The Influence of Expectancy Persuasion Techniques on Socially Anxious Analogue Patients\u27 Treatment Beliefs and Therapeutic Actions

Although patients’ psychotherapy outcome expectations correlate with posttreatment outcome, there is limited research explicating treatment elements that causally influence these expectations. Most relevant studies have focused on varied deliveries of a treatment rationale. Although elements of rationale delivery appear important for altering patients’ expectations, many studies have been marked by methodological shortcomings, such as lack of a control group. In this clinical analogue experiment, I examined the influence of expectancy persuasion methods, delivered in a video-based presentation of a cognitive-behavioral treatment rationale for social anxiety, on analogue patients’ post-rationale treatment beliefs, treatment motivation, social anxiety symptoms, and therapeutic action. One hundred and seventy-eight undergraduates screened for elevated social anxiety, and matched for sex and treatment history, were randomized to the experimental (rationale plus expectancy persuasion video) or comparison (rationale only video) group. Consistent with my hypotheses, there were significant increases across both groups in anxiety change expectations, perceived confidence in using CBT exposure techniques to address social anxiety, and perceived helpfulness of exposure techniques. Counter to my predictions, no other effects of time, group, or their interaction emerged for the various dependent variables. Additionally, exploration of socioeconomic status, conceptualization of social anxiety, and initial anxiety change expectations as potential moderators of group effects on the dependent variables revealed no significant findings. The results underscore the clinical importance of delivering a clear treatment rationale; however, they also suggest that the specific methods for persuading patients’ treatment beliefs and activities may have lacked sufficient potency to augment the effects of general rationale delivery

Environmental DNA assessment of airborne plant and fungal seasonal diversity

Environmental DNA (eDNA) metabarcoding and metagenomics analyses can improve taxonomic resolution in biodiversity studies. Only recently, these techniques have been applied in aerobiology, to target bacteria, fungi and plants in airborne samples. Here, we present a nine-month aerobiological study applying eDNA metabarcoding in which we analyzed simultaneously airborne diversity and variation of fungi and plants across five locations in North and Central Italy. We correlated species composition with the ecological characteristics of the sites and the seasons. The most abundant taxa among all sites and seasons were the fungal genera Cladosporium, Alternaria, and Epicoccum and the plant genera Brassica, Corylus, Cupressus and Linum, the latter being much more variable among sites. PERMANOVA and indicator species analyses showed that the plant diversity from air samples is significantly correlated with seasons, while that of fungi varied according to the interaction between seasons and sites. The results consolidate the performance of a new eDNA metabarcoding pipeline for the simultaneous amplification and analysis of airborne plant and fungal particles. They also highlight the promising complementarity of this approach with more traditional biomonitoring frameworks and routine reports of air quality provided by environmental agencies

Two benthic diatoms, nanofrustulum shiloi and striatella unipunctata, encapsulated in alginate beads, influence the reproductive efficiency of paracentrotus lividus by modulating the gene expression

Physiological effects of algal metabolites is a key step for the isolation of interesting bioactive compounds. Invertebrate grazers may be fed on live diatoms or dried, pelletized, and added to compound feeds. Any method may reveal some shortcomings, due to the leaking of wound-activated compounds in the water prior to ingestion. For this reason, encapsulation may represent an important step of bioassay-guided fractionation, because it may assure timely preservation of the active compounds. Here we test the effects of the inclusion in alginate (biocompatible and non-toxic delivery system) matrices to produce beads containing two benthic diatoms for sea urchin Paracentrotus lividus feeding. In particular, we compared the effects of a diatom whose influence on P. lividus was known (Nanofrustulum shiloi) and those of a diatom suspected to be harmful to marine invertebrates, because it is often present in blooms (Striatella unipunctata). Dried N. shiloi and S. unipunctata were offered for one month after encapsulation in alginate hydrogel beads and the larvae produced by sea urchins were checked for viability and malformations. The results indicated that N. shiloi, already known for its toxigenic effects on sea urchin larvae, fully conserved its activity after inclusion in alginate beads. On the whole, benthic diatoms affected the embryogenesis of P. lividus, altering the expression of several genes involved in stress response, development, skeletogenesis and detoxification processes. Interactomic analysis suggested that both diatoms activated a similar stress response pathway, through the up-regulation of hsp60, hsp70, NF-κB, 14-3-3 ε and MDR1 genes. This research also demonstrates that the inclusion in alginate beads may represent a feasible technique to isolate diatom-derived bioactive compounds

