Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology

The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 32 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X1) and stirring speed (X2), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release

Supplemental data for "<b>Serum Chemerin levels correlate with the severity of dysglycemia in young adult women with polycystic ovary syndrome</b>"

· High serum chemerin levels are seen in dysglycemic PCOS alone, not in all PCOS· Serum Chemerin correlated positively with Body fat (%), not waist girth or BMI· Serum Chemerin correlated positively with HOMA-IR and negatively with HOMA-2β· Chemerin >309.3 ng/ml clearly differentiated PCOS with T2D from those without· A substantial agreement existed between the Chemerin cut off and 2hPGPG>200 mg/dL</p

High spin states of 37Ar^{37}\mathrm{Ar}

International audienceHigh spin states of Ar37, populated through the Al27(C12,np)Ar37 reaction with a 40 MeV C12 beam, were studied using the Indian National Gamma Array (INGA) facility. The existing level scheme has been extended up to 10.5 MeV by adding some new levels and transitions. The spins and parities of the new levels were assigned from RDCO, RADO, and linear polarization measurements. The spins and parities of the existing levels also were modified or confirmed in the present experiment. The multipole mixing ratios (δ) for most of the transitions were measured and compared with the earlier measurements wherever available. Large basis shell model calculations with different particle restrictions in sd and pf orbitals were performed to understand the microscopic origin of these levels. A simple two-level mixing calculation was also performed to extract the amount of multiparticle multihole configuration mixing for a few levels