Corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops

Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours.Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays

Electrical transport properties of microcrystalline silicon grown by PECVD

The dark conductivity and Hall mobility of hydrogenated silicon films deposited varying the silane concentration f=SiH4/(SiH4+H2) in a conventional plasma enhanced chemical vapor deposition system have been investigated as a function of temperature, taking into account their structural properties. The electrical properties have been studied in terms of a structural two-phase model. A clear transition from the electrical transport governed by a crystalline phase, in the range 1%3%, has been evidenced. Some metastable effects of the dark conductivity have been noticed

Structural and electrical properties of nanostructured silicon carbon films

Abstract The effect of the rf power on the structural and electrical properties of nanostructured silicon carbon films deposited by Plasma Enhanced Chemical Vapour Deposition system, using silane and methane gas mixture highly diluted in hydrogen, has been investigated. The structural and electrical properties are found to depend strongly on rf power. The increase of the rf power decreases the size of the silicon crystallites as well as the crystalline fraction and increases the carbon content in the films. The study not only indicates the correlation between crystalline fraction and the electrical conductivity but also reveals the presence of nanocrystallites in the films deposited at high rf power

Influence of the thermomechanical characteristics of low-density polyethylene substrates on the thermoresistive properties of graphite nanoplatelet coatings

Morphological, structural, and thermoresistive properties of films deposited on low-density polyethylene (LDPE) substrates are investigated for possible application in flexible electronics. Scanning and transmission electron microscopy analyses, and X-ray diffraction measurements show that the films consist of overlapped graphite nanoplatelets (GNP) each composed on average of 41 graphene layers. Differential scanning calorimetry and dynamic-mechanical-thermal analysis indicate that irreversible phase transitions and large variations of mechanical parameters in the polymer substrates can be avoided by limiting the temperature variations between −40 and 40◦ C. Electrical measurements performed in such temperature range reveal that the resistance of GNP films on LDPE substrates increases as a function of the temperature, unlike the behavior of graphite-based materials in which the temperature coefficient of resistance is negative. The explanation is given by the strong influence of the thermal expansion properties of the LDPE substrates on the thermo-resistive features of GNP coating films. The results show that, narrowing the temperature range from 20 to 40◦ C, the GNP on LDPE samples can work as temperature sensors having linear temperature-resistance relationship, while keeping constant the temperature and applying mechanical strains in the 0–4.2 × 10−3 range, they can operate as strain gauges with a gauge factor of about 48

KM3NeT performance on oscillation and absorption tomography of the Earth

The KM3NeT neutrino telescope, currently under construction, consists of two detectors in the Mediterranean Sea, ORCA and ARCA, both using arrays of optical modules to detect the Cherenkov light produced by charged particles created in neutrino interactions. Although originally designed for neutrino oscillation and astrophysical research, this experiment also bears unprecedented possibilities for other fields of physics. Here we present its performance for neutrino tomography, i.e. the study of the Earth’s internal structure and composition. Owing to the different energy ranges covered by its two detectors ORCA and ARCA, KM3NeT will be the first experiment to perform both oscillation and absorption neutrino tomography. Resonance effects in the oscillations of GeV neutrinos traversing the Earth will allow KM3NeT/ORCA to measure the electron density along their trajectory, leading to potential constraints of the proton-to-nucleon (Z/A) ratio in the traversed matter. Absorption tomography aims at the detection of neutrinos in the TeV-PeV range with KM3NeT/ARCA. At PeV energies, the Earth is opaque for neutrinos which leads to a reduction of the upgoing neutrino flux at the detector side from which conclusions can be drawn about the density of the inner layers of the Earth. We show here first sensitivity studies of the potential of KM3NeT to address open questions of geophysics concerning the chemical composition and matter distribution in the Earth’s core and mantle through neutrino tomography.Article signat per 297 autors/es: M.Ageron, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulakis, M. Anghinolfi, M. Anguita, G. Anton, M. Ardid, S. Ardid, W. Assal, J. Aublin, C. Bagatelas, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A. M. van den Berg, V. Bertin, S. Beurthey, V. van Beveren, S. Biagi, M. Billault, M. Bissinger, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, C. Boutonnet, G. Bouvet, M. Bouwhuis, C. Bozza, H.Brânzas, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, L. Caillat, D. Calvo, S. Campion, A. Capone, H. Carduner, V. Carretero, P. Castaldi, S. Celli;, R. Cereseto, M. Chabab, C. Champion, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, S. Colonges, R. Coniglione, A. Cosquer, P. Coyle, M. Cresta, A. Creuso, A. Cruz, G. Cuttone, A. D’Amico, R. Dallier, B. De Martino, M. De Palma, I. Di Palma, A. F. Díaz, D. Diego- Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, H. Eljarrari, D. Elsaesser, A. Enzenhöfer, V. Espinosa, P. Fermani, G. Ferrara, M. D. Filipovic, F. Filippini, J. Fransen, L. A. Fusco, D. Gajanana, T. Gal, J. García Méndez, A. Garcia Soto, E. Garçon, F. Garufi, C. Gatius, N. Geißelbrecht, L. Gialanella, E. Giorgio, S. R. Gozzini, R. Gracia, K. Graf, G. Grella, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, J. Haefner, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, S. Henry, J. J. Hernández-Rey, J. Hofestädt, F. Huang,W. Idrissi Ibnsalih, A. Ilioni, G. Illuminati, C.W. James, D. Janezashvili, P. Jansweijer, M. de Jong, P. de Jong, B. J. Jung, M. Kadler, P. Kalaczynski, O. Kalekin,U. F. Katz, F. Kayzel, P.Keller, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, M. Kreter, V. Kulikovskiy, M. Labalme, P. Lagier, R. Lahmann, P. Lamare, M. Lamoureux, G. Larosa, C. Lastoria, J. Laurence, A. Lazo, R. Le Breton, E. Le Guirriec, S. Le Stum, G. Lehaut, O. Leonardi, F. Leone, E. Leonora, C. Lerouvillois, J. Lesrel, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, C. LLorens Alvarez, A. Lonardo, F. Longhitano, D. Lopez-Coto, N. Lumb, L. Maderer, J. Majumdar, J. Manczak, A. Margiotta, A. Marinelli, A. Marini, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, K.W. Melis, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Mongelli, A. Moussa, R. Muller, P. Musico, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, M. O’Sullivan, A. Orlando, G. Ottonello, S. Ottonello, J. Palacios González5, G. Papalashvili, R. Papaleo, C. Pastore, A. M. Paun, G. E. Pavalas, G. Pellegrini, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, O. Pisanti, C. Poirè, V. Popa, T. Pradier, F. Pratolongo, I. Probst, G. Pühlhofer, S. Pulvirenti, G. Quéméner, N. Randazzo, A. Rapicavoli, S. Razzaque, D. Real, S. Reck, G. Riccobene, L. Rigalleau, A. Romanov, A. Rovelli, J. Royon, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, A. Santangelo, D. Santonocito, P. Sapienza, J. Schmelling, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, J. Steijger, S. M. Stellacci, M. Taiuti, F. Tatone, Y. Tayalati, E. Tenllado, D. Tézier, T. Thakore, S. Theraube, H. Thiersen, P. Timmer, S. Tingay, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, D. Tzanetatos, C. Valieri, V. Van Elewyck, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, G. de Wasseige, J.Wilms, R.Wojaczynski, E. deWolf, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, N. Zywucka.Postprint (published version

