Young Children’s Use of Mobile Technology: Impacts on Self-Regulation and Aggression

The present study tested the displacement hypothesis, which proposed that mobile technology use disrupts important daily activities and social interactions that are important for the development of young children’s self-regulation skills (Gentile et al., 2012). As a result of this displacement, children are more likely to become dysregulated and aggressive. Participants were 174 caregivers (n = 157 mothers) who reported on their children aged 2 to 5 years old (n = 100 male). All participants completed self-report questionnaires assessing their own technology use, interference in the parent-child relationship due to mobile technology, and the use of mobile technology as a parenting tool. Caregivers also reported on their children’s use of mobile technology, participation in the environment, self-regulation, aggressive behaviour, and temperament. A subset of 15 caregivers (n = 14 mothers) also answered open-ended interview questions about their attitudes, perceptions, and experiences regarding mobile technology use in the family. The analyses revealed that mobile technology use by both caregivers and children negatively impacted young children’s self-regulation and aggressive behaviour. Greater use of mobile technology was found to displace daily activities and social interactions, leading to greater dysregulation and aggression. Results also demonstrated that greater use of mobile technology as parenting tools mediated the relation between greater mobile technology use and children’s aggressive behaviour. A thematic analysis of caregivers’ interviews revealed that caregivers have many strategies to monitor their children’s media activity, concerns about the negative impacts of mobile technology, and tensions about using these devices in the family. The novelty of these findings address gaps in the literature by identifying various ways in which mobile technology can interfere with young children’s daily lives in a way that is detrimental for the development of their self-regulation and aggressive behaviour

Aptamers for in vivo applications

textWhen aptamers emerged almost two decades ago, “selection-ologists” quickly realized the aptamer’s clinical potential - both as a diagnostic tool and as a therapeutic. Since that time, nearly hundreds of medically relevant targets have been successfully selected against. Moreover, many have proven efficacy in tissue culture and animal models. However, only one has successfully advanced to clinical use. Several key limitations in aptamer-based drugs may explain the dearth of aptamers in the pharmacy. Issues of expression level, delivery, and targeting will need to be addressed before aptamers can reach their full clinical potential. This work broaches on aspects of these limitations and leads into ways of transitioning the aptamer into clinical use.Cellular and Molecular Biolog

The Determinants of Customer Perceptions in a Dynamic Business Environment: An Exploratory Analysis of the ASP Business Model

