Galaxy And Mass Assembly (GAMA): linking star formation histories and stellar mass growth

We present evidence for stochastic star formation histories in low-mass (M* < 1010 M⊙) galaxies from observations within the Galaxy And Mass Assembly (GAMA) survey. For ˜73 000 galaxies between 0.05 < z < 0.32, we calculate star formation rates (SFR) and specific star formation rates (SSFR = SFR/M*) from spectroscopic Hα measurements and apply dust corrections derived from Balmer decrements. We find a dependence of SSFR on stellar mass, such that SSFRs decrease with increasing stellar mass for star-forming galaxies, and for the full sample, SSFRs decrease as a stronger function of stellar mass. We use simple parametrizations of exponentially declining star formation histories to investigate the dependence on stellar mass of the star formation time-scale and the formation redshift. We find that parametrizations previously fit to samples of z ˜ 1 galaxies cannot recover the distributions of SSFRs and stellar masses observed in the GAMA sample between 0.05 < z < 0.32. In particular, a large number of low-mass (M* < 1010 M⊙) galaxies are observed to have much higher SSFRs than can be explained by these simple models over the redshift range of 0.05 < z < 0.32, even when invoking mass-dependent staged evolution. For such a large number of galaxies to maintain low stellar masses, yet harbour such high SSFRs, requires the late onset of a weak underlying exponentially declining star formation history with stochastic bursts of star formation superimposed

Star Formation in a Stellar Mass Selected Sample of Galaxies to z=3 from the GOODS NICMOS Survey (GNS)

We present a study of the star-forming properties of a stellar mass-selected sample of galaxies in the GOODS NICMOS Survey (GNS), based on deep Hubble Space Telescope imaging of the GOODS North and South fields. Using a stellar mass selected sample, combined with HST/ACS and Spitzer data to measure both UV and infrared derived star formation rates (SFR), we investigate the star forming properties of a complete sample of ~1300 galaxies down to log M*=9.5 at redshifts 1.5<z<3. Eight percent of the sample is made up of massive galaxies with M*>10^11 Msun. We derive optical colours, dust extinctions, and ultraviolet and infrared SFR to determine how the star formation rate changes as a function of both stellar mass and time. Our results show that SFR increases at higher stellar mass such that massive galaxies nearly double their stellar mass from star formation alone over the redshift range studied, but the average value of SFR for a given stellar mass remains constant over this 2 Gyr period. Furthermore, we find no strong evolution in the SFR for our sample as a function of mass over our redshift range of interest, in particular we do not find a decline in the SFR among massive galaxies, as is seen at z < 1. The most massive galaxies in our sample (log M*>11) have high average SFRs with values, SFR(UV,corr) = 103+/-75 Msun/yr, yet exhibit red rest-frame (U-B) colours at all redshifts. We conclude that the majority of these red high-redshift massive galaxies are red due to dust extinction. We find that A(2800) increases with stellar mass, and show that between 45% and 85% of massive galaxies harbour dusty star formation. These results show that even just a few Gyr after the first galaxies appear, there are strong relations between the global physical properties of galaxies, driven by stellar mass or another underlying feature of galaxies strongly related to the stellar mass.Comment: 18 pages, 10 figures, accepted for publication in MNRA

Glycemic Variability Predicts Inflammation in Adolescents with Type 1 Diabetes

Background: Adolescents with type 1 diabetes (T1D) have increased risk of cardiovascular disease as well as elevations in biomarkers of systemic inflammation, plasma protein oxidation and vascular endothelial injury. It is unclear whether hyperglycemia itself, or variations in blood glucose are predictors of these abnormalities. Methods: This study was designed to determine the relationship of inflammatory (C-reactive protein, CRP), oxidative (total anti-oxidative capacity, TAOC) and endothelial injury (soluble intracellular adhesion molecule 1, sICAM1) markers to glycemic control measures from 3 days of continuous glucose monitoring (CGM) and to hemoglobin A1c (HbA1c), and HbA1c×duration area under the curve (A1cDur). Results: Seventeen adolescents (8 F/9M; age, 13.1±1.6 years (mean±SD); duration, 4.8±3.8 years, BMI, 20.3±3.1 kg/m2; A1c, 8.3±1.2%) were studied. Log CRP but was not related to age, duration, body mass index (BMI), HbA1c, or A1cDUR. TAOC increased as logA1cDUR increased (n=13, r=0.61, p=0.028). CRP and sICAM were not related to CGM average glucose but log CRP increased as 3 day glucose standard deviation increased (r=0.66, p=0.006). TAOC increased as glucose standard deviation increased (r=0.63, p=0.028). Conclusions: Increased glucose variability is associated with increased inflammation in adolescents withT1D. Increased TAOC with increasing variability may be an effort to compensate for the ongoing oxidative stress

Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes

Alterations of blood flow and endothelial function precede development of complications in type 1 diabetes. The effects of hyperglycemia on vascular function in early type 1 diabetes are poorly understood. To investigate the effect of hyperglycemia on forearm vascular resistance (FVR) and endothelial function in adolescents with type 1 diabetes, FVR was measured before and after 5 minutes of upper arm arterial occlusion using venous occlusion plethysmography in (1) fasted state, (2) euglycemic state (~90 mg/dL; using 40 mU/m2/min insulin infusion), and (3) hyperglycemic state (~200 mg/dL) in 11 adolescents with type 1 diabetes. Endothelial function was assessed by the change in FVR following occlusion. Seven subjects returned for a repeat study with hyperglycemia replaced by euglycemia. Preocclusion FVR decreased from euglycemia to hyperglycemia (P = 0.003). Postocclusion fall in FVR during hyperglycemia was less than during euglycemia (P = 0.002). These findings were not reproduced when hyperglycemia was replaced with a second euglycemia. These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes. In addition they have implications for future studies of endothelial function in type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes

Unproceedings of the Fourth .Astronomy Conference (.Astronomy 4), Heidelberg, Germany, July 9-11 2012

The goal of the .Astronomy conference series is to bring together astronomers, educators, developers and others interested in using the Internet as a medium for astronomy. Attendance at the event is limited to approximately 50 participants, and days are split into mornings of scheduled talks, followed by 'unconference' afternoons, where sessions are defined by participants during the course of the event. Participants in unconference sessions are discouraged from formal presentations, with discussion, workshop-style formats or informal practical tutorials encouraged. The conference also designates one day as a 'hack day', in which attendees collaborate in groups on day-long projects for presentation the following morning. These hacks are often a way of concentrating effort, learning new skills, and exploring ideas in a practical fashion. The emphasis on informal, focused interaction makes recording proceedings more difficult than for a normal meeting. While the first .Astronomy conference is preserved formally in a book, more recent iterations are not documented. We therefore, in the spirit of .Astronomy, report 'unproceedings' from .Astronomy 4, which was held in Heidelberg in July 2012.Comment: 11 pages, 1 figure, .Astronomy 4, #dotastr

Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03)

Purpose: Malnutrition in head and neck cancer (HNC) treatment is common and associated with poorer morbidity and mortality outcomes. This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians to deliver psychological techniques to improve nutritional behaviors in patients with HNC. Methods and Materials: This trial used a stepped-wedge, randomized controlled design to assess the efficacy of the Eating As Treatment (EAT) program. Based on motivational interviewing and cognitive behavioral therapy, EAT was designed to be delivered by oncology dietitians and integrated into their clinical practice. During control steps, dietitians provided treatment as usual, before being trained in EAT and moving into the intervention phase. The training was principles based and sought to improve behavior-change skills rather than provide specific scripts. Patients recruited to the trial (151 controls, 156 intervention) were assessed at 4 time points (the first and the final weeks of RT, and 4 and 12 weeks afterward). The primary outcome was nutritional status at the end of RT as measured by the Patient-Generated Subjective Global Assessment. Results: Patients who received the EAT intervention had significantly better scores on the primary outcome of nutritional status at the critical end-of-treatment time point (β = −1.53 [−2.93 to −.13], P =.03). Intervention patients were also significantly more likely than control patients to be assessed as well-nourished at each time point, lose a smaller percentage of weight, have fewer treatment interruptions, present lower depression scores, and report a higher quality of life. Although results were not statistically significant, patients who received the intervention had fewer and shorter unplanned hospital admissions. Conclusions: This trial is the first of its kind to demonstrate the effectiveness of a psychological intervention to improve nutrition in patients with HNC who are receiving RT. The intervention provides a means to ameliorate malnutrition and the important related outcomes and consequently should be incorporated into standard care for patients receiving RT for HNC

Creating a Culture of Mentoring @ Your Library

The need to find and retain high quality leadership for libraries is one of the top seven issues for academic libraries. With a significant percentage of librarians planning to retire in the next decade, retaining professionals is imperative. Librarians must not only be retained, but mentored and developed for future leadership roles in the academic library community (Hisle, 2002). Creating a “culture of mentoring” helps the organization, individuals in the organization, and those with whom they interact. This culture provides integrity (accountability) throughout the organization, and opportunities for learning, for feedback and for improvement of performance throughout the organization. Libraries are using mentoring to orient new librarians, to assist them through the promotion and tenure process, and to provide information to librarians interested in advancement