Effect of section thickness on fatigue performance of laser sintered nylon 12

Laser Sintering offers manufacturers freedom of design, which enables creating parts with complex geometries. However, very little investigation has been made into the effects of geometry on mechanical properties of the parts. In the present study, Laser Sintered Nylon 12 parts with different section thickness are subjected to displacement controlled tension-tension and force-controlled fully reversed fatigue loading to investigate the effect of geometry on their fatigue behavior. Section thickness of the parts is shown to have no significant influence on the fatigue behavior under tension only loading. However, fatigue life of parts under fully reversed loading is shown to increase with section thickness

INTELLIGENT SURVEILLANCE SYSTEM FOR FIRE DETECTION USING YOLOV8

This study describes a lightweight deep learning model trained on a self-made image dataset taken inside farms and open areas of the Holy Shrine of Al-Hussainiya in the City of Karbala, Iraq. This dataset includes fire and smoke images taken using a Samsung A52S camera in different weather conditions. The overall goal is to create a fire detection system model that can successfully replace the existing physical sensor-based fire detectors and lessen the issues that come with such fire detectors, including false and delayed triggering. Another goal is to control fires on farms or open areas and prevent crop damage as much as possible. Previous studies were reviewed. Moreover, the architecture of the You Only Look Once version 8 (YOLOv8) model was briefly explained, and the results it achieved were compared with those achieved by previous versions. Then, the proposed system was trained and evaluated with the YOLOv8 large model. Results showed that the proposed system outperformed the rest of the current systems in mAP, which reached 98.5%

Study of free surface flows in rectangular channel over rough beds.

This paper presents the results of an experimental and umerical study of fully developed flow in a straight rectangular open channel over rough beds. Conical ribs were placed on the flume bottom to simulate different bed roughness conditions. Acoustic Doppler Velocimetry (ADV) measurements were made to obtain the velocity components profiles as well as the Reynolds stress profiles, at various locations. The experimental results are validated by simulations using an algebraic stress model. These investigations could be useful for researches in the field of sediment transport, bank protection, etc

Texture features extraction based on GLCM for face retrieval system

Texture features play an important role in most image retrieval techniques to obtain results of high accuracy. In this work, the face image retrieval method considering texture analysis and statistical features has been proposed. Textile features can also be extracted using the GLCM tool. In this research, the GLCM calculation method involves two phases, first: some of the previous image processing techniques work together to get the best results to determine the big object of the face image (center of face image) then, the gray level co-occurrence matrix GLCM is computed for gray face image and then some statistical texture features with second-order are extracted. In the second phase, the facial texture features are retrieved by finding the minimum distance between texture features of an unknown face image with the texture features of face images that are stored in the database system. The experimental results show that the proposed method is capable to achieve high accuracy degree in face image retrieval

Cell Cycle Response to Low Power Laser Irradiation in Jurkat E6.1 T-lymphocyte Cell Line

Low-power laser irradiation (LPLI) effects on cell cycle progression in Jurkat E6.1 T-lymphocyte leukemia (JETL) cells were examined in vitro at 635nm (visible) and 780nm (near infrared) wavelengths. The cells were exposed to an energy density of 9.174 J/cm2, and then examined 24, 48 and 72 hours post-irradiation. Cell cycle analysis by flow cytometry at 24 hours post-irradiation revealed that the three phases (G0/G1, S and G2/M) of cultured JETL cells showed different percentages in LPLI (635nm and 780nm) and unirradiated cultures, but S phase cells were observed with significant increased percentages (55.6 and 55.7%, respectively) compared to controls (37.3%). At 48 hours, again cells at S phase were observed with much higher percentages than control cells (48.2 and 51.5% vs. 29.9%, respectively), and the difference was significant (P ? 0.05). At 72 hours, the S phase cells were also observed with much higher percentages than control cells (33.1 and 32.6% vs. 21.3%, respectively), and the difference was also significant (P ? 0.05). Keywords: Cell cycle, Jurkat E6.1 T-lymphocyte leukemia cell line, Low-power laser irradiation

