Commission Proposal for a Regulation on prohibiting products made with forced labour on the Union market:The issue of remedies

The European Union (EU) is committed to the elimination of forced labour, a denial of rights of which there are 28 million victims globally. In September 2022, the European Commission proposed a Regulation to ban all products made by forced labour from the EU market (COM (2022) 453). This proposal has been criticised for failing to facilitate remedies for forced labour victims, in line with EU and global standards such as the United Nations Guiding Principles on Business and Human Rights. This Briefing examines the case for including measures to promote access to effective remediation for victims of forced labour located outside the EU into the Commission’s proposed Regulation. First, it outlines the legal framework for EU action to promote remediation for victims of forced labour located outside EU territory, as well as obstacles to accessibility and effectiveness of remediation for victims in the forced labour context. Second, it considers a range of measures to promote remediation for victims of forced labour that could be incorporated in the Regulation and their feasibility. In conclusion, the Briefing highlights changes to the Commission’s proposed Regulation to advance remediation for victims that are feasible and would increase its alignment with international and EU legal and policy commitments.<br/

A study of the kinematics and binary-induced shaping of the planetary nebula HaTr 4

We present the first detailed spatio-kinematical analysis and modelling of the planetary nebula HaTr 4, one of few known to contain a post-common-envelope central star system. Common envelope evolution is believed to play an important role in the shaping of planetary nebulae, but the exact nature of this role is yet to be understood. High spatial- and spectral- resolution spectroscopy of the [OIII]5007 nebular line obtained with VLT-UVES are presented alongside deep narrowband Ha+[NII]6584 imagery obtained using EMMI-NTT, and together the two are used to derive the three-dimensional morphology of HaTr 4. The nebula is found to display an extended ovoid morphology with an enhanced equatorial region consistent with a toroidal waist - a feature believed to be typical amongst planetary nebulae with post-common-envelope central stars. The nebular symmetry axis is found to lie perpendicular to the orbital plane of the central binary, concordant with the idea that the formation and evolution of HaTr 4 has been strongly influenced by its central binary.Comment: 9 pages, 5 figures, accepted for publication in MNRA

A protocol for unguided internet self-help cognitive behaviour therapy for perfectionism in adolescents at-risk of eating disorders

Perfectionism has a strong association with eating disorders, anxiety and depression. Unguided internet cognitive behaviour therapy for perfectionism has demonstrated efficacy in female adolescents without elevated eating disorder symptoms. No research to date has examined unguided internet cognitive behaviour therapy for perfectionism for adolescents with elevated eating disorder symptoms as an indicated prevention for eating disorders and co-occurring symptoms of anxiety and depression. The protocol outlines the plan for a randomised controlled trial of a co-designed, unguided internet cognitive behaviour therapy for perfectionism with female adolescents with elevated symptoms of eating disorders. The intervention will be a 4-week programme compared to a waitlist control. Outcomes on eating disorder symptoms, anxiety and depression will be measured pre and post intervention and follow-up

Resilient science: The civic epistemology of disaster risk reduction

In this paper, we use insights from science studies to elucidate the nature of advisory science in the context of disasters, particularly those involving geophysical hazards. We argue that there are some key differences between disaster advisory science and the issues that are most discussed in science studies: they are both time- and space-specific and they constitute major social, economic and scientific shocks. We suggest that disasters require flexible advisory structures that maximise the co-production of science and social order, and present a framework for this. We argue that the aim of increasing resilience to natural hazards requires that sociology of scientific knowledge play a part in the application of scientific advice: disaster studies has focused on the reduction of vulnerability as a reaction against technical-rational models of scientific advice, but in doing so has restricted the potential role of the social sciences in the framing of scientific advice and expertise.AD gratefully acknowledges support from a Leverhulme Trust Early Career Fellowship, part-funded by the Isaac Newton Trust, University of Cambridge. AD would also like to thank Professor Susan Owens for productive and enjoyable discussions.This is the author accepted manuscript. The final version is available from Oxford University Press via http://dx.doi.org/10.1093/scipol/scv03

The Radio Light Curve of the Gamma-Ray Nova in V407 Cyg: Thermal Emission from the Ionized Symbiotic Envelope, Devoured from Within by the Nova Blast

