Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer

Background:There is a large degree of variation in tumour response and host toxicities associated with neoadjuvant chemoradiation for rectal cancer patients. We performed a complimentary pharmacogenetic study to investigate germline polymorphisms of genes involved in 5-fluorouracil (5-FU) and irinotecan pathways and their potential association with clinical outcomes and toxicities from neoadjuvant chemoradiation in patients with rectal cancer treated in a prospective genotype-directed study.Methods:The germline DNA of 131 patients was genotyped for 10 variants in TYMS, MTHFR, DPYD, UGT1A1, ABCC1 and SLCO1B1 genes. Ninety-six patients were treated with 5-FU/radiotherapy (RT) and 35 received 5-FU/RT/irinotecan. Relationships between genetic variants and adverse events, tumour response, overall and disease-free survivals were assessed.Results:MTHFR 1298A>C and MTHFR diplotypes (for 677C>T and 1298A>C) were associated with chemoradiation-related toxicity when 5-FU was used alone. MTHFR haplotypes (677C–1298C) and diplotypes (CA–TA and TA–TA) showed, respectively, a protective and a negative effect on the incidence of severe diarrhoea or mucositis. No association was observed between genetic markers and drug response.Conclusion:MTHFR polymorphisms can potentially predict toxicity in patients treated with 5-FU as a single chemotherapeutic drug

Polymer-based 3-D printed Ku-band steerable phased-array antenna subsystem

This paper introduces the first fully 3-D printed tunable microwave subsystem, consisting of 26 circuit elements. Here, a polymer-based 3-D printed Ku-band 4-element steerable phased-array antenna with fully integrated beam forming network is demonstrated. Polyjet was adopted for fabricating the main body of the subsystem, as it is capable of producing a geometrically complex structure with high resolution over a large volume. Low-cost fused deposition modeling was chosen to manufacture the dielectric inserts and brackets for the phase shifters. The measured radiation pattern revealed that the phased-array antenna subsystem has total beam steering angles of 54° and 52° at 15 GHz and 17 GHz, respectively. Excellent input return loss behavior was observed across the optimum operational frequency range of 15 to 17 GHz; with a worst-case measured return loss of 12.9 dB. This work clearly shows the potential of using 3-D printing technologies for manufacturing fully integrated subsystems with complex geometric features

Correction: Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies (Critical Care, (2023), 27, 1, (3), 10.1186/s13054-022-04294-5)

Following publication of the original article [1], the authors identified that the collaborating authors part of the collaborating author group CCCC Consortium was missing. The collaborating author group is available and included as Additional file 1 in this article