An unusual case of Behçet's disease presenting with postpartum ovarian iliac vein thrombosis and pulmonary embolism

Thrombosis of the ovarian vein is a rare complication which arises classically in the postpartum. We report a case of 24-year-old woman with a history of Behçet's disease, who presented with pelvic and thoracic pain, tachycardia, dyspnea and fever occurring 2 weeks after delivery. Computed tomography revealed an ascending thrombosis of the iliac and right ovarian veins complicated by bilateral pulmonary embolism. The patient responded well to the combination of anticoagulants and immunosuppressive agents. Behçet's disease should also be considered as an etiologic factor for ovarian vein thrombosis

0425: Predictive factors of side effects of amiodarone in the amiotox registry

BackroundAmiodarone is a widely used antiarrhythmic drug in Tunisia and worldwide. However, its side effects are quite frequent hampering its use despite its efficacy.ObjectiveThe purpose of our study was to determin the prevalence of amiodarone side effects and to analyse its predictors in our population.ResultsFrom May 1st 2010 to April 30th 2012, 200 consecutive patients (mean age: 61.9±12.9 years) were included. Mean duration of amiodarone therapy was 51.9±48.4 months with a mean dose of 288.1±274.2g. Atrial fibrillation (81.5%) was the most common indication. Amiodarone side effects occurred in 144 patients (72%). Refering to multivariate analysis, independent predictors were:–Advanced age (p=0.02), treatment duration (p<0.001) and cumulative dose (p<0.001) for occurrence of all side effects.–Treatment duration > 6 months (p=0.008) for corneal deposits.–Age >70 years (p=0.001) and cumulative dose (p<0.00.1 with a logarithmic correlation) for thyroid toxicity.–Cumulative dose (p<0.001) and thyroid disease history (p=0.047) for hypothyroidism.–Age >70 years (p=0.002) and treatment duration (p<0.001 with a linear correlation) for cutaneous toxicity.–Cumulative dose >300g (p=0.012) and heart failure (p= 0.05) for bradycardia.–Cumulative dose >100g (p= 0.012) for QT prolongation–Treatment duration (p<0.001 with a linear correlation) and betablokers concomittent use (p=0.046) for PR elongation.–Treatment duration (p<0.001 with an exponential correlation) and concomittent VKA use (p=0.018) for hepatic toxicity.–Treatment duration > 18 months (p=0.009) and concomittent CCB use (p<0.001) for neurological toxicity.ConlusionThe results of our study confirmed that amiodarone side effects are quite frequent in our population, and that in addition to treatment dose and duration, other predictors for these effects were identified such as age and some drug associations

Water quality in agriculture: Risks and risk mitigation

Edited by: Pay Drechsel, Sara Marjani Zadeh, and Francisco Pedrero SalcedoWater quality is of paramount importance for human lives, food production, and nature, and of concern where agricultural pollution, salinization, or lack of adequate wastewater treatment transform water from a resource into a potential hazard. This is in particular the case in many low- and middle-income countries water treatment is not keeping pace with population growth and urbanization resulting in about 30 million hectares of agricultural land, home to over 800 million residents, irrigated with polluted water. In addition to irrigated crop production, animal husbandry and aquaculture may be greatly affected by poor water quality, and can also contribute significantly to water quality degradation. These challenges prompted the Food and Agriculture Organization of the United Nations (FAO) to publish in 1976 a benchmark publication entitled Water Quality for Agriculture, followed in 1992 by Wastewater Treatment and Use in Agriculture. Over the ensuing 30 years, water quality challenges have grown resulting in a plethora of new research on water pollution, risk assessments and risk mitigation, as well as various sets of new water reuse guidelines. Based on this premise, FAO, in partnership with the International Water Management Institute (IWMI), began production of a review of current water quality guidelines, resulting in this one-volume handbook for evaluating the suitability of water for crop irrigation, livestock and fish production. The publication emphasizes good agricultural practices, including risk mitigation measures suitable for the contexts of differently resourced countries and institutions. With a focus on the sustainability of the overall system, it also covers possible downstream impacts of farm-level decisions. Water Quality in Agriculture: Risks and Risk Mitigation is intended for use by farm and project managers, extension officers, consultants and engineers to evaluate water quality data and identify potential problems and solutions related to water quality, but will also be of value to the scientific research community and studentsThis work started in 2020 under the CGIAR Research Programme on Water, Land and Ecosystems (WLE), and was further supported by the CGIAR initiative on “Resilient Cities through Sustainable Urban and Peri-urban Agrifood Systems” and the CGIAR Fund DonorsPeer reviewe