17 research outputs found
Vaccination Coverage and Compliance with Three Recommended Schedules of 10-Valent Pneumococcal Conjugate Vaccine during the First Year of Its Introduction in Brazil: A Cross-Sectional Study
<div><p>Pneumococcal 10-valent conjugate vaccine (PCV10) was introduced to Brazil’s National Immunization Program (NIP) in 2010. During the first year of vaccine introduction three schedules were used to deal with age at initiation of PCV for catch-up purposes: 3 primary doses + 1 booster (for children aged ≤6 months), a catch-up schedule of 2 doses + 1 booster (7-11 months), and a catch-up schedule of a single dose (12-15 months). The purpose of this study was to assess the magnitude and associated risk factors for under-vaccination or lack of on time vaccination six to eight months after PCV10 introduction. A household survey was conducted in the municipality of Goiania with 1,237 children, who were retroactively classified into one of three age groups, as a factor of the child’s age relatively to 30 days after PCV10 introduction. Socioeconomic characteristics and vaccination dates were obtained during home interviews. Vaccination coverage was defined as the percentage of children who completed the recommended number of doses. Compliance with recommended schedules was defined as the percentage of children who received all valid doses at the NIP recommended time interval. Adjusted prevalence ratios (PR) of variables independently associated with coverage and compliance were estimated by log binomial regression. Coverage of DTP-Hib was used for comparison purposes. Overall, vaccination coverage was 54.6% (95% CI 52.1-57.7%), lower than DTP-Hib coverage (93.0%; 95% CI 91.5-94.3%). Compliance with recommended schedules was 16.8% (95% CI: 14.7-18.6%). Children 7-11 months old had lower coverage (40.7%) and compliance (6.3%) compared to children aged 12-15 months (coverage: 88.8%; compliance: 35.6%) and ≤6 months old (coverage: 54%; compliance: 18.8%). Having private health insurance was associated with higher PCV10 coverage (PR=1.25; 95% CI: 1.06-1.47, p=0.007), and compliance (PR=1.09; 95% CI: 1.02-1.16, p=0.015). Although PCV10 coverage rapidly increased shortly after vaccination introduction, it was not matched by compliance with recommended schedules. Public initiatives should target compliance of PCV10 because of the burden of pneumococcal diseases on childhood morbidity and mortality.</p></div
Variables associated with PCV10 coverage, 6 to 8 months after its introduction.
<p>Goiania, December 2010 to February 2011.</p><p>PR: prevalence ratio; adj PR: adjusted prevalence ratio.</p><p>* The sum of individuals is not always 1,237 because there are missing answers, but that represents less than 8% of all participants.</p><p>Variables associated with PCV10 coverage, 6 to 8 months after its introduction.</p
Kaplan-Meier curves of incidence for the first dose of PCV10 after its introduction in the routine immunization program.
<p>Goiania, December 2010 to February 2011.</p
Population, case-counts and rates for all-cause OM outpatient visits and all-other causes in children aged 2 to 23 months.
<p>Goiânia, Brazil, August 2008-July 2015.</p
Predicted and observed monthly rates for all-cause OM and for all-other causes for children aged 2 to 23 months in the post-vaccination period.
<p>Interrupted time-series analysis. Goiânia, August 2011-July 2015.</p
Reduction in all-cause otitis media-related outpatient visits in children after PCV10 introduction in Brazil - Fig 1
<p>Trends in observed (black lines) and predicted (gray lines) OM (Panel A), and all-cause otitis (Panel B) outpatient visits monthly rates per 100,000 children. Dashed gray lines represent the 95%CI for the predicted rates in the post-vaccination period. The gray bar represents the transition period (August 2010 to July 2011), which was excluded from the time-series analysis.</p
Annual relative percentage change on pneumonia hospitalizations by age-group in the post-vaccination period.
<p>Brazil, 2011–2015.</p
Average annual pneumonia rates (per 100,000 population) of pneumonia hospitalizations in the pre- and post-PCV10 vaccination periods, by age-groups. Brazil, 2005–2015.
<p>Average annual pneumonia rates (per 100,000 population) of pneumonia hospitalizations in the pre- and post-PCV10 vaccination periods, by age-groups. Brazil, 2005–2015.</p
Percentage change in rates for pneumonia hospitalization and comparison groups, and relative percentage change (PCV10 impact) with respective confidence intervals, by age-group.
<p>Brazil, 2011–2015.</p
Annual rates (per 100,000 population) of pneumonia and comparison group hospitalizations, by age-group. Brazil, 2005–2015.
<p>Annual rates (per 100,000 population) of pneumonia and comparison group hospitalizations, by age-group. Brazil, 2005–2015.</p