We present multi-frequency radio observations of the 2010 nova event in the symbiotic binary V407 Cygni, obtained with the Karl G. Jansky Very Large Array and spanning 1-45 GHz and 17-770 days following discovery. This nova---the first ever detected in gamma rays---shows a radio light curve dominated by the wind of the Mira giant companion, rather than the nova ejecta themselves. The radio luminosity grew as the wind became increasingly ionized by the nova outburst, and faded as the wind was violently heated from within by the nova shock. This study marks the first time that this physical mechanism has been shown to dominate the radio light curve of an astrophysical transient. We do not observe a thermal signature from the nova ejecta or synchrotron emission from the shock, due to the fact that these components were hidden behind the absorbing screen of the Mira wind. We estimate a mass loss rate for the Mira wind of Mdot_w ~ 10^-6 M_sun/yr. We also present the only radio detection of V407 Cyg before the 2010 nova, gleaned from unpublished 1993 archival VLA data, which shows that the radio luminosity of the Mira wind varies by a factor of >~20 even in quiescence. Although V407 Cyg likely hosts a massive accreting white dwarf, making it a candidate progenitor system for a Type Ia supernova, the dense and radially continuous circumbinary material surrounding V407 Cyg is inconsistent with observational constraints on the environments of most Type Ia supernovae.Comment: Resubmitted to ApJ after incorporating referee's comment

Radio studies of novae: a current status report and highlights of new results

Novae, which are the sudden visual brightening triggered by runaway thermonuclear burning on the surface of an accreting white dwarf, are fairly common and bright events. Despite their astronomical significance as nearby laboratories for the study of nuclear burning and accretion phenomena, many aspects of these common stellar explosions are observationally not well-constrained and remain poorly understood. Radio observations, modeling and interpretation can potentially play a crucial role in addressing some of these puzzling issues. In this review on radio studies of novae, we focus on the possibility of testing and improving the nova models with radio observations, and present a current status report on the progress in both the observational front and theoretical developments. We specifically address the issues of accurate estimation of ejecta mass, multi-phase and complex ejection phenomena, and the effect of a dense environment around novae. With highlights of new observational results, we illustrate how radio observations can shed light on some of these long-standing puzzles.Comment: 19 pages, 4 figures. Review article published in the Bulletin of the Astronomical Society of India (BASI) special issue on nova

Paramedics as researchers: A systematic review of paramedic perspectives of engaging in research activity from training to practice

Background: The need for a stronger evidence-base in paramedicine has precipitated a rapid development of pre-hospital research agendas. Paramedics are increasingly involved in research, leading to changes in their role. Yet the integration of research responsibilities has proven to be challenging, resulting in varying attitudes and levels of engagement. Objective: This systematic review aimed to explore paramedics’ views and experiences of research as researchers during training and within practice Methods: A systematic search was undertaken across 6 databases. Qualitative empirical peer-reviewed articles which discussed paramedic perspectives on engaging with research activity were included. Of 10,594 articles initially identified, 11 were included in the final synthesis following quality appraisal. Data were extracted and subjected to narrative synthesis Results: Four themes were identified: motivation to engage, moral dilemmas, structural issues within the profession, and reflections on trial involvement. Attitudes towards research, understanding of related concepts, and the drive for patient benefit were interwoven core issues Conclusion: Research was highly valued when links to patient benefit were obvious, however, this review highlighted some cultural resistance to research, particularly regarding informed consent and changes to standard practice. Paramedic research methods training should provide structured opportunities to explore concerns and emphasize the role of research in developing a high-quality evidence base to underpin safe practice. Currently there is inadequate organisational support for paramedics to engage effectively in research activity, with minimal allocations of time, training, and remuneration. Without properly integrating research activity into the paramedic role, their capacity to engage with research activity is limited

ERK and MMPs Sequentially Regulate Distinct Stages of Epithelial Tubule Development

AbstractEpithelial cells undergo tubulogenesis in response to morphogens such as hepatocyte growth factor (HGF). To organize into tubules, cells must execute a complex series of morphogenetic events; however, the mechanisms that underlie the timing and sequence of these events are poorly understood. Here, we show that downstream effectors of HGF coordinately regulate successive stages of tubulogenesis. Activation of extracellular-regulated kinase (ERK) is necessary and sufficient for the initial stage, during which cells depolarize and migrate. ERK becomes dispensable for the latter stage, during which cells repolarize and differentiate. Conversely, the activity of matrix metalloproteases (MMPs) is essential for the late stage but not the initial stage. Thus, ERK and MMPs define two regulatory subprograms that act in sequence. By inducing these reciprocal signals, HGF directs the morphogenetic progression of tubule development