388 research outputs found
Antidepressants cheer up hepatic B1 B cells: Hope for the treatment of autoimmune liver diseases?
Modified Bell-Plesset Effect with Compressibility: Application to Double-Shell Ignition Target Designs
The effect of spherical convergence on the fluid stability of collapsing and expanding bubbles was originally treated by Bell [Los Alamos Scientific Laboratory Report No. LA-1321 (1951)] and Plesset [J. Appl. Phys. 25, 96 (1954)]. The additional effect of fluid compressibility was also considered by Bell but was limited to the case of nonzero density on only one side of a fluid interface. A more general extension is developed which considers distinct time-dependent uniform densities on both sides of an interface in a spherically converging geometry. A modified form of the velocity potential is used that avoids an unphysical divergence at the origin [Goncharov et al., Phys. Plasmas 7, 5118 (2000); Lin et al., Phys. Fluids 14, 2925 (2002)]. Two consequences of this approach are that an instability proposed by Plesset for an expanding bubble in the limit of large interior density is now absent and application to inertial confinement fusion studies of stability becomes feasible. The model is applied to a proposed ignition double-shell target design [Amendt et al., Phys. Plasmas 9, 2221 (2002)] for the National Ignition Facility [Paisner et al., Laser Focus World 30, 75 (1994)] for studying the stability of the inner surface of an imploding high-Z inner shell. Application of the Haan [Phys. Rev. A 39, 5812 (1989)] saturation criterion suggests that ignition is possible
Analysing forensic entomology data using additive mixed effects modelling
© Springer Science+Business Media B.V. 2010. Forensic pathologists and entomologists estimate the minimum post-mortem interval since a long time by describing the stage of succession and development of the necrophagous fauna (Amendt et al. 2004). From very simple calculations at the beginning, (Bergeret, see also Smith 1986) the discipline has evolved into a more mathematical one (e.g. Marchenko 2001; Grassberger and Reiter 2001, 2002) and tries to implement concepts like probabilities and confidence intervals (Lamotte and Wells 2000; Donovan et al. 2006; Tarone and Foran 2008, see also Villet et al. this book Chapter7). As pointed out by Tarone and Foran (2008) and Van Laerhoven (2008), the latter is one of the major tenets of the Daubert Standard (Daubert et al. v. Merrell Dow Pharmaceuticals (509 U.S. 579 (1993))
Assessment of ion kinetic effects in shock-driven inertial confinement fusion implosions using fusion burn imaging
The significance and nature of ion kinetic effects in D3He-filled, shock-driven inertial confinement
fusion implosions are assessed through measurements of fusion burn profiles. Over this series of
experiments, the ratio of ion-ion mean free path to minimum shell radius (the Knudsen number,
NK) was varied from 0.3 to 9 in order to probe hydrodynamic-like to strongly kinetic plasma
conditions; as the Knudsen number increased, hydrodynamic models increasingly failed to match
measured yields, while an empirically-tuned, first-step model of ion kinetic effects better captured
the observed yield trends [Rosenberg et al., Phys. Rev. Lett. 112, 185001 (2014)]. Here, spatially
resolved measurements of the fusion burn are used to examine kinetic ion transport effects in
greater detail, adding an additional dimension of understanding that goes beyond zero-dimensional
integrated quantities to one-dimensional profiles. In agreement with the previous findings, a comparison
of measured and simulated burn profiles shows that models including ion transport effects
are able to better match the experimental results. In implosions characterized by large Knudsen
numbers (NK3), the fusion burn profiles predicted by hydrodynamics simulations that exclude
ion mean free path effects are peaked far from the origin, in stark disagreement with the experimentally
observed profiles, which are centrally peaked. In contrast, a hydrodynamics simulation that
includes a model of ion diffusion is able to qualitatively match the measured profile shapes.
