Effet du chrome niacinate sur la tolérance au glucose chez le rat wistar

Le chrome est un oligoélément essentiel à l’homéostasie du métabolisme glucidique qui pourrait également être impliqué dans l’étiologie de l’athérosclérose. Trois lots de rats Wistar males (n= 30, âgé de 2 mois) traités quotidiennement et pendant 28 jours. Les Contrôles ont reçu du sérum physiologique (1µL/g/j, ip), groupe II a reçu la dexaméthasone (DEX : 0,2 mg/kg/j, ip) et les rats du groupe III ont reçu le même régime que le groupe II avec une supplémentation en CrN à partir du 7 ème jour de l’expérimentation (CrN : 30 mg/kg/j, PO). A la fin de l’expérimentation, les rats sont sacrifiés et les paramètres biochimiques sont dosés. Les résultats montrent une augmentation du poids corporel des rats témoins par apport aux groupes traités par la DEX. La supplémentation en CrN n’a pas corrigé l’élévation de la glycémie et de l’insulinémie engendré par la DEX, de même l’ajout du CrN n’influe pas sur la variation des taux de la triglycéridémie et de la cholestérolémie entrainés par la DEX. Il est notamment observé que l’addition du CrN n’a pas d’effet notable sur la fonction hépatique et la fonction rénale.Mots-clés : chrome, diabète, glycémie, dexaméthasone.Effect of chromium niacinate on glucose tolerance at wistar rat Chromium is an essential trace element in the homeostasis of glucose metabolism could also be involved in the etiology of atherosclerosis. Three groups of male Wistar rats (n= 30, age 2 months) treated daily for 28 days. Controls received saline (1µl/g/day, ip), group II received dexamethasone (DEX: 0, 2 mg/kg/day, ip) and the rats of group III received the same treatment as the group II with supplementation CrN from the 7 day of the experiment (CrN: 30 mg/kg/day, PO). At the end of the experiment, the rats were sacrificed and biochemical parameters were measured. The results show an increase in the body weight of control rats contribution to the DEX treated groups. CrN supplementation did not correct the elevation of blood glucose and insulin caused by DEX. The addition of CrN does not affect the rate of change in triglycerides and cholesterol trained by DEX. It is particularly noted that the addition of CrN has no significant effect on liver and kidney functions.Keywords : chromium, diabetes, glucose, dexamethasone

A prospective, randomised comparison of continuous paravertebral block and continuous intercostal nerve block for post-thoracotomy pain

Background: This study aimed to compare paravertebral block and continuous intercostal nerve block after thoracotomy.Methods: Forty-six adult patients undergoing elective posterolateral thoracotomy were randomised to receive either a continuous intercostal nerve blockade or a paravertebral block. Opioid consumption and postoperative pain were assessed for 48 hours .Pulmonary function was assessed by forced expiratory volume in 1 s (FEV1) recorded at 4 hours intervals.Results: With respect to the objective visual assessment (VAS), both techniques were effective for post thoracotomy pain. The average VAS score at rest was 29±10mm for paravertebral block and 31.5±11mm for continuous intercostal nerve block. The average VAS score on coughing was 36±14mm for the first one and 4 ±14mm for the second group. Pain at rest was similar in both groups. Pain scores on coughing were lower in paravertebral block group at 42 and 48 hours. Post-thoracotomy function was better preserved with paravertebral block. No difference was found among the two groups for side effects related to technique, major morbidity or duration of hospitalisation.Conclusion: We found that continuous intercostal nerve block and paravertebral block were effective and safe methods for post-thoracotomy pain.

Cohomology of the Lie Superalgebra of Contact Vector Fields on R1∣1\mathbb{R}^{1|1} and Deformations of the Superspace of Symbols

Following Feigin and Fuchs, we compute the first cohomology of the Lie superalgebra $\mathcal{K}(1)$ of contact vector fields on the (1,1)-dimensional real superspace with coefficients in the superspace of linear differential operators acting on the superspaces of weighted densities. We also compute the same, but $\mathfrak{osp}(1|2)$-relative, cohomology. We explicitly give 1-cocycles spanning these cohomology. We classify generic formal $\mathfrak{osp}(1|2)$-trivial deformations of the $\mathcal{K}(1)$-module structure on the superspaces of symbols of differential operators. We prove that any generic formal $\mathfrak{osp}(1|2)$-trivial deformation of this $\mathcal{K}(1)$-module is equivalent to a polynomial one of degree $\leq4$. This work is the simplest superization of a result by Bouarroudj [On $\mathfrak{sl}$(2)-relative cohomology of the Lie algebra of vector fields and differential operators, J. Nonlinear Math. Phys., no.1, (2007), 112--127]. Further superizations correspond to $\mathfrak{osp}(N|2)$-relative cohomology of the Lie superalgebras of contact vector fields on $1|N$-dimensional superspace

Unusual cause of severe toxic methemoglobinemia in an infant: a case report

Toxic methemoglobinemia is an uncommon blood disorder induced by exposure to certain oxidizing agents and drugs. In severe cases, this condition may rapidly lead to major cardiopulmonary compromise and constitutes an emergency requiring prompt recognition and early management. We report an unusual case of severe toxic methemoglobinemia following wide cutaneous application of a pomade containing benzocaine, resorcin, and oxyquinoline (Nestosyl®) in an infant

Metasurface-Inspired Flexible Wearable MIMO Antenna Array for Wireless Body Area Network Applications and Biomedical Telemetry Devices

This article presents a sub-6GHz ISM-band flexible wearable MIMO antenna array for wireless body area networks (WBANs) and biomedical telemetry devices. The array is based on metasurface inspired technology. The antenna array consists of 2×2 matrix of triangular-shaped radiation elements that were realized on 0.8 mm thick Rogers RT/duroid 5880 substrate. Radiation characteristics of the array are enhanced by isolating the surface current interaction between the individual radiators in the array. This is achieved by inserting an electromagnetic bandgap (EBG) decoupling structure between the radiating elements. The radiating elements were transformed into a metasurface by etching sub-wavelength slots inside them. The periodic arrangement of slots acts like resonant scatterers that manipulate the electromagnetic response of the surface. Results confirm that by employing the decoupling structure and sub-wavelength slots the isolation between the radiators is significantly improved (>34.8 dB). Moreover, there is an improvement in the array’s fractional bandwidth, gain and the radiation efficiency. The optimized array design for operation over 5.0-6.6 GHz has an average gain and efficiency of 10 dBi and 83%, respectively. Results show that the array’s performance is not greatly affected by a certain amount of bending. In fact, the antenna maintains a gain between 8.65-10.5 dBi and the efficiency between 77-83%. The proposed MIMO antenna array is relatively compact, can be easily fabricated on one side of a dielectric material, allows easy integration with RF circuitry, is robust, and maintains its characteristics with some bending. These features make it suitable for various wearable applications and biomedical telemetry devices

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF)method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of aCAD(Computer AidedDetection) solution and for the assessment of its added value, in order to be applied along with an Immunologist as a second Reader in detection of autoantibodies. This CAD system is able to identify on IIF images the fluorescence intensity and the fluorescence pattern. Preliminary results show that CAD, used as second Reader, appeared to perform better than Junior Immunologists and hence may significantly improve their efficacy; compared with two Junior Immunologists, the CAD system showed higher Intensity Accuracy (85,5% versus 66,0% and 66,0%), higher Patterns Accuracy (79,3% versus 48,0% and 66,2%), and higher Mean Class Accuracy (79,4% versus 56,7% and 64.2%)