Real-time Multi-Messenger Analysis Framework of KM3NeT

KM3NeT is a multi-purpose cubic-kilometer neutrino observatory in construction in the Mediterranean Sea. It consists of ORCA and ARCA (for Oscillation and Astroparticle Research with Cosmics in the Abyss, respectively); currently both have a few detection lines in operation. Although having different primary goals, both detectors can be used to do neutrino astronomy over a wide energy range, from a few GeV to a few tens of PeV. In view of the growing field of time-domain astronomy, it is increasingly crucial to be able to identify neutrinos in real-time. This online neutrino sample will serve to trigger neutrino alerts that will be sent to the astronomy community and to look for time/space coincidence around external electromagnetic and multi-messenger triggers. These real-time searches can significantly increase the discovery potential of transient cosmic accelerators and refine the pointing directions in the case of poorly localized triggers, such as gravitational waves. In the field of core-collapse supernovae (CCSN), the detection of the MeVscale CCSN neutrinos is crucial as an early warning. KM3NeT’s digital optical modules act as good detectors for these neutrinos. This proceeding presents the status of KM3NeT’s real-time multi-messenger activities, including supernova monitoring, online event reconstruction, event classification and selection, alert distribution, and the first test of the selection on data.Article signat per 297 autors/es: M.Ageron, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulakis, M. Anghinolfi, M. Anguita, G. Anton, M. Ardid, S. Ardid, W. Assal, J. Aublin, C. Bagatelas, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A. M. van den Berg, V. Bertin, S. Beurthey, V. van Beveren, S. Biagi, M. Billault, M. Bissinger, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, C. Boutonnet, G. Bouvet, M. Bouwhuis, C. Bozza, H.Brânzas, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, L. Caillat, D. Calvo, S. Campion, A. Capone, H. Carduner, V. Carretero, P. Castaldi, S. Celli;, R. Cereseto, M. Chabab, C. Champion, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, S. Colonges, R. Coniglione, A. Cosquer, P. Coyle, M. Cresta, A. Creuso, A. Cruz, G. Cuttone, A. D’Amico, R. Dallier, B. De Martino, M. De Palma, I. Di Palma, A. F. Díaz, D. Diego- Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, H. Eljarrari, D. Elsaesser, A. Enzenhöfer, V. Espinosa, P. Fermani, G. Ferrara, M. D. Filipovic, F. Filippini, J. Fransen, L. A. Fusco, D. Gajanana, T. Gal, J. García Méndez, A. Garcia Soto, E. Garçon, F. Garufi, C. Gatius, N. Geißelbrecht, L. Gialanella, E. Giorgio, S. R. Gozzini, R. Gracia, K. Graf, G. Grella, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, J. Haefner, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, S. Henry, J. J. Hernández-Rey, J. Hofestädt, F. Huang,W. Idrissi Ibnsalih, A. Ilioni, G. Illuminati, C.W. James, D. Janezashvili, P. Jansweijer, M. de Jong, P. de Jong, B. J. Jung, M. Kadler, P. Kalaczynski, O. Kalekin,U. F. Katz, F. Kayzel, P.Keller, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, M. Kreter, V. Kulikovskiy, M. Labalme, P. Lagier, R. Lahmann, P. Lamare, M. Lamoureux, G. Larosa, C. Lastoria, J. Laurence, A. Lazo, R. Le Breton, E. Le Guirriec, S. Le Stum, G. Lehaut, O. Leonardi, F. Leone, E. Leonora, C. Lerouvillois, J. Lesrel, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, C. LLorens Alvarez, A. Lonardo, F. Longhitano, D. Lopez-Coto, N. Lumb, L. Maderer, J. Majumdar, J. Manczak, A. Margiotta, A. Marinelli, A. Marini, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, K.W. Melis, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Mongelli, A. Moussa, R. Muller, P. Musico, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, M. O’Sullivan, A. Orlando, G. Ottonello, S. Ottonello, J. Palacios González5, G. Papalashvili, R. Papaleo, C. Pastore, A. M. Paun, G. E. Pavalas, G. Pellegrini, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, O. Pisanti, C. Poirè, V. Popa, T. Pradier, F. Pratolongo, I. Probst, G. Pühlhofer, S. Pulvirenti, G. Quéméner, N. Randazzo, A. Rapicavoli, S. Razzaque, D. Real, S. Reck, G. Riccobene, L. Rigalleau, A. Romanov, A. Rovelli, J. Royon, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, A. Santangelo, D. Santonocito, P. Sapienza, J. Schmelling, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, J. Steijger, S. M. Stellacci, M. Taiuti, F. Tatone, Y. Tayalati, E. Tenllado, D. Tézier, T. Thakore, S. Theraube, H. Thiersen, P. Timmer, S. Tingay, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, D. Tzanetatos, C. Valieri, V. Van Elewyck, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, G. de Wasseige, J.Wilms, R.Wojaczynski, E. deWolf, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, N. Zywucka.Postprint (published version