Outsourcing attracted much attention in 1989 when Kodak outsourced its data center operation to IBM (International Business Machines Corp.). Nowadays, this strategy has become more popular. At the beginning of this century, the ASP (Application Service Provider) model was considered one of the typical solutions of Internet-based IT (Information Technology) outsourcing. Although this model has been transformed and renamed (e.g. SaaS - Software as a Service), the principle concept of providing IT service through the Internet or wide area network is still there. This study attempts to explore the determinants of customer perception of Internet-based IT outsourcing by obtaining a comprehensive understanding of the ASP model. The research dimensions not only include factors affecting users' perception of service quality but also ASP business position (i.e. the firm origin of ASP and its provider type) and services utilized by the customers. Through the study of firm history, two important theoretical themes of this research - path-dependence and Ansoff's product/ market growth matrix - are taken account of in exploring the influence of the determinants. Web-based questionnaire survey research is conducted together with a documentation study to collect data. Targeting the customers of the top 50 ASPs selected by ASPnews.com during the period 2001-2004, the researcher contacted 597 potential respondents, and 196 responses were returned. The valid sample consisted of 175 responses, and 124 of them not only provided full information for satisfaction evaluation but also the information for tracking their ASP vendors' business position. The GLM (General Linear Model) and the Pearson correlation coefficient were the major statistical approaches used to evaluate the survey data for developing a structural model. The research findings indicated that the factors associated with service competitiveness, such as capability and performance, reliability and trustworthiness, affordability, integration and customization, have positive effects on customer perceived satisfaction; whereas lock-in has a negative effect. More specifically, the origin of the ASP firm has a direct effect on capacity and performance, and also directly influences the use of IT adoption services. Based on this finding, a descriptive analysis and qualitative research shows that two mechanisms for path-dependence - existing expertise and perceived expertise - can affect the satisfaction level of capacity and performance of ASP services. On the other hand, provider type has a direct effect on affordability and also directly influences the use of facility supporting services. On this basis, another two mechanisms for path-dependence - transaction cost and standardization - can indirectly impact customer's perception of this business model via affordability. In addition to those major findings, some other determinants (e.g. software applications, brand of applications, and intensity of service used) were also identified in this study. The study result can be used for theoretical understanding about the determinants of ASP customer's perception. It not only indicates a new perspective to enhance the current body of research on this topic, but can also be more broadly applied to any fast-growth firm, rapid-change business, or technology intensive industry. Acknowledgements I would like to sincerely thank the following people for their contribution to this research project. Dr. Scott Koslow, my chief supervisor, for his continued encouragement, patience and guidance to ensure the completion of this project. His speciality in statistics has provided appropriate and valuable guidance in the data analysis for my research. Dr. Steven Lim, my second supervisor, for his advice, coherence, and support over the years. I also appreciate his constructive comments on my drafts and the shaping of my research. Dr. Bob McQueen and Dr. Jim Corner, for their assistance and advice in the early stages of my study. My parents, Yu-Ho and Lee-Chiung Liang, and my brother Ken, my sisters Annie, Eva, and Nancy, my brothers-in-law, J.C. and Chen, and Alice, my sister-in-law, for their emotional support throughout the length of my study. I also thank Bessie, my best friend for her assistance in data collection and her loving support, as well as Ted, Kevin, Mark, Frank, and Shirley, my study mates for their encouragement and friendship. Special thanks goes to Dr. Kuang-Ya Wang, the principal of Yu Da High School of Commerce and Home Economics, Taiwan, and also to the staff over there for their concern and assistance in data collection. Most importantly, my heartfelt appreciation goes to Warren, my husband. I am deeply grateful to him for his understanding, patience, and practical help. Without his enduring support I could not have done this study. Finally, my thanks and gratitude goes to those people who patiently answered my survey questionnaire as their kind assistance made it possible to complete this research

Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity.

BackgroundThe study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity despite the relevance of this developmental stage to trajectories of weight gain. We hypothesized that salivary DNA methylation patterns of key obesogenic genes in Hispanic children would 1) correlate with maternal BMI and 2) allow for identification of pathways associated with children at-risk for obesity.ResultsGenome-wide DNA methylation was conducted on 92 saliva samples collected from Hispanic preschool children using the Infinium Illumina HumanMethylation 450 K BeadChip (Illumina, San Diego, CA, USA), which interrogates >484,000 CpG sites associated with ~24,000 genes. The analysis was limited to 936 genes that have been associated with obesity in a prior GWAS Study. Child DNA methylation at 17 CpG sites was found to be significantly associated with maternal BMI, with increased methylation at 12 CpG sites and decreased methylation at 5 CpG sites. Pathway analysis revealed methylation at these sites related to homocysteine and methionine degradation as well as cysteine biosynthesis and circadian rhythm. Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway.ConclusionsOur study confirms that saliva is a practical human tissue to obtain in community settings and in pediatric populations. These salivary findings indicate potential epigenetic differences in Hispanic preschool children at risk for pediatric obesity. Identifying early biomarkers and understanding pathways that are epigenetically regulated during this critical stage of child development may present an opportunity for prevention or early intervention for addressing childhood obesity.Trial registrationThe clinical trial protocol is available at ClinicalTrials.gov ( NCT01316653 ). Registered 3 March 2011

Discovery of a Mid-infrared Echo from the TDE candidate in the nucleus of ULIRG F01004-2237

