Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate

Helminth parasites induce Th2 immune responses. Immunological mechanisms leading to Th2 induction are mainly dependent on IL-4. However, early source of IL-4 has not been precisely identified. Noticeably, basophils seem to be important mediators for inducing and maintaining the Th2 response probably because they secrete IL-4 and exert functions similar to APCs. Nevertheless, recent experimental evidence points that DCs could be also significant participants during this process. The involvement of basophils during memory responses is also discussed

Microalgae growth in different trophic conditions

Microalgae growth in different trophic conditions ( Poster Presentation) in Abstract Book 5th Algaeurope Conferenceinfo:eu-repo/semantics/publishedVersio

Depresión y adherencia al tratamiento farmacológico en pacientes con diabetes mellitus 2, del Hospital II Reategui

Objetivo: la relación entre la depresión y la adherencia al tratamiento farmacológico de personas con diabetes mellitus tipo 2 del Hospital II Jorge Reátegui Delgado-Piura, 2019. Metodología: la investigación es básica, observacional de tipo analítico transversal con toma de datos primarios. Se tuvo como muestra a 228 pacientesdiagnosticados con DM2 que, luego de cumplir los criterios de selección de inclusión y de exclusión, pudieron ser clasificados de modo adecuado. La recolección de información se realizó mediante la aplicación de un instrumento de investigación (ficha de datos) y el inventario de depresión de Beck. Resultados: de los 228 pacientes, el 84.6% están deprimidos y solo el 15,4% no presentan depresión. El nivel de depresión que se encuentra con más frecuencia en los pacientes es la depresión grave con un 39.2% de la totalidad de los pacientes, seguido de pacientes con depresión moderada, los cuales representan el 19.4% de los pacientes, y continuando con Pacientes con depresión extrema con un 13.2% y finalmente tenemos el 12.8% del total de los pacientes con Depresión Leve.Con respecto al control de la Glucemia Basal, el análisis multivariado mostró que los pacientes que tienen un mal control de la misma, tiene más riesgo de tener depresión que los pacientes con un buen control de la Glucemia Basal, lo mismo sucede con respecto al control de la Hemoglobina Glucosilada, los pacientes con un mal control de la misma, son más propensos a tener un tipo de depresión. Al tener en cuenta el estado ocupacional el análisis demostró que los pacientes que no se encuentran laborando son los más propensos a presentar depresión, de igual manera sucede con los pacientes del sexo masculino, los pacientes que tienen problemas con su masa corporal (peso), los pacientes que se encuentran sin una pareja sentimental y las personas que tienen un edad inferior a 50 años. Conclusiones: Se encontró relación entre la depresión y la adherencia al tratamiento farmacológico de los pacientes con diabetes mellitus tipo 2 del Hospital II Jorge Reátegui Delgado.Objective: the relationship between depression and adherence to pharmacological treatment of people with type 2 diabetes mellitus of Hospital II Jorge Reátegui Delgado-Piura, 2019. Methodology: the research is basic, observational, cross-sectional analytical type with primary data collection. A sample of 228 patients diagnosed with DM2 was taken, which, after meeting the inclusion and exclusion selection criteria, could be properly classified. Information was collected through the application of a research instrument (data sheet) and Beck's depression inventory. Results: of the 228 patients, 84.6% are depressed and only 15.4% do not have depression. The level of depression most frequently found in patients is severe depression with 39.2% of all patients, followed by patients with moderate depression, who represent 19.4% of patients, and continuing with patients with extreme depression with 13.2% and finally we have 12.8% of the total of patients with Mild Depression. Regarding the control of Basal Glycemia, the multivariate analysis showed that patients who have poor control of it, have a higher risk of having depression than patients with good control of Basal Glycemia, the same happens with respect to control. of glycated hemoglobin, patients with poor control of it, are more likely to have a type of depression. Taking into account the occupational status, the analysis showed that patients who are not working are the most likely to have depression, as is the case with male patients, patients who have problems with their body mass (weight), patients who are without a romantic partner and people who are under 50 years of age. Conclusions: A relationship was found between depression and adherence to drug treatment of patients with type 2 diabetes mellitus of Hospital Jorge Reátegui Delgado II.Tesi

Engineering of specific bacteriophages for early diagnosis of Alzheimer′s disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting a large proportion of the human population worldwide with great impact on social and economic level. At molecular level, AD is characterized by an increased deposition of plaques, which consist of amyloid-beta however, it is not the amyloid-beta in plaques, but amyloid-beta in soluble oligomeric form that impairs synaptic function and memory encoding. The limitations imposed by the blood-brain barrier (BBB) have hindered the development of new diagnostic/therapeutic techniques. Also, AD-treatments that target plaques have proven to be ineffective, therefore it is important to find diagnostic and therapeutic tools that selectively target amyloid-beta in oligomeric form. Peptie ligands that selectively recognize AB-oligomers are available, however they are not able to cross the BBB. To overcome this limitation, the development and application of viruses has become a very interesting tool. Bacteriophages (or phages – virus that only infect bacterial cells) can bypass the BBB and can be genetically and chemically manipulated in order to recognize and target specific biomarkers commonly used for AD diagnostic. The present work describes the development of a bacteriophage-based system that can be capable of diagnose AD at an early stage by shuttling amyloid-beta specific ligands across the BBB. Phages were genetically engineered with two peptide sequences described to selectively recognize amyloid-beta oligomers in order to target and visualize amyloid-beta aggregates in the brain. Future work will be devoted to test this system in AD-mouse models for diagnosis purposes at an early stage of the disease. If successful, this approach will provide the neuroscience community with a promising tool for AD early diagnose

