Virtuelle Realität für Radargeräte in Autos

Car manufacturers spend quite a lot on the development of driver assistance systems and subsequently on autonomous driving functionality. To ensure the safety and reliability of these functions meet industrial standards it is necessary to verify and validate their functionality. While tests on the road are still the ultimate evidence of correct operation they are associated with huge efforts and risks. Therefore, they have to be complemented by other means like simulations and tests on specialised testbeds. For the latter the car’s sensors have to be stimulated in a way that they perceive a desired – but only virtual – environment. An important type of sensor in cars is the radar due to its various advantages. This article describes the development of a stimulator generating virtual radar targets in order to enable the testing of autonomous driving functions. Document type: Articl

Der Nationalsozialismus im Kreis Voitsberg zwischen 1938 und 1945

Meine Dissertation beschäftigt sich mit dem Nationalsozialismus zwischen 1938 und 1945 auf regionaler Ebene. Als Fallbeispiel fungiert der weststeirische Kreis Voitsberg. Im Vordergrund stehen die NS-Akteure vor Ort. Dabei wird besonders auf die lokale NS-Führungsriege eingegangen. Diese besteht aus dem Kreisleiter, den Mitgliedern der Kreisleitung, den Ortsgruppenleitern, den Bürgermeistern und den Ortsbauernführern. Die Kreisleiter nehmen, aufgrund der extrem personalisierten NS-Herrschaftspraxis, eine Sonderstellung ein. Meine zentrale Forschungsfrage dreht sich darum, wie die lokale NS-Führungsriege das Bild des Nationalsozialismus vor Ort mitprägte. Gab es so etwas wie Regionalität im zentralistischen NS-Staat? Der bisherige Forschungsstand zum Nationalsozialismus im Kreis Voitsberg, wird dabei kritisch reflektiert werden. Zum größten Teil bewegt sich meine Dissertation daher in den Bereichen der Regionalgeschichte und der Geschichte des Nationalsozialismus.In inhaltlicher Hinsicht geht es hauptsächlich darum, die Geschehnisse im Kreis Voitsberg zwischen 1938 und 1945 aufzuarbeiten. Im Mittelpunkt stehen dabei erneut die Aktivitäten der lokalen NS-Führungsriege. Neben den NS-Tätern, wird auch auf die Opfer der nationalsozialistischen Herrschaft im Kreis Voitsberg eingegangen werden. Dasselbe gilt für die vielfältigen Formen des Widerstandes gegen den Nationalsozialismus. Zusätzlich zu den Opfern, Tätern und Widerstandskämpfern, beschäftige ich mich mit dem Verhalten der breiten Masse der Bevölkerung, die keiner der drei Kategorien angehörte. Letztendlich ist meine Dissertation ein Beitrag dazu, die Geschehnisse im Kreis Voitsberg in den Jahren zwischen 1938 und 1945 und vor allem die NS-Protagonisten, gezielt zu erforschen. Im Zuge dessen werden möglichst viele jener Bereiche beleuchtet werden, die bisher unerforscht geblieben sind. Dadurch wird erstmals ein umfassender historischer Überblick der NS-Zeit im Kreis Voitsberg entstehen.My dissertation is about the National Socialism between 1938 and 1945 on a local level. The Voitsberg county, located in the west of Styria, serves as a case study. In the center stands the local leadership of the NSDAP. The Kreisleiter, the staff of the Kreisleitung, the mayors and the Ortsbauernführer were part of the local leadership. The Kreisleiter held an exceptional position, because of the extreme personalisation of the NS-ruling system. My main research approach is the question, how the local leadership of the NSDAP influenced the specific form of the National Socialism on a local level. Has there been such a thing as regionalism in the centralistic NS-state? The current state of research of the National Socialism in the county of Voitsberg will be critically reflected. Mainly my dissertation is located between the fields of local history and history of the National Socialism.For the biggest part, the content of my dissertation consists of the events in the Voitsberg county, between 1938 and 1945. Again, the focus lies on the local leadership of the NSDAP. Besides the NS-offenders, the victims of the National Socialism, will also be part of the dissertation. Self same will be effective for the many forms of resistance against the NS-rule. Alongside the offenders, the victims and the resistance fighters, the big mass of the population of the Voitsberg county, which were not part of one of the three categories, will be mentioned. Generally my dissertation is an input to a specific research of the events in the Voitsberg couny between 1938 and 1945, with the NS-protagonists in the focus. In that course as many so far unexplored fields as possible will be illuminated. Thereby, a comprehensive overview of the time of the Nationals Socialist rule in the Voitsberg county, will be provided for the first time.eingereicht von Mag. Martin AmschlZusammenfassung in Deutsch und EnglischAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinKarl-Franzens-Universität Graz, Dissertation, 2016OeBB(VLID)125499

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

Abstract Background Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. α-Syn transgenic mouse models have been developed to investigate the effects of α-Syn accumulation on behavioral deficits and neuropathology. However, the onset and progression of pathology in α-Syn transgenic mice have not been fully characterized. For this purpose we investigated the time course of behavioral deficits and neuropathology in PDGF-β human wild type α-Syn transgenic mice (D-Line) between 3 and 12 months of age. Results These mice showed progressive impairment of motor coordination of the limbs that resulted in significant differences compared to non-transgenic littermates at 9 and 12 months of age. Biochemical and immunohistological analyses revealed constantly increasing levels of human α-Syn in different brain areas. Human α-Syn was expressed particularly in somata and neurites of a subset of neocortical and limbic system neurons. Most of these neurons showed immunoreactivity for phosphorylated human α-Syn confined to nuclei and perinuclear cytoplasm. Analyses of the phenotype of α-Syn expressing cells revealed strong expression in dopaminergic olfactory bulb neurons, subsets of GABAergic interneurons and glutamatergic principal cells throughout the telencephalon. We also found human α-Syn expression in immature neurons of both the ventricular zone and the rostral migratory stream, but not in the dentate gyrus. Conclusion The present study demonstrates that the PDGF-β α-Syn transgenic mouse model presents with early and progressive accumulation of human α-Syn that is accompanied by motor deficits. This information is essential for the design of therapeutical studies of synucleinopathies.</p

Time course and progression of wild type ¿-Synuclein accumulation in a transgenic mouse model

Abstract Background Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. α-Syn transgenic mouse models have been developed to investigate the effects of α-Syn accumulation on behavioral deficits and neuropathology. However, the onset and progression of pathology in α-Syn transgenic mice have not been fully characterized. For this purpose we investigated the time course of behavioral deficits and neuropathology in PDGF-β human wild type α-Syn transgenic mice (D-Line) between 3 and 12 months of age. Results These mice showed progressive impairment of motor coordination of the limbs that resulted in significant differences compared to non-transgenic littermates at 9 and 12 months of age. Biochemical and immunohistological analyses revealed constantly increasing levels of human α-Syn in different brain areas. Human α-Syn was expressed particularly in somata and neurites of a subset of neocortical and limbic system neurons. Most of these neurons showed immunoreactivity for phosphorylated human α-Syn confined to nuclei and perinuclear cytoplasm. Analyses of the phenotype of α-Syn expressing cells revealed strong expression in dopaminergic olfactory bulb neurons, subsets of GABAergic interneurons and glutamatergic principal cells throughout the telencephalon. We also found human α-Syn expression in immature neurons of both the ventricular zone and the rostral migratory stream, but not in the dentate gyrus. Conclusion The present study demonstrates that the PDGF-β α-Syn transgenic mouse model presents with early and progressive accumulation of human α-Syn that is accompanied by motor deficits. This information is essential for the design of therapeutical studies of synucleinopathies