Neutrino non-standard interactions with the KM3NeT/ORCA detector

KM3NeT/ORCA is a dense array that constitutes the low-energy branch of the KM3NeT project with the main goal of resolving the question of the neutrino mass ordering. At present, the KM3NeT/ORCA Phase 1 has already been deployed, which means that six out of the planned 115 detection lines are operational. Even with this limited configuration, neutrino oscillations can already be measured and studied. In this contribution, the sensitivity to the neutrino Non-Standard Interactions (NSI) parameter eµt using the current stage of the KM3NeT/ORCA detector together with the projections for the final configuration are presented.Postprint (published version

In Vivo

The aim of this study has been to visualize the aqueous outflow system in patients affected by primary open angle glaucoma. A solution of indocyanine green (ICG) plus high viscosity viscoelastic solution was injected into the Schlemm canal during surgery in 10 glaucomatous patients undergoing canaloplasty. Soon after injection of the dye the borders of the scleral flap were completely stained due to partial reflux caused by the intrachannel resistance; progression of the dye along the Schlemm canal starting from the site of injection was then visualized. The filling of the collector channels was observed only in the patent portions of the Schlemm canal. The only noticeable aqueous veins were located in correspondence of the quadrant in which both the Schlemm canal and the collectors were patent. Lastly, a retrograde filling, of glomerular-shaped structures, deepest to the Schlemm canal was observed in the quadrants where the pathway was functioning. Our findings show that injection of a mixture composed of ICG and viscoelastic solution into the Schlemm canal allows a clear visualization of the functioning portions of the conventional outflow pathway. In addition, a retrograde filling of structures presumably located into the iris was also recorded. Clinical Trial Registration. Our study is registered in ISRCTN registry, number 54005880, DOI 10.1186/ISRCTN54005880

Expectations for the high-energy neutrino detection from starburst galaxies with KM3NeT/ARCA

Star-forming galaxies (SFGs) and starburst galaxies (SBGs) are extragalactic sources which could produce high-energy neutrinos. In principle, they could play a rather important role for explaining at least a sizeable part of IceCube’s observations of astophysical neutrino. Using a recent theoretical model which implemented a blending of spectral indeces, we present the KM3NeT/ARCA sensitivities for such a diffuse flux from the startburst galaxies. In particular, we provide the 5-year differential sensitivity for the two building blocks of ARCA. We make use only of the track-like events in the range of 100 GeV - 10 PeV differentiate in 11 bins of energy. We show how the upcoming neutrino telescope could observe the diffuse SFG and SBG within 5 years of data taking. We found the minimum of the sensitivity at around 100 TeV, which is also the energy where the SBG contribution is expected to peak. This would not only constrain the multi-component fit of the observed astrophysical neutrino flux at that energy (100 TeV), but would also provide us a direct link between the star-forming activity in the reservoir environments and the hadronic emissions.Postprint (published version