Marital Processes and Parental Socialization in Families of Color: A Decade Review of Research

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73804/1/j.1741-3737.2000.01070.x.pd

A Reference Meta-model to Understand DNA Variant Interpretation Guidelines

Determining the role of a DNA variant in patients’ health status – a process known as variant interpretation – is highly critical for precision medicine applications. Variant interpretation involves a complex process where, regrettably, there is still debate on how to combine and weigh diverse available evidence to achieve proper and consistent answers. Indeed, at the time of writing, 22 different variant interpretation guidelines are available to the scientific community, each of them attempting to establish a framework for standardizing the interpretation process. However, these guidelines are qualitative and vague by nature, which hinders their streamlined application and potential automation. Consequently, more precise definitions are needed. Conceptual modeling provides the means to bring clarification within this domain. This paper presents our efforts to define and use a UML meta-model that describes the main concepts involved in the definition of variant interpretation guidelines and the constructs they evaluate. The precise conceptual definition of the guidelines allowed us to identify four common misinterpretation patterns that hamper the correct interpretation process and that can consequently affect classification results. In several proposed examples, the use of the meta-model provides support in identifying the inconsistencies in the observed process; this result paves the way for further proposing reconciliation strategies for the existing guidelines

Redes sociales y su incidencia en la decisión de compra de los clientes de un restaurante en Piura, 2022

El presente estudio buscó determinar la incidencia de las Redes sociales en la decisión de compra de los clientes de un restaurante en Piura en el año 2022, la investigación tiene un enfoque cuantitativo, de tipo aplicada, su diseño es no experimental correlacional, presentando una población infinita por lo que se trabajó con una muestra de 404 clientes, empleando la encuesta como técnica y dos cuestionarios como instrumentos, de 13 y 15 preguntas respectivamente, se midió la relación entre las variables a través del coeficiente de Spearman, evidenciando un P-valor =0.000 inferior a 0.01, lo que denota un alto grado de significancia rechazando tajantemente la hipótesis nula, la relación entre variables es de 0.549, lo cual indica que en la medida que mejora el uso de las redes sociales, mejora la decisión de compra en todos sus aspectos, concluyendo que las redes sociales ejercen una influencia significativa (Sig.<0.05) en la decisión de compra del cliente, mostrando una incidencia moderada del 30,14% entre ambas variables, de acuerdo al coeficiente de determinación, por lo que el uso de las redes es fundamental para persuadir al cliente en su decisión de compra en el restaurante investigado

El Karaoke como recurso didáctico para mejorar la producción oral del idioma Inglés de los estudiantes del V ciclo de la escuela académico profesional de idiomas de la UNSM Tarapoto - 2013

The present work gives a new alternative in the teaching-learning of the English language with the purpose of improving the oral production of the students of the National University of San Martin - Tarapoto, Professional Academic School of Languages. The research had as a principal objective to develop the oral production of the English language through the methodological proposal Let's Sing and Learn English Together that used as a main strategy the KARAOKE, as an educational resource that was carried out in 8 lesson plans. Each class has 4 stages: Music to my ears, All ears, Face the music and a toast. We could appreciate the achievement of the students in each class making use of observation sheets that were checked and organized correctly. In order to achieve the goals, the methodological proposal Let's Sing and Learn English Together was applied, then a data tabulation, the description and the corresponding analysis were performed, we compared the data obtained before and after performing the proposal, which assessed four components: fluency, coherence, intonation and vocabulary. The results show that the methodological proposal Let's Sing and Learn English Together influenced significantly in the development of oral production in the students of the V cycle of the Professional Academic School of Languages-UNSM. So it is clear that the methodology, content and materials used in the application of the methodological proposal Let's Sing and Learn English Together influenced significantly in the oral production of the English language students of the V cycle of the Professional Academic School of Languages of the National University of San Martin.El presente trabajo de investigación brinda una nueva alternativa en la Enseñanza - Aprendizaje del idioma inglés con el fin de mejorar la producción oral de los estudiantes del V ciclo de la Escuela Académica Profesional de Idiomas de la Universidad Nacional de San Martin - Tarapoto. La investigación tuvo como objetivo principal desarrollar la producción oral del idioma inglés a través de la propuesta metodológica Let's Sing and Learn English Together que usó como estrategia principal al KARAOKE como recurso didáctico, la cual se llevó a cabo en ocho planes de clase. Cada clase contó con cuatro etapas que son: Music to my ears, All ears, Face the music y A toast. Durante cada clase se pudo apreciar el logro de los estudiantes haciendo uso de fichas de observación debidamente organizadas y revisadas. Para cumplir con los objetivos, se aplicó la propuesta metodológica Let's Slng and Learn English Together, luego se realizó la tabulación de datos, la descripción y el análisis correspondiente, se comparó los datos obtenidos antes y después de la aplicación. Se evaluaron cuatro componentes en la producción oral: fluidez, coherencia, entonación y vocabulario. Los resultados muestran que la propuesta metodológica Let's Sing and Learn English Together influyó significativamente en el desarrollo de la producción oral. Por lo que queda demostrado que la metodología, contenidos y materiales utilizados en la ejecución de la propuesta metodológica Let's Sing and Learn English Together influyeron significativamente en la producción oral del idioma inglés de los estudiantes del V ciclo de la EAPI de la Universidad Nacional de san Martin