Effect of High-Intensity Focused Ultrasound on Vaginal Relaxation Syndrome

This study was conducted to determine the effect of high-intensity focused ultrasound (HIFU) on vaginal relaxation syndrome (VRS). Thirty sexually active women suffering from vaginal laxity aged 30-45 years participated in this study. Vaginal laxity is often overlooked and underreported, yet it significantly impacts sexual functioning, self-image, and overall quality of life (QoL) in women. These women were randomly assigned to two groups: control group (15 women) received pelvic floor exercises daily for 8 weeks and study group (15 women) received the same exercises daily for 8 weeks plus 2 sessions of HIFU with 4 weeks apart. Evaluation was done before and after the treatment program by vaginal laxity questionnaire (VLQ), sexual satisfaction questionnaire (SSQ), and female sexual function index-19 (FSFI-19) to assess sexual health; International Consultation on Incontinence Questionnaire short-form (ICIQ-SF) to evaluate urinary symptoms; vaginal pH strip to evaluate vaginal pH; vaginal pressure gauge to assess vaginal wall elasticity; and ultrasonographic imaging to assess pelvic floor biometers. The post-treatment results revealed significant improvements in VLQ, SSQ, all domains and total score of FSFI-19, ICIQ-SF, vaginal pH, intravaginal pressure, the length from symphysis pubis to anorectal angle at rest and at contraction, as well as the anteroposterior and transverse diameters, and area of the levator ani hiatus at rest and at Valsalva (p\u3c0.05) in favour of the study group. High intensity focused ultrasound is an effective and safe modality for improving sexual health, urinary symptoms, vaginal pH, vaginal wall elasticity, and pelvic floor biometers in women with vaginal relaxation syndrome

SYNTHESIS, ANTITUMOR ACTIVITY, PHARMACOPHORE MODELING AND QSAR STUDIES OF NOVEL PYRAZOLES AND PYRAZOLO [1, 5-A] PYRIMIDINES AGAINST BREAST ADENOCARCINOMA MCF-7 CELL LINE

Objective: The present work aimed to synthesize New series of pyrazoles 3 and pyrazolo[1,5-a]pyrimidines 5, 7, 9 in order to evaluate their antiproliferative activity against human breast adenocarcinoma MCF-7cell line and study the cell cycle progression of the most active compounds. In addition, Pharmacophore modeling and QSAR Studies of these new compounds were done.Methods: The diazonium salt of 4-aminoacetophenone 1 was coupled with malononitrile in ethanol using sodium acetate affords 2-[(4-acetylphenyl)diazenyl] malononitrile Cycloaddition of hydrazine hydrate, in molar ratios 1:1 or 1:2, on compound 2, furnished 3,5-diaminopyrazolederivatives 3a and 3b respectively. Moreover, new pyrazolo[1,5-a]pyrimidine derivatives 5a-f were obtained upon cyclocondensation of 3a, b with different chalcones 4a-c in EtOH/piperidine,while compounds 7a-f were prepared via cycloaddition of 3a, b with various arylidene malononitriles 6a-c in the same reaction condition. Finally, treatment of 3a, b with ethyl 2-cyano-3-ethoxyacrylate 8a or 2-(ethoxymethylene)malononitrile 8b in EtOH/TEA yielded the novel pyrazolo[1,5-a]pyrimidine derivatives 9a, b respectively. These target compounds were screened for their cytotoxic activity against MCF-7 (human breast Cell Line) followed by study cell cycle of 7a. Finally, Pharmacophore modeling and QSAR Studies was carried out.Results: The pyrazolopyrimidine 7a was the most active compound (IC50 = 3.25 µM), whereas, some of the tested compounds exploited moderate growth inhibitory activity. Its effect was further studied on cell cycle progression; results showed that compound 7a induced cell cycle arrest at S-phase verifying this compound as a promising selective anticancer agent.Conclusion: Compound 7a was found to be the most active member against MCF-7 breast cancer (IC50= 3.25 μM), Further biological assessment of 7a using flow-cytometric analysis, revealed that it induced cell cycle arrest at S phase.Keywords: Pyrazole, Pyrazolo[1,5-a]pyrimidine, MCF-7 breast cancer cell line, Cell cycle profile, 3D pharmacophore,1 QSAR stud