, affirmation practices and motivation practices. As participants engage in both organisationally-derived and agency-derived practice clusters, they draw upon, and in turn develop, resources which I have grouped into resource clusters comprising knowledge resources and enabling resources, specifically support, guidance, feedback and confidence. The contribution of the research is its focus on the learning of a newly-formed community of practice. Specifically, I propose that to understand the learning of such a community, it is useful to focus on the complex dynamic between the practice clusters in which the members engage and the resource clusters developed and drawn upon. The influence of both individual and organisational factors should be considered, and whilst neither should be given priority, it is likely that the individual will be more proactive, particularly in seeking out support, than a member of an established community of practice

Rapid assessment of tissue nitrogen in cultivated Gracilaria gracilis (Rhodophyta) and Ulva lactuca (Chlorophyta)

Tissue nitrogen content and thallus colour were quantified using a rapid assessment method based on the Pantone® matt uncoated formula guide for raft-cultivated Gracilaria gracilis Steentoft Irvine et Farnham at Saldanha Bay and tank-cultivated Ulva lactuca Linnaeus at Jacobsbaai in 2001 – 2002. A relationship between thallus colour and tissue nitrogen, as well as a transition between green-yellows and yellow-browns that occurs between 0.8 – 1.3 mg N per g tissue (Pantone® colours 460U – 455U) for Gracilaria were found, with the green-yellow colour indicating nitrogen-starved material and the yellow-browns indicating nitrogen-replete material. For Ulva a transition between green and yellow-green occurred at a tissue nitrogen content of between 1.5 – 1.7 mg N per g tissue (Pantone® colours 585U and 583U). This relationship can be used by seaweed farmers for cultivation management as a quick guide to determine nutritional status of the seaweeds, and as an indication of protein content when the seaweeds are used as feeds.Web of Scienc

Human immunodeficiency virus type-1 episomal cDNA in semen

BACKGROUND: Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor cryptic HIV-1 infection in the genital tract of men on antiretroviral therapy (ART) to predict the evolution of sexually transmissible drug-resistant HIV-1, but studies thus far have failed to detect this marker in semen. The objectives of this study were: 1) to use a technique that maximizes DNA recovery from HIV-1 infected white blood cells in semen to determine if episomal 2-LTR cDNA is detectable in semen of ART-naïve men with other evidence of genital tract HIV-1 infection, and 2) to compare levels of HIV-1 2-LTR cDNA, RNA, and proviral DNA in semen from HIV-1+ men on ART. RESULTS: Using a somatic cell DNA extraction technique, 2-LTR cDNA was detected by PCR/ELISA in 4 out of 8 semen samples from ART-naïve men selected for other signs of seminal HIV-1 infection (positive controls). Southern blot and DNA sequencing confirmed that the amplified sequences were HIV-1 2-LTR cDNA; copy numbers ranged from 55 to 504 copies/sample. Two semen samples from a cohort of 22 HIV-1-infected men on dual nucleoside therapy, one with and one without detectable seminal HIV-1 RNA, were 2-LTR cDNA positive (336 and 8,560 copies/sample). Following addition of indinavir to the therapy regimen, no semen samples from 21 men with controlled peripheral and seminal viral loads were 2-LTR cDNA positive at 1 and 6 month time points, despite the persistence of HIV-1 proviral DNA+ semen cells and seminal cytomegalovirus (CMV) shedding in some cases. However, one individual who failed indinavir therapy and later developed distinct protease inhibitor (PI) drug resistance mutations in semen, maintained elevated levels of HIV-1 RNA and 2-LTR cDNA in semen. CONCLUSION: 2-LTR HIV-1 cDNA is detectable in semen of HIV-1-infected men. Two men on ART had 2-LTR HIV-1 cDNA in semen, suggesting that this marker may prove to be useful to monitor HIV-1 infection in the genital tract of men on ART to predict the evolution of drug resistance mutations in semen

South African seaweed aquaculture: A sustainable development example for other African coastal countries

The green seaweed Ulva is one of South Africa's most important aquaculture products, constituting an important feed source particularly for abalone (Haliotis midae L.), and utilized as a bioremediation tool and other benefits such as biomass for biofuel production and for integrated aquaculture. Besides Ulva spp, Gracilaria spp. are also cultivated. Wild seaweed harvest in South Africa totals 7,602 mt, compared to 2,015 mt of cultivated Ulva. To mitigate for the reliance on wild harvesting, the South African seaweed aquaculture industry has grown rapidly over the past few decades. On-land integrated culture units, with paddle-wheel raceways, are now widely viewed as the preferred method of production for the industry. The success of seaweed aquaculture in South Africa is due to a number of natural and human (industrial) factors. The development of the seaweed aquaculture industry has paralleled the growth of the abalone industry, and has been successful largely because of bilateral technology transfer and innovation between commercial abalone farms and research institutions. In South Africa seaweeds have been used commercially as feedstock for phycocolloid production, for the production of abalone feed, and the production of Kelpak and Afrikelp, which are plant-growth stimulants used in the agricultural sector. Additionally, Ulva is being investigated for large-scale biogas production. The South African seaweed industry provides a template that could be used by other coastal African nations to further their undeveloped aquaculture potential