Hospitalization at home: a study of international models and adaptation to the portuguese context

Hospitalization at Home (HaH) has proved to be an efficient and effective model of healthcare provision in several countries in the World. Portugal is starting the implementation of this model based on international best-practices. This paper describes themain features of this HaH service, their organizational, technological and economic enablers –with a sustainability perspective. It then presents their application in recognized role-model countries –the UK, Australia, and Spain. Finally, it outlines the current implementation plan being carried out by the Portuguese Public National Healthcare Service and aims to identify opportunities for improvements in such implementation

Flying under the radar - impact and factors influencing asymptomatic DENV infections

The clinical outcome of DENV and other Flaviviruses infections represents a spectrum of severity that ranges from mild manifestations to severe disease, which can ultimately lead to death. Nonetheless, most of these infections result in an asymptomatic outcome that may play an important role in the persistent circulation of these viruses. Also, although little is known about the mechanisms that lead to these asymptomatic infections, they are likely the result of a complex interplay between viral and host factors. Specific characteristics of the infecting viral strain, such as its replicating efficiency, coupled with host factors, like gene expression of key molecules involved in the immune response or in the protection against disease, are among crucial factors to study. This review revisits recent data on factors that may contribute to the asymptomatic outcome of the world's widespread DENV, highlighting the importance of silent infections in the transmission of this pathogen and the immune status of the host.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by FCT-Fundação para a Ciência e a Tecnologia (Project ref.PTDC/SAU-INF/30440/2017). Paulo Henriques was suported by ARDITI (Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação) through a PhD Grant (M1420-09-5369-FSE-000001)

Flying under the radar – impact and factors influencing asymptomatic DENV infections

The clinical outcome of DENV and other Flaviviruses infections represents a spectrum of severity that ranges from mild manifestations to severe disease, which can ultimately lead to death. Nonetheless, most of these infections result in an asymptomatic outcome that may play an important role in the persistent circulation of these viruses. Also, although little is known about the mechanisms that lead to these asymptomatic infections, they are likely the result of a complex interplay between viral and host factors. Specific characteristics of the infecting viral strain, such as its replicating efficiency, coupled with host factors, like gene expression of key molecules involved in the immune response or in the protection against disease, are among crucial factors to study. This review revisits recent data on factors that may contribute to the asymptomatic outcome of the world’s widespread DENV, highlighting the importance of silent infections in the transmission of this pathogen and the immune status of the host

Regulatory CD4+ CD25+ Foxp3+ T cells expand during experimental Plasmodium infection but do not prevent cerebral malaria.

International audiencePathogenic CD8+ T cells are implicated in the physiopathological mechanisms leading to experimental cerebral malaria (CM) in Plasmodium berghei ANKA (PbA) infected mice. Therefore, we hypothesised that in CM susceptible mice the neuropathology could be, at least in part, the result of an inefficient control of pathogenic effector T cells by CD4+ CD25+ Treg cells. Remarkably, the number of CD4+ CD25high T cells expressing Foxp3 increased in the spleen during the course of infection. These cells displayed an activated phenotype and consistent with that, CD4+ CD25high Treg cells isolated from PbA-infected mice showed an enhanced regulatory activity in vitro. Surprisingly, these cells do not migrate to the brain at the time of neurological symptoms as the conventional CD4+ T cells do. CM was not exacerbated in anti-CD25 treated mice when infected with PbA one month after treatment, even if splenic CD8+ T cells expressing CD69 increased in these mice. Taken together, these results show that P. berghei infection leads to an increase of the number of splenic CD4+ CD25high Treg cells exhibiting in vitro suppressive function, but they do not seem to be involved in vivo in the protection against CM