Therefore, ion diffusion or diffusion-like processes are identified as a plausible explanation of the
observed trends, though further refinement of the models is needed for a more complete and
quantitative understanding of ion kinetic effects
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Life Pure Fusion Target Designs: Status and Prospects
Analysis and radiation-hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant are presented. The required laser energy driver is 2.2 MJ at a 0.351-{mu}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for near-term experimental resolution of the key physics uncertainties on the National Ignition Facility
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Laser Plasma instability reduction by coherence disruption
The saturation levels of stimulated scattering of intense laser light in plasmas and techniques to reduce these levels are of great interest. A simple model is used to highlight the dependence of the reflectivity on the coherence length for the density fluctuations producing the scattering. Sometimes the coherence lengths can be determined nonlinearly. For NIF hohlraum plasmas, a reduction in the coherence lengths might be engineered in several ways. Finally, electron trapping in ion sound waves is briefly examined as a potentially important effect for the saturation of stimulated Brillouin scattering
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Highly-resolved 2D HYDRA simulations of Double-Shell Ignition Designs
Double-shell (DS) targets (Amendt, P. A. et al., 2002) offer a complementary approach to the cryogenic baseline design (Lindl, J. et al., 2004) for achieving ignition on the National Ignition Facility (NIF). Among the expected benefits are the ease of room temperature preparation and fielding, the potential for lower laser backscatter and the reduced need for careful shock timing. These benefits are offset, however, by demanding fabrication tolerances, e.g., shell concentricity and shell surface smoothness. In particular, the latter is of paramount importance since DS targets are susceptible to the growth of interface perturbations from impulsive and time-dependent accelerations. Previous work (Milovich, J. L. et al., 2004) has indicated that the growth of perturbations on the outer surface of the inner shell is potentially disruptive. To control this instability new designs have been proposed requiring bimetallic inner shells and material-matching mid-Z nanoporous foam. The challenges in manufacturing such exotic foams have led to a further evaluation of the densities and pore sizes needed to reduce the seeding of perturbations on the outer surface of the inner shell, thereby guiding the ongoing material science research efforts. Highly-resolved 2D simulations of porous foams have been performed to establish an upper limit on the allowable pore sizes for instability growth. Simulations indicate that foams with higher densities than previously thought are now possible. Moreover, while at the present time we are only able to simulate foams with average pore sizes larger than 1 micron (due to computational limitations), we can conclude that these pore sizes are potentially problematic. Furthermore, the effect of low-order hohlraum radiation asymmetries on the growth of intrinsic surface perturbations is also addressed. Highly-resolved 2D simulations indicate that the transverse flows that are set up by these low-order mode features (which can excite Kelvin-Helmholtz instabilities) are not large enough to offset the overall robustness of our current design
Plasma adiabatic lapse rate
The plasma analog of an adiabatic lapse rate (or temperature variation with
height) in atmospheric physics is obtained. A new source of plasma temperature
gradient in a binary ion species mixture is found that is proportional to the
concentration gradient and difference in average ionization states .
Application to inertial-confinement-fusion implosions indicates a potentially
strong effect in plastic (CH) ablators that is not modeled with mainline
(single-fluid) simulations. An associated plasma thermodiffusion coefficient is
derived, and charge-state diffusion in a single-species plasma is also
predicted
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Stauts of the Laser Inertial Fusion Energy (LIFE) Hohlraum Point Design
Progress on the hohlraum point design for the LIFE engine is described. New features in the original design [Amendt et al., Fus. Sci. Technol. 60, 49 (2011)] are incorporated that address the imperatives of low target cost, high manufacturing throughput, efficient and prompt material recycling, an ability for near-term testing of key target design uncertainties on the National Ignition Facility, and robustness to target chamber environment and injection insults. To this end, the novel use of Pb hohlraums and aerogel-supported liquid DT fuel loading within a high-density-carbon (HDC) ablator is implemented in the hohlraum point design
Estimating the age of Calliphora vicina eggs (Diptera: Calliphoridae): determination of embryonic morphological landmarks and preservation of egg samples
ORCID No. 0000-0002-8917-9646© The Author(s) 2016. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The attached file is the published version of the article
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