20 research outputs found
What is the most effective treatment for nocturia or nocturnal incontinence in adult women?
Acknowledgments The authors express their thanks to F.C. Burkhard for invaluable logistic support during the conception of the manuscript.Peer reviewedPostprin
Human papillomavirus infection and intrauterine growth restriction: a data-linkage study
Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy.
BACKGROUND AND AIMS
The effects of protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on endothelial function as assessed by flow-mediated dilation (FMD) in patients with acute myocardial infarction (AMI) are unknown. Therefore, we aimed to investigate the effects of the PCSK9 inhibitor alirocumab added to high-intensity statin on FMD, and its association with coronary atherosclerosis in non-infarct related arteries using intracoronary intravascular ultrasound (IVUS), near-infrared spectroscopy (NIRS), and optical coherence tomography (OCT).
METHODS
This was a pre-specified substudy among patients recruited at Bern University Hospital, Switzerland, for the randomized-controlled, double-blind, PACMAN-AMI trial, which compared the effects of biweekly alirocumab 150Â mg vs. placebo added to rosuvastatin. Brachial artery FMD was measured at 4 and 52 weeks, and intracoronary imaging at baseline and 52 weeks.
RESULTS
139/173 patients completed the substudy. There was no difference in FMD at 52 weeks in the alirocumab (n = 68, 5.44 ± 2.24%) versus placebo (n = 71, 5.45 ± 2.19%) group (difference = -0.21%, 95% CI -0.77 to 0.35, p = 0.47). FMD improved throughout 52 weeks in both groups similarly (p < 0.001). There was a significant association between 4 weeks FMD and baseline plaque burden (IVUS) (n = 139, slope = -1.00, p = 0.006), but not with lipid pool (NIRS) (n = 139, slope = -7.36, p = 0.32), or fibrous cap thickness (OCT) (n = 81, slope = -1.57, p = 0.62).
CONCLUSIONS
Among patients with AMI, the addition of alirocumab did not result in further improvement of FMD as compared to 52 weeks secondary preventative medical therapy including high-intensity statin therapy. FMD was significantly associated with coronary plaque burden at baseline, but not with lipid pool or fibrous cap thickness
CH-Impacts. Klimaszenarien CH2018 und daraus abgeleitete Folgen fĂŒr die Schweiz â wie weiter? Grundlagenbericht des Vorprojekts
EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence
CONTEXT
The European Association of Urology guidelines on urinary incontinence (UI) have been updated in cyclical fashion with successive major chapters being revised each year. The sections on assessment, diagnosis, and nonsurgical treatment have been updated as of mid-2016.
OBJECTIVE
We present a condensed version of the full guideline on assessment and nonsurgical management of UI, with the aim of improving accessibility and increasing their dissemination.
EVIDENCE ACQUISITION
Our literature search was updated from the previous cut-off of July 2010 up to April 2016. Evidence synthesis was carried out by a pragmatic review of current systematic reviews and any newer subsequent high-quality studies, based on Population, Interevention, Comparator, and Outcome questions. Appraisal was conducted by an international panel of experts, working on a strictly nonprofit and voluntary basis, to develop concise evidence statements and action-based recommendations using modified Oxford and GRADE criteria.
EVIDENCE SYNTHESIS
The guidelines include algorithms that summarise the suggested pathway for standard, uncomplicated patients with UI and are more useable in daily practice. The full version of the guideline is available at http://uroweb.org/guideline/urinary-incontinence/.
CONCLUSIONS
These updated guidelines provide an evidence-based summary of the assessment and nonsurgical management of UI, together with a clear clinical algorithm and action-based recommendations. Although these guidelines are applicable to a standard patient, it must be remembered that therapy should always be tailored to individual patients' needs and circumstances.
PATIENT SUMMARY
Urinary incontinence is a very common condition which negatively impacts patient's quality of life. Several types of incontinence exist and since the treatments will vary, it is important that the diagnostic evaluation establishes which type is present. The diagnosis should also identify patients who need rapid referral to an appropriate specialist. These guidelines aim to provide sensible and practical evidence-based guidance on the clinical problem of urinary incontinence
EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence
CONTEXT
The European Association of Urology guidelines on urinary incontinence (UI) have been updated in cyclical fashion with successive major chapters being revised each year. The sections on assessment, diagnosis, and nonsurgical treatment have been updated as of mid-2016.
OBJECTIVE
We present a condensed version of the full guideline on assessment and nonsurgical management of UI, with the aim of improving accessibility and increasing their dissemination.
EVIDENCE ACQUISITION
Our literature search was updated from the previous cut-off of July 2010 up to April 2016. Evidence synthesis was carried out by a pragmatic review of current systematic reviews and any newer subsequent high-quality studies, based on Population, Interevention, Comparator, and Outcome questions. Appraisal was conducted by an international panel of experts, working on a strictly nonprofit and voluntary basis, to develop concise evidence statements and action-based recommendations using modified Oxford and GRADE criteria.
EVIDENCE SYNTHESIS
The guidelines include algorithms that summarise the suggested pathway for standard, uncomplicated patients with UI and are more useable in daily practice. The full version of the guideline is available at http://uroweb.org/guideline/urinary-incontinence/.
CONCLUSIONS
These updated guidelines provide an evidence-based summary of the assessment and nonsurgical management of UI, together with a clear clinical algorithm and action-based recommendations. Although these guidelines are applicable to a standard patient, it must be remembered that therapy should always be tailored to individual patients' needs and circumstances.
PATIENT SUMMARY
Urinary incontinence is a very common condition which negatively impacts patient's quality of life. Several types of incontinence exist and since the treatments will vary, it is important that the diagnostic evaluation establishes which type is present. The diagnosis should also identify patients who need rapid referral to an appropriate specialist. These guidelines aim to provide sensible and practical evidence-based guidance on the clinical problem of urinary incontinence
Derandomizing random walks in undirected graphs using locally fair exploration strategies
La guerre en Normandie (XIe-XVe siÚcle)
Le 13 aoĂ»t 1415, lâarmĂ©e dâHenri V, roi dâAngleterre, se prĂ©senta devant Chef-de-Caux, prit Harfleur au terme dâun siĂšge de six semaines, puis rencontra Ă Azincourt lâarmĂ©e française quâelle mit en piĂšces. LâexpĂ©dition marqua le dĂ©but dâune pĂ©riode de conflit intense en Normandie, oĂč la guerre nâavait en rĂ©alitĂ© rien de nouveau. En effet, lâidentitĂ© du duchĂ© fut forgĂ©e dans la guerre et lâouvrage, nĂ© dâun colloque tenu Ă Cerisy-la-Salle, interroge sur une maniĂšre de faire la guerre qui pourrait ĂȘtre propre aux Normands en proposant de questionner lâimpact de la guerre sur la sociĂ©tĂ© et lâĂ©conomie, les rĂ©cits de guerre et la mĂ©moire de la guerre entre le XIe et le XVe siĂšcle