Management and perinatal outcomes of hypertensive disorders of pregnancy in a low-resource setting in Indonesia

Objectives: To provide up-to-date data concerning hypertensive disorders of pregnancy on maternal and neonatal profiles in Indonesia. Methods: Retrospective clinical audit on all pregnancy-associated hypertensive women between 1 January 2020 and 31 March 2020 at Cianjur General District Hospital. Results: Preeclampsia accounts for 66.8% (235/352) of hypertensive disorders of pregnancy, gestational hypertension 29% (102/352) and chronic hypertension 4.3% (15/352). Compared to other pregnant women, those with preeclampsia, on average, had higher systolic and diastolic blood pressures and poorer kidney (ureum and creatinine) and liver function (aspartate transaminase enzyme and alanine transaminase enzyme) profiles (p < 0.001, < 0.001, < 0.001, 0.003, 0.033 and 0.002, respectively), and required more intensive care admission. Neonates from women with severe forms of preeclampsia (eclampsia and HELLP syndrome (haemolysis, elevated liver enzymes, low platelets)) had, on average, lower birthweight (p = 0.015 and 0.048, respectively) and birth length (p = 0.021, 0.017). Neonates from eclamptic mothers had poorer APGAR (appearance, pulse, grimace, activity and respiration) scores (p = 0.006 and 0.005, respectively). Conclusion: Hypertensive disorders of pregnancy exerts adverse maternal and neonatal outcomes, particularly among eclampsia and HELLP-syndrome neonates. Various challenges remain for optimal management

Analysis and Modeling of Human Body When Exposed to Automotive Vehicle

Vibration is one of the important considerations in design. Nowadays, almost every family has the car. So, it becomes most important to study the vehicle vibrations. Analysis of human body physical model experimentally when situated in automotive vehicle. The model fabrication is done on the basis of comparing real human body parameters with human physical models used in the ISO 10068:2012 standard. This article revealed effect of vibration transferring to the specific parts of human body due to vibration transferring from Seat to Height (STH) and from Hands on steering. The focus of the present study was to determine the vibration output from fabricated model. The vibrations as input to the model are from automotive vehicles. The input verses output vibration characteristics will be useful to study effects of vibration on human health. The human body is considered as a simple spring, mass, damper system for analysis. This multi body model representative of the automotive postures found in the literature were investigated, one with and the other without a backrest support. The model was modified to suitably represent the different automotive postures with and without backrest supports, and validated by various experimental data from the published literature pertaining to the same postural conditions on the basis of the analytical study and the experimental

New Clathrin-Based Nanoplatforms for Magnetic Resonance Imaging

Background: Magnetic Resonance Imaging (MRI) has high spatial resolution, but low sensitivity for visualization of molecular targets in the central nervous system (CNS). Our goal was to develop a new MRI method with the potential for non-invasive molecular brain imaging. We herein introduce new bio-nanotechnology approaches for designing CNS contrast media based on the ubiquitous clathrin cell protein. Methodology/Principal Findings: The first approach utilizes three-legged clathrin triskelia modified to carry 81 gadolinium chelates. The second approach uses clathrin cages self-assembled from triskelia and designed to carry 432 gadolinium chelates. Clathrin triskelia and cages were characterized by size, structure, protein concentration, and chelate and gadolinium contents. Relaxivity was evaluated at 0.47 T. A series of studies were conducted to ascertain whether fluorescent-tagged clathrin nanoplatforms could cross the blood brain barriers (BBB) unaided following intranasal, intravenous, and intraperitoneal routes of administration. Clathrin nanoparticles can be constituted as triskelia (18.5 nm in size), and as cages assembled from them (55 nm). The mean chelate: clathrin heavy chain molar ratio was 27.0464.8: 1 fo

The relationship between geology and rock weathering on the rock instability along Mugling-Narayanghat road corridor, Central Nepal Himalaya

The present study was conducted along the Mugling–Narayanghat road section and its surrounding region that is most affected by landslide and related mass-movement phenomena. The main rock types in the study area are limestone, dolomite, slate, phyllite, quartzite and amphibolites of Lesser Himalaya, sandstone, mudstone and conglomerates of Siwaliks and Holocene Deposits. Due to the important role of geology and rock weathering in the instabilities, an attempt has been made to understand the relationship between these phenomena. Consequently, landslides of the road section and its surrounding region have been assessed using remote sensing, Geographical information systems and multiple field visits. A landslide inventory map was prepared and comprising 275 landslides. Nine landslides representing the whole area were selected for detailed studies. Field surveys, integrated with laboratory tests, were used as the main criteria for determining the weathering zones in the landslide area. From the overall study, it is seen that large and complex landslides are related to deep rock weathering followed by the intervention of geological structures as faults, joints and fractures. Rotational types of landslides are observed in highly weathered rocks, where the dip direction of the foliation plane together with the rock weathering plays a principle role. Shallow landslides are developed in the slope covered by residual soil or colluviums. The rock is rather fresh below these covers. Some shallow landslides (rock topples) are related to the attitude of the foliation plane and are generally observed in fresh rocks. Debris slides and debris flows occur in colluviums or residual soil-covered slopes. In few instances, they are also related to the rock fall occurring at higher slopes. The materials from the rock fall are mixed with the colluviums and other materials lying on the slope downhill and flow as debris flow. Rock falls are mainly related to the joint pattern and the slope angle. They are found in less-weathered rocks. From all these, it is concluded that the rock weathering followed by geological structures has prominent role in the rock slope instability along Mugling–Narayanghat road section and its surrounding regions