Linguística clínica: Modelos, avaliação e intervenção

SinopseA Linguística Clínica reúne profissionais, investigadores e estudantes de diferentes graus académicos cujo foco de trabalho é a exploração da ponte entre a Linguística e a Fonoaudiologia (na tradição brasileira) ou a Terapia da Fala (na tradição portuguesa). Tem como objetivos centrais a construção de conhecimento sobre a natureza dos desempenhos linguísticos atípicos e a preocupação constante em tornar os processos de avaliação e de intervenção em contexto clínico cada vez mais rigorosos e eficazes. O presente volume destina-se a quem estuda ou investiga aspetos relacionados com desempenhos linguísticos atípicos em países lusófonos, nomeadamente a estudantes e docentes de cursos de graduação e pós-graduação nas áreas da Terapia da Fala/ Fonoaudiologia, da Linguística, da Psicologia e da Educação. Os capítulos que integram a presente publicação estão organizados em quatro blocos temáticos. O bloco inicial tem como objetivo central fornecer uma perspetiva histórica dos estudos em Fonologia Clínica e em Sintaxe Clínica. O segundo centra-se em aspetos fonológicos e sua relação com a dimensão fonética da língua. O terceiro bloco integra capítulos que exploram o módulo gramatical da sintaxe, a interface gramática-pragmática e o discurso. O último bloco reúne um conjunto de investigações sobre populações específicas. Synopsis Clinical Linguistics brings together professionals, researchers and students in different academic degrees focused on the bridge between Linguistics and Speech and Language Therapy. The main purpose is to display knowledge on the nature of atypical linguistic performances and to make the assessment and intervention processes increasingly rigorous and effective in the clinical context.This volume is intended for those who study or investigate aspects related to atypical linguistic performance in Portuguese-speaking countries, namely for students and teachers of undergraduate and postgraduate courses in the areas of Speech and Language Therapy, Linguistics, Psychology and Education. The chapters that make up this publication are organized into four thematic blocks. The main objective of the initial block is to provide a historical perspective of studies in Clinical Phonology and Clinical Syntax. The second block focuses on phonological aspects and their relationship with the phonetic dimension of the language. The third one includes chapters that explore the grammatical module of syntax, the grammar-pragmatic interface and discourse. The last block brings together a set of investigations on specific populations

Linguística clínica: Modelos, avaliação e intervenção

SinopseA Linguística Clínica reúne profissionais, investigadores e estudantes de diferentes graus académicos cujo foco de trabalho é a exploração da ponte entre a Linguística e a Fonoaudiologia (na tradição brasileira) ou a Terapia da Fala (na tradição portuguesa). Tem como objetivos centrais a construção de conhecimento sobre a natureza dos desempenhos linguísticos atípicos e a preocupação constante em tornar os processos de avaliação e de intervenção em contexto clínico cada vez mais rigorosos e eficazes. O presente volume destina-se a quem estuda ou investiga aspetos relacionados com desempenhos linguísticos atípicos em países lusófonos, nomeadamente a estudantes e docentes de cursos de graduação e pós-graduação nas áreas da Terapia da Fala/ Fonoaudiologia, da Linguística, da Psicologia e da Educação. Os capítulos que integram a presente publicação estão organizados em quatro blocos temáticos. O bloco inicial tem como objetivo central fornecer uma perspetiva histórica dos estudos em Fonologia Clínica e em Sintaxe Clínica. O segundo centra-se em aspetos fonológicos e sua relação com a dimensão fonética da língua. O terceiro bloco integra capítulos que exploram o módulo gramatical da sintaxe, a interface gramática-pragmática e o discurso. O último bloco reúne um conjunto de investigações sobre populações específicas. Synopsis Clinical Linguistics brings together professionals, researchers and students in different academic degrees focused on the bridge between Linguistics and Speech and Language Therapy. The main purpose is to display knowledge on the nature of atypical linguistic performances and to make the assessment and intervention processes increasingly rigorous and effective in the clinical context.This volume is intended for those who study or investigate aspects related to atypical linguistic performance in Portuguese-speaking countries, namely for students and teachers of undergraduate and postgraduate courses in the areas of Speech and Language Therapy, Linguistics, Psychology and Education. The chapters that make up this publication are organized into four thematic blocks. The main objective of the initial block is to provide a historical perspective of studies in Clinical Phonology and Clinical Syntax. The second block focuses on phonological aspects and their relationship with the phonetic dimension of the language. The third one includes chapters that explore the grammatical module of syntax, the grammar-pragmatic interface and discourse. The last block brings together a set of investigations on specific populations