We present the mid-infrared (MIR) light curves (LCs) of a tidal disruption event (TDE) candidate in the center of a nearby ultraluminous infrared galaxy (ULIRG) F01004-2237 using archival {\it WISE} and {\it NEOWISE} data from 2010 to 2016. At the peak of the optical flare, F01004-2237 was IR quiescent. About three years later, its MIR fluxes have shown a steady increase, rising by 1.34 and 1.04 mag in $3.4$ and $4.6\mu$m up to the end of 2016. The host-subtracted MIR peak luminosity is $2-3\times10^{44}$\,erg\,s$^{-1}$. We interpret the MIR LCs as an infrared echo, i.e. dust reprocessed emission of the optical flare. Fitting the MIR LCs using our dust model, we infer a dust torus of the size of a few parsecs at some inclined angle. The derived dust temperatures range from $590-850$\,K, and the warm dust mass is $\sim7\,M_{\odot}$. Such a large mass implies that the dust cannot be newly formed. We also derive the UV luminosity of $4-11\times10^{44}$\,erg\,s$^{-1}$. The inferred total IR energy is $1-2\times10^{52}$\,erg, suggesting a large dust covering factor. Finally, our dust model suggests that the long tail of the optical flare could be due to dust scattering

Mid-infrared flare of TDE candidate PS16dtm: dust echo and implications for the spectral evolution

PS16dtm was classified as a candidate tidal disruption event (TDE) in a dwarf Seyfert 1 galaxy with low-mass black hole ($\sim10^6M\odot$) and has presented various intriguing photometric and spectra characteristics. Using the archival WISE and the newly released NEOWISE data, we found PS16dtm is experiencing a mid-infrared (MIR) flare which started $\sim11$ days before the first optical detection. Interpreting the MIR flare as a dust echo requires close pre-existing dust with a high covering factor, and suggests the optical flare may have brightened slowly for some time before it became bright detectable from the ground. More evidence is given at the later epochs. At the peak of the optical light curve, the new inner radius of the dust torus has grown to much larger size, a factor of 7 of the initial radius due to strong radiation field. At $\sim150$ days after the first optical detection, the dust temperature has dropped well below the sublimation temperature. Other peculiar spectral features shown by PS16dtm are the transient, prominent FeII emission lines and outflows indicated by broad absorption lines detected during the optical flare. Our model explains the enhanced FeII emission from iron newly released from the evaporated dust. The observed broad absorption line outflow could be explained by accelerated gas in the dust torus due to the radiation pressure.Comment: Accepted by ApJ, 5 figure

Visualizing metal ions in cells: An overview of analytical techniques, approaches, and probes

AbstractQuantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy. This article is part of a Special Issue entitled: Cell Biology of Metals

Visual impairment and age-related eye diseases in Florida: Findings from 2006 Behavioral Risk Factors Surveillance System (BRFSS) in Nine states

Yan Li, Amy Z Fan, Lina S BalluzBehavioral Surveillance Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USAPurpose: To compare the prevalence of age-related eye disease, visual impairment, and eye care service utilization among adults aged 65 and older in Florida with eight other states. Methods: In 2006, nine states conducted the visual impairment and access to eye care module using the Behavioral Risk Factors Surveillance System (BRFSS) survey (N = 62,750). Visual impairment was based on self-reported ability to see distant and near objects. Age-related eye diseases including cataract, glaucoma, macular degeneration, and diabetic retinopathy were self-reported with diagnosis confirmed by a health care professional. Eye care visit or examination was assessed by whether a respondent reported an eye visit or dilated eye examination within the past year.Results: The estimated prevalence of distant and near visual impairment was lower in Florida than in the eight other states (distant: 11.5% vs 15.2%, P < 0.001; near: 22.3% vs 28.7%, P < 0.001). There was no significant difference with the prevalence of age-related macular degeneration and diabetic retinopathy between these two groups. The prevalence of glaucoma and cataract was higher in Florida. The rates of eye care visits (80.5% vs 74.8%, P < 0.01) and dilated eye examinations (74.7% vs 64.0%, P < 0.01) were higher in Florida. After controlling for demographic variables, chronic conditions, insurance, and eye examination, results for elderly in Florida continued to demonstrate less visually impaired.Conclusion: Fewer elderly in Florida reported visual impairment in spite of comparable or higher prevalence of age-related eye diseases with other states. Health care utilization and health insurance for eye care coverage were also higher in Florida, which may account for the phenomena. More research is needed to investigate the association.Keywords: visual impairment, age-related eye disease, eye care service utilization, health insurance, BRFS

