66 research outputs found
The electrophotonic silicon biosensor
The emergence of personalized and stratified medicine requires label-free and low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high sensitivity analysis with scalable, low-cost manufacturing technology but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here, we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomolecules. Our electro-photonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical processes enables site selective immobilization of different biomolecules, here single stranded DNA, onto individual microrings within a sensor array. The combination of photonic and electrochemical characterization of molecules bound to the sensor surface also provides direct quantification of binding density and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for sensing on the micro-scale
Syntheses, optical properties, and bioapplications of the aggregation-induced emission of 2,3,4,5-tetraphenylcyclopenta-2,4-dienyl benzene derivatives
10.1039/c2jm32755dJournal of Materials Chemistry223619303-19310JMAC
Nanoscale Patterning of Flat Carbon Surfaces by Scanning Probe Lithography and Electrochemistry
‘Soft’ Au, Pt and Cu contacts for molecular junctions through surface-diffusion-mediated deposition
Electronic Characteristics and Charge Transport Mechanisms for Large Area Aromatic Molecular Junctions
Selective Immobilization of DNA and Antibody Probes on Electrode Arrays: Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform
Determination of the Structure and Orientation of Organic Molecules Tethered to Flat Graphitic Carbon by ATR-FT-IR and Raman Spectroscopy
Charge Transfer between Electroactive Species Immobilized on Carbon Surfaces by Aryl Diazonium Reduction. SECM Investigations
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