Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Scarabaeus sp.

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects

Crystal structures of 10 spiro-derivatives of 1,3-thiazine were determined by X-ray diffraction technique. Molecular conformational states, packing architecture, and hydrogen bond networks were studied using graph set notations. Selected compounds were grouped within two classes with chains and dimer crystal structure organization. The sublimation thermodynamic aspects of the spiro-derivatives of 1,3-thiazine were investigated via temperature dependence of vapor pressure using the transpiration method. Thermophysical study of fusion processes of the molecular crystals was carried out and relationships between thermodynamic characteristics of sublimation (fusion) processes and crystal structure parameters were obtained. The influence of various molecular fragments on packing crystal energy was analyzed

Salicylamide Cocrystals: Screening, Crystal Structure, Sublimation Thermodynamics, Dissolution, and Solid-State DFT Calculations

A new cocrystal of 2-hydroxybenzamide (A) with 4-acetamidobenzoic acid (B) has been obtained by the DSC screening method. Thermophysical analysis of the aggregate [A:B] has been conducted and a fusion diagram has been plotted. Cocrystal formation from melts was studied by using thermomicroscopy. A cocrystal single-crystal was grown and its crystal structure was determined. The pattern of noncovalent interactions has been quantified using the solid-state DFT computations coupled with the Bader analysis of the periodic electron density. The sublimation processes of A-B cocrystal have been studied and its thermodynamic functions have been calculated. The classical method of substance transfer by inert gas-carrier was chosen to investigate sublimation processes experimentally. The lattice energy is found to be 143 ± 4 kJ/mol. It is lower than the sum of the corresponding values of the cocrystal pure components. The theoretical value of the lattice energy, 156 kJ/mol, is in reasonable agreement with the experimental one. A ternary phase diagram of solubility (A-B–ethanol) has been plotted and the areas with solutions for growing thermodynamically stable cocrystals have been determined