A multi-scale model for diffusion of large molecules in steam-exploded wood

In this paper, multi-scale modeling was used to resolve diffusion in steam-exploded wood at tracheid scales including sub-micrometer features of bordered pits. Simulations were performed using the lattice Boltzmann method with high-resolution X-ray tomography image data as the input for the microstructure. The results show an effective method for utilizing a variable diffusion coefficient to implement two length scales. This circumvents the need to resolve the bordered pits in detail, which requires massive computing power. Instead, the effective diffusion coefficient for one bordered pit is used as input for this model. Results based on the present model are comparable to experimental data. This methodology can be extended to more structural features at the microscale of wood, such as latewood and the cell wall. Obtaining a map of different diffusion coefficients based on features and scale gives a better overall understanding of diffusion and the importance of mass transport with regard to the pretreatment of wood

The role of fine excipient particles in adhesive mixtures for inhalation

Despite the fact that adding fines improve the drug dispersion performance during inhalation, the scarcity of mechanistic insight into the formulation process, independent of the aerosolization, has kept the dispute on the underlying improvement mechanism open. We therefore simulate ternary formulations (carrier, drug, fines) in a vibrational cell to explore the mixing mechanism and the effect of particle size and loading ratio of fines on formulation performance. Results suggest that the buffer theory is a critical contributory mechanism since it curtails the carrier\u27s collision rate and, therefore, decreases agglomerate breakage. Consequently, relatively larger drug aggregates are formed over the carrier, which eventually experiences greater detachment forces. A simple dispersion test is performed to evaluate drug detachment rate at wall-collision. An excess of cohesive fines, or using larger fines, diminishes the rotational kinetic energy of coarse particles by lumping them together. This reduces drug agglomerate breakage and leads to poor mixing

Lattice Boltzmann simulations of diffusion in steam-exploded wood

Diffusion of large molecules throughout the porous microstructure of wood pretreated with steam explosion was investigated by using the lattice Boltzmann method for simulations. Wood samples were investigated with high-resolution X-ray tomography to effectively reconstruct an accurate geometry of the structural changes that ensue after pretreatment. Samples of approximately 1\ua0mm3 with voxel sizes from 0.5 to 1\ua0μm were examined with X-ray imaging. These large volumes, relative to what reasonably can be simulated, were divided into sub-volumes and were further reconstructed into geometries suited for the LBM simulations. The transient development of the concentration was investigated, and the effective diffusion coefficient at steady state was computed. Diffusion rates were found to increase significantly in the transversal direction due to the steam explosion pretreatment. The increase was observed both in the time needed for solutes to diffuse throughout the pores and in the effective diffusion coefficient. A shorter diffusion pathway and a higher connectivity between pores were found for the pretreated samples, even though the porosity was similar and the pore size distribution narrower than the native sample. These results show that local mass transport depends not only on porosity but also, in a complex manner, on pore structure. Thus, a more detailed analysis of pore space structure using tomography data, in combination with simulations, enables a more general understanding of the diffusional process

Angle of repose of snow: An experimental study on cohesive properties

The angle of repose is a measure reflecting the internal friction and cohesion properties of a granular material. In this paper, we present an experimental setup and measurements for the angle of repose of snow for seven different snow samples over a large range of temperatures. The results show that the angle of repose is dependent on the fall height, the temperature, and the grain size of the snow. These variables are quantified, and their interdependencies are separately studied. With increased snow temperature, the angle of repose increases, and this can be explained by the presence of a liquid layer on ice that can be thermodynamically stable at temperatures below the melting point of water. With decreasing grain size the angle of repose also increases which is expected since the cohesive energy decreases more slowly than the grain mass. For increasing fall height, the snow grains generally accelerate to larger collisional velocities, yielding a smaller angle of repose. In general, the dimensionless cohesion number was found to largely reflect the dependencies of the variables and is therefore useful for understanding what affects the angle of repose. The results demonstrate that the drag force and collision dynamics of ice grains are important for understanding how snow accumulates on a surface, for example if one desires predicting snow accretion by simulating a dispersed cloud of snow

Collisional damping of spherical ice particles

This paper presents experimental values for the coefficient of restitution (en) for millimeter-sized ice particles colliding with massive walls at different temperatures. Three different wall materials are tested: hardened glass, ice and Acrylonitrile butadiene styrene (ABS) polymer. The results show a high sensitivity to impact velocity Vi, where en decreases rapidly with increasing Vi. The results also show a decrease in en with increasing temperature T. A novel model that predicts en based on the assumption of collisional melting and viscous damping caused by an increased premelted liquid-layer, is proposed. The model predicts both the velocity and the temperature trends seen in the experiments. The difference obtained in experiments between wall materials is also captured by the new model. A generalized regime map for ice particle collisions is proposed to combine the new model with previous work

Global monitoring of fluidized-bed processes by means of microwave cavity resonances

We present an electromagnetic measurement system for monitoring of the effective permittivity in closed metal vessels, which are commonly used in the process industry. The measurement system exploits the process vessel as a microwave cavity resonator and the relative change in its complex resonance frequencies is related to the complex effective permittivity inside the vessel. Also, thermal expansion of the process vessel is taken into account and we compensate for its influence on the resonance frequencies by means of a priori information derived from a set of temperature measurements. The sensitivities, that relate the process state to the measured resonance frequencies, are computed by means of a detailed finite element model. The usefulness of the proposed measurement system is successfully demonstrated for a pharmaceutical fluidized-bed process, where the water and solid contents inside the process vessel is of interest