Population health profile of the Northern Melbourne Division of General Practice

© Commonwealth of Australia To view the data presented in the profiles in Excel spreadsheets or via Interactive Mapping, please see the PHIDU website at: www.publichealth.gov.au

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons

Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process. A large body of data indicates that opioids and dopamine together mediate emotional and reinforced behaviors. In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of δ-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons. To further define cellular mechanisms underlying this effect, the subcellular distribution of DOR and D1R was examined in the rat dorsolateral striatum. Dual immunoperoxidase/gold-silver detection combined with electron microscopy was used to identify DOR and D1R immunoreactivities in the same section of tissue. Semi-quantitative analysis revealed that a subset of dendritic cellular profiles exhibited both DOR and D1R immunoreactivities. Of 165 randomly sampled D1R immunoreactive profiles, 43% contained DOR. Similarly of 198 DOR-labeled cellular profiles, 52% contained D1R. The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neurons, suggesting a possible mechanism whereby D1R modulation may alter DOR function

Influence of relative humidity on tensile and compressive creep of concrete amended with ground granulated blast-furnace slag

This paper presents an experimental study on the influence of ambient relative humidity on tensile creep of plain concrete amended with Ground Granulated Blast - furnace Slag and compares it with its influence on compressive creep. Tensile and compressive creep tests were carried out on concrete specimens of 34.49 MPa compressive strength and 0.56 water/binder ratio at 51, 68 and 100% relative humidity. The results show a linear relationship between compressive creep and relative humidity; this cannot be said about tensile creep. Tensile creep was observed to be more sensitive to change in ambient humidity than compressive creep. Based on equal applied stress, tensile creep was found to be several times higher than compressive creep and the difference was great er in drying creep than in basic creep. On the basis of equal stress/strength ratio, tensile - to - compressive creep ratio was slightly less than 1 for drying creep and much less for basic creep. Keywords: Compressive Creep, Concrete, Relative Humidity, Strain, Strength, Tensile Cree

Mathematical Modelling of Compressive Strength of Recycled Ceramic Tile Aggregate Concrete Using Modified Regression Theory

At present, the large quantity of wastes generated by the ceramic industry is not reused in any significant quantity. Research has shown the feasibility of incorporating these wastes into concrete production. This will benefit both the ceramic and concrete industries. However, not much research data is available on the use of ceramic wastes as fine aggregate material compared to their use as coarse aggregate material. Moreover, there are presently no models for predicting the properties of ceramic waste aggregate concretes. In this study, a modified regression theory based on Taylor’s series was adopted to formulate mathematical model for predicting compressive strength of concrete into which Recycled Ceramic Tile (RCT) is incorporated as fine aggregate.  Preliminary tests on RCT indicate that it is a suitable fine aggregate material for concrete production. It has also been established that addition of RCT improves compressive strength of concrete and reduces concrete’s workability. The formulated model is a function of the mix proportions of its constituents and its predicted responses are in good agreement with experimentally observed data. The model has been tested using student’s t-test and analysis of variance and has been confirmed to be adequate and hence is validated

Uptake of 3,4-dihydroxy[3H]phenylalanine by Mycobacterium leprae isolated from frozen (-80 °C) armadillo tissue

Mycobacterium leprae separated from armadillo tissues stored at -80 °C is similar to that from human sources in its ability to take up 3H-labelled 3,4-dihydroxyphenylalanine (DOPA). Several inhibitors were studied which showed complete or partial inhibition of [3H]DOPA uptake. These findings suggest that M. leprae isolated from frozen tissue possesses an active uptake system for [3H]DOPA

Population health profile of the Northern Sydney Division of General Practice

© Commonwealth of Australia To view the data presented in the profiles in Excel spreadsheets or via Interactive Mapping, please see the PHIDU website at: www.publichealth.gov.au