Simulating X-ray Reverberation in the UV-Emitting Regions of Active Galactic Nuclei Accretion Disks with 3D Multi-Frequency Magnetohydrodynamic Simulations

Active galactic nuclei (AGN) light curves observed with different wavebands show that the variability in longer wavelength bands lags the variability in shorter wavelength bands. Measuring these lags, or reverberation mapping, is used to measure the radial temperature profile and extent of AGN disks, typically with a reprocessing model that assumes X-rays are the main driver of the variability in other wavelength bands. To demonstrate how this reprocessing works with realistic accretion disk structures, we use 3D local shearing box multi-frequency radiation magnetohydrodynamic (MHD) simulations to model the UV-emitting region of an AGN disk, which is unstable to the magnetorotational instability (MRI) and convection. At the same time, we inject hard X-rays ($>1$~keV) into the simulation box to study the effects of X-ray irradiation on the local properties of the turbulence and the resulting variability of the emitted UV light curve. We find that disk turbulence is sufficient to drive intrinsic variability in emitted UV light curves and that a damped random walk (DRW) model is a good fit to this UV light curve for timescales $>5$~days. Meanwhile, the injected X-rays have almost no impact on the power spectrum of the emitted UV light curve. In addition, the injected X-ray and emitted UV light curves are only correlated if there is X-ray variability on timescales $>1$~day, in which case we find a correlation coefficient $r=0.52$. These results suggest that hard X-rays with scattering dominated opacity are likely not the main driver of the reverberation signals.Comment: 9 pages, 3 figures, submitted to ApJ

A retrospective evaluation of the effectiveness of a targeted medicines use review service in improving asthma and COPD control provided by community pharmacists in England

Objective Medicines Use Reviews (MUR) may benefit asthma and chronic obstructive pulmonary disease (COPD) control. The present study evaluates the effect of respiratory-targeted MUR-plus (MUR+) services delivered by community pharmacists on disease control. Methods A retrospective analysis of MUR+ data in the PharmOutcomes database was conducted. All patients receiving respiratory-targeted MUR+ in Milton Keynes were included. Changes in asthma control test (ACT) and COPD assessment test (CAT) scores were analysed. Key findings A total of 191 asthma and 81 COPD patients received MUR+. Asthma and COPD control improved as shown by the increase in mean ACT [+1.2 (95% CI, 0.6–1.8)] and decrease in mean CAT [−0.2 (95% CI, −1.4 to 1.0)]. Baseline ACT, smoking cessation, absence of change in drug therapy, patient education, healthcare professional referral, device training and baseline ACT score ≤19 were associated with change in ACT, but only smoking cessation was related to CAT change. A multivariable regression model comprising the aforementioned variables explained 19% of the variance in ACT change (P < 0.001). Only baseline ACT was associated with ACT change (beta = −0.34, P < 0.01). Baseline CAT, absence of change in drug therapy, smoking cessation and baseline CAT score >20 accounted for 12% of the variance in changes in CAT (P = 0.046). No variable was significantly associated with CAT change. Conclusions Respiratory-targeted MUR+ service by community pharmacists was associated with improvements in asthma control among patients with poorer baseline ACT, but not in patients with COPD. Several potentially modifiable factors such as education were associated with changes in control