17 research outputs found

    Tackling water and food crisis in South Asia: Insights from the Indo-Gangetic Basin

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    CPWF-IWMI “Basin Focal Project for the Indus-Gangetic Basin” is an initiative by the CPWF, to identify steps to be taken towards integrated management of the IGB’s water and land resources to improve productivity and ensure future sustainability of all production and ecosystems in the basin. The project was developed with the objective of conducting basin-wide analysis of the conditions, constraints and opportunities for improving agricultural water productivity and alleviating poverty through high potential interventions. This objective was accomplished through rigorous analysis and mapping of water availability and access, poverty, and productivity of water and identifying potential interventions that contribute to improved water productivity and poverty alleviation in the Indo-Gangetic basin

    Taxonomy of the order Mononegavirales: update 2016

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    In 2016, the order Mononegavirales was emended through the addition of two new families (Mymonaviridae and Sunviridae), the elevation of the paramyxoviral subfamily Pneumovirinae to family status (Pneumoviridae), the addition of five free-floating genera (Anphevirus, Arlivirus, Chengtivirus, Crustavirus, and Wastrivirus), and several other changes at the genus and species levels. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV)

    Water-land-poverty nexus in the Indo-Gangetic Basin

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    In Sharma, Bharat R.; Amarasinghe, Upali; Ambili, G. K. (Eds). Tackling water and food crisis in South Asia: insights from the Indo-Gangetic Basin. Synthesis report of the Basin Focal Project for the Indo-Gangetic Basin. Colombo, Sri Lanka: CGIAR Challenge Program on Water and Food (CPWF

    The Indus and the Ganges: river basins under extreme pressure.

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    The basins of the Indus and Ganges rivers cover 2.20 million km2 and are inhabited by more than a billion people. The region is under extreme pressures of population and poverty, unregulated utilization of the resources and low levels of productivity. The needs are: (1) development policies that are regionally differentiated to ensure resource sustainability and high productivity; (2) immediate development and implementation of policies for sound groundwater management and energy use; (3) improvement of the fragile food security and to broaden its base; and (4) policy changes to address land fragmentation and improved infrastructure. Meeting these needs will help to improve productivity, reduce rural poverty and improve overall human development

    The Indus and the Ganges: river basins under extreme pressure

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    In Fisher, M.; Cook, Simon (Eds.). Water, food and poverty in river basins: defining the limits. London, UK: Routledg

    Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

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    Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1. Pgam5(-/-) mice showed exacerbated lung inflammation and proinflammatory cytokines in an ozone-exposure model. Similarly, challenge with influenza A virus led to increased infiltration of the virus, lymphocytic bronchiolitis and reduced survival of Pgam5(-/-) mice. This pathway, which we have called 'oxeiptosis', was a ROS-sensitive, caspase independent, non-inflammatory cell-death pathway and was important for protection against inflammation induced by ROS or ROS-generating agents such as viral pathogens
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