Topical corticosteroid phobia in parents of pediatric patients with atopic dermatitis: a multicentre survey

BACKGROUND: Families of children affected with atopic dermatitis (AD) often report fear and anxiety regarding treatment with topical corticosteroids (TCS), which may lead to reduced compliance. The objective of our study was to measure, through a standardized questionnaire, fear of TCS in families of pediatric patients with AD and to identify items associated with fear. METHODS: Families of pediatric patients with AD were enrolled in 9 Italian centers of pediatric dermatology. Enrolled parents were invited to fill in a questionnaire including questions on sociodemographic and clinical characteristics and 3 sets of questions on corticosteroid phobia (general fear, specific fears, behaviours regarding TCS). Determinants of the level of general fear were investigated through multivariable analysis. RESULTS: A total of 300 outpatients with AD were enrolled. Most parents (80%) had a high instruction level. Eighty-one percent reported to have a certain amount of fear of TCS. At the multivariable analysis, fear of TCS was associated with the following items: believing that TCS treatment advantages do not overweight disadvantages (P = 0.011); believing that TCS may be dangerous independently from the specific side effect (P < 0.001). Moreover, TCS fear was associated with fear of applying too much cream (P = 0.001). CONCLUSION: TCS phobia is widespread among Italian families of children with AD. Fear of TCS is associated with fear of applying too much cream, thus increasing the risk of poor compliance and treatment failure. Therapeutic education of families on the use of TCS should be implemented. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13052-017-0330-7) contains supplementary material, which is available to authorized users

Convexity Adjustment for Constant maturity Swaps in a Multi-Curve Framework

In this paper we propose a double curving setup with distinct forward and discount curves to price constant maturity swaps (CMS). Using separate curves for discounting and forwarding, we develop a new convexity adjustment, by departing from the restrictive assumption of a flat term structure, and expand our setting to incorporate the more realistic and even challenging case of term structure tilts. We calibrate CMS spreads to market data and numerically compare our adjustments against the Black and SABR (stochastic alpha beta rho) CMS adjustments widely used in the market. Our analysis suggests that the proposed convexity adjustment is significantly larger compared to the Black and SABR adjustments and offers a consistent and robust valuation of CMS spreads across different market conditions

Patient Outcome Expectations and Credibility Beliefs as Predictors of the Alliance and Treatment Outcome

The clinical relevance of patients’ psychotherapy outcome expectations has been substantiated by a fairly robust correlational literature. Furthermore, as a related yet distinct construct, patients’ treatment credibility beliefs have also been associated with positive treatment outcomes. Addressing several methodological limitations of past research, the current study examined the influence on early adaptive process (patient-psychotherapist alliance quality) and early treatment outcome (patient distress level) of patients’ outcome expectations and credibility beliefs, measured both statically and dynamically with a psychometrically sound self-report instrument. Patients were 110 adult outpatients receiving naturalistically delivered psychotherapy in a community mental health training clinic. The primary research questions were tested with a series of hierarchical multiple regression models, which revealed: (a) An increase in patients’ initial outcome expectations (from baseline to post-session 1) was positively associated with patient rated alliance quality at session 7 (B = 1.28, p \u3c .05), and (b) early (post-session 1) outcome expectations (B = 1.13, p \u3c .05) and credibility beliefs (B = .83, p \u3c .05) significantly predicted patient rated early alliance. The findings further underscore the clinical importance of patients’ treatment beliefs, and they are discussed with respect to their empirical and clinical implications