Is Aphtous Oral Ulceration Biopsy always Useless?

Objective: To report a case of Behçet’s disease whose diagnosis was only confirmed thanks to an oral aphthous lesion biopsy. Materials and methods: Conventional histopathological analysis of a biopsy of an aphthous oral lesion that had appeared two days previously. Results: A small vein vasculitis with eosinophil and neutrophil granulocytes was evidenced. Conclusion: The presence of a small vein vasculitis was here strongly in favour of Behçet's disease, whereas such a diagnosis was not confirmed according to the International Study Group’s criteria

Angioedèmes bradykiniques : à propos de 34 cas en Champagne-Ardennes

REIMS-BU Santé (514542104) / SudocSudocFranceF

Utilisation des thérapies complémentaires par des patients traités par immunoglobulines dans le cadre des déficits immunitaires primitifs

REIMS-BU Santé (514542104) / SudocSudocFranceF

Rôle et connaissances des médecins généralistes dans la prise en charge de l'HTAP en Champagne-Ardenne

REIMS-BU Santé (514542104) / SudocSudocFranceF

Etude des patients adultes hospitalisés pour suspiscion de grippe A (H1N1) 2009 au CHU de Reims pendant la pandémie de 2009

REIMS-BU Santé (514542104) / SudocSudocFranceF

Cytomegalovirus associated hemophagocytic lymphohistiocytosis in patients suffering from crohnʼs disease treated by azathioprine: A series of four cases

International audienc

Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?

International audienceRationale: Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) has rarely been reported.Patient concerns: We report here 2 cases of this association.Diagnoses: The first case involves a 32-year-old woman who developed, 1 year after SLE diagnosis, 3 painful nodular lesions of PG on her face, and cervical area. The second case was observed in a 37-year-old woman referred for ulcerative nodular papules of PG on her legs, whereas she had been diagnosed with SLE 10 years before. SLE was inactive in the first case, whereas PG occurred during a lupus flare up in the second one.Interventions: We found 23 previous cases of SLE and PG in the literature with most cases (12/20) occurring during a lupus flare.Outcomes: Although rare, this association may be supported by common innate immunity dysregulation and abnormal neutrophil activation.Lessons: PG and other neutrophilic diseases reported in patients with SLE may be added to the large clinical spectrum of cutaneous lesions observed in SLE

Takayasu arteritis revealed by unusual cutaneous manifestations

International audienc