From Radio to X-ray: Flares on the dMe Flare Star EV Lacertae

We present the results of a campaign to observe flares on the M dwarf flare star EV Lacertae over the course of two days in 2001 September, utilizing a combination of radio continuum, optical photometric and spectroscopic, ultraviolet spectroscopic, and X-ray spectroscopic observations, to characterize the multi-wavelength nature of flares from this active, single late-type star. We find flares in every wavelength region in which we observed. In the multi-wavelength context, the start of the intense radio flare is coincident with an impulsive optical U-band flare, to within one minute, and yet there is no signature of an X-ray response. There are other intervals of time where optical flaring and UV flaring is occurring, but these cannot be related to the contemporaneous X-ray flaring: the time-integrated luminosities do not match the instantaneous X-ray flare luminosity, as one would expect for the Neupert effect. We investigate the probability of chance occurrences of flares from disparate wavelength regions producing temporal coincidences, but find that not all the flare associations can be explained by a superposition of flares due to a high flaring rate. We caution against making causal associations of multi-wavelength flares based solely on temporal correlations for high flaring rate stars like EV Lac.Comment: 52 pages, 13 figures, accepted for publication in the Astrophysical Journa

Two Cases from Central America: Attitudes of Political Elites in Panama and Guatemala

Panama and Guatemala represent two very different political experiences in the Central American region. Also their political elites show different patterns. The disparities in their recent histories, their economies, and their formal and informal institutions have impacted on their representation and composition of their elites. Both countries are characterized by the influence of economy on politics. However, while in Panama the wealth of the canal has contributed to political stability, in Guatemala the old oligarchies have preserved its power by preventing the strengthening of institutions. Nonetheless, in spite of the issues that affect each country, there may be some similarities. One of them is the lack of ideology in their party system. Despite of that elites are able to self-locate themselves in the left-right axis and also their parties, their programs and polices are rather pragmatic and their organizational structures are dominated by a few prominent personalities. In order to show empirical evidences of the differences and similarities between both countries, this chapter maps out elites attitudes on different dimensions of the political system

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Ferroptosis is a death program executed via selective oxidation of arachidonic acid-phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic bacterium, Pseudomonas aeruginosa, that does not contain AA-PE can express lipoxygenase (pLoxA), oxidize host AA-PE to 15-hydroperoxy-AA-PE (15-HOO-AA-PE), and trigger ferroptosis in human bronchial epithelial cells. Induction of ferroptosis by clinical P. aeruginosa isolates from patients with persistent lower respiratory tract infections was dependent on the level and enzymatic activity of pLoxA. Redox phospholipidomics revealed elevated levels of oxidized AA-PE in airway tissues from patients with cystic fibrosis (CF) but not with emphysema or CF without P. aeruginosa. We believe that the evolutionarily conserved mechanism of pLoxA-driven ferroptosis may represent a potential therapeutic target against P. aeruginosa-associated diseases such as CF and persistent lower respiratory tract infections