ANTI-INFECTIVE AND ANTI-TUMOR ACTIVITY OF SOME METAL COMPLEXES (MII-MIV) WITH SCHIFF BASES

Research and application of metal complexes of ruthenium, platinum, palladium and other d-block elements has been popular in recent time because the complexes of said metals with a wide range of organic ligands shown to be extremely efficient in the treatment of infectious and malignant diseases. In addition to platinum used long time as Cisplatin, Carboplatin and oxaplatin, new generation of anticancer complexes in their structure containe mainly Ru(II) and Ru(III). In the synthesis of anti-infective and anti-tumor drugs, emphasis is indicated on their cytotoxicity. Specifically, the aim is that the new anti-infective and anti-tumor agent does not damage healthy cells and affects only malignant cells or infectious agents. In this paper we make reference on some recent and significant researches in the field of inorganic synthesis of metal complexes with strong anti-tumor and anti-infective properties. Special emphasis is placed on the Schiff bases as organic ligands which are specially used in the synthesis of such agents

Synthesis, spectral characterization, antibacterial and antifungal activity of copper(II)-pABA Complex

pABA (p-aminobenzoic acid or 4-aminobenzoic acid) is a chemical component of the folate molecule produced by plants and bacteria, and found in many foods. It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions. Today it is known that many organic molecules in the human body can react with biometals such as copper, cobalt, manganese, iron and others. This study was performed to investigate the interaction of Cu(II) ions with p-aminobenzoic acid. Spectroscopic methods (FTIR and UV/Vis spectroscopy) were used to characterize the product obtained. The antimicrobial activity of the synthesized complex was tested by diffusion techniques. The results of spectroscopic analysis indicate the interaction of Cu(II) ions with pABA. Interaction is realized through oxygen donor atom of ligand. It was found that the Cu(II) complex has significant antimicrobial activity compared to the pABA ligand

Biodegradable polymers: production, properties and application in medicine

Biodegradable polymers (biopolymers) represent materials of new generation with application in different areas of human activity. Their production has recently reached a commercial level. They can be divided according to the origin (natural and synthetic), according to the chemical composition, methods of obtaining, application etc. The use of biopolymers in medicine depends on their biocompatibility, mechanical resistance, and sorptive char-acteristics. Today, they are the most commonly used as implants in vascular and orthopedic surgery, for the production of materials such as catheters, products for gynaecology and haemodialysis, tooth reconstruction, etc. In pharmacy, they are used as a medicine matrix-carrier to allow controlled release of drug within the body. Within this review paper, the properties and methods of production of certain biopolymers such as polyglycolic acid (PGA), polylactide acid (PLA), poly-ε-coprolactone (PCL) and polybutylene succinate (PBS) will be described in detail, as well as their application in medicine and pharmacy

Synthesis, characterization and bioactivity of selected metal complexes with imine ligands

The chemistry of complex compounds containing imine ligands is attracting significant attention from researchers today. In this work, complexes of selected transition metals (Cu, Co, Ni and Fe) with imines based on ninhydrin and amino acids methionine and cysteine were synthesized. FTIR and UV/VIS spectroscopy were used for structural characterization. Antioxidant activity of the complex was analyzed by the FRAP method. The synthesized compounds showed a significant reducing ability, ranging from 221.94 to 756.30 µmol/L. In vitro antimicrobial activity was tested on strains from the ATCC collection. Inhibitory activity against the tested microorganisms was recorded, and the zones of inhibition ranged from 10-24 mm. Preliminary research shows that these compounds have biological potency, but more detailed in vitro and in vivo studies are required for their use.</p

Synthesis, spectral characterization and antimicrobial activity of M(II) complexes with tridentate ligand Ciprofloxacin

Ciprofloxacin, CFL is a drug that belongs to the second generation of fluoroquinolone antibiotics with a wide range of effects on Gram-positive and Gram-negative bacteria. The aim of this work was to investigate the interaction of CFL as ligand with divalent biological cations (Mn2+, Ni2+ and Co2+) in approximate physiological conditions. Synthesized complexes were characterized using FTIR and stereo-microscopy. Antimicrobial screening was performed on bacterial strains of Escherichia coli, Salmonella Enteritidis, Enterococcus faecalis and Staphylococcus aureus. The results of FTIR spectroscopy showed that the M(II) complexes with CFL were formed through the oxygen donors of the carboxyl and carbonyl group of the ligand. Stereo-microscopic characterization revealed the difference in color and size of crystals of the ligand and metal complexes. Antimicrobial screening has shown that CFL and complexes have almost similar antimicrobial activity against investigated bacterial strains. Keywords: complex, CPF, antimicrobial activity,  morphological characterization, FTI