An Empirical Investigation of Personal Characteristics Significantly Affecting Employment Offers from International Accounting Firms to Accounting Graduates

The basis for this study was the desire of many accounting students to gain employment with international accounting firms and to know which personal characteristics affect employment offers. Some issues addressed by this thesis follow. (1) What student characteristics had significant effects on employment offers? (2) What were significant differences in characteristics of female/male students receiving offers? (3) What were significant differences in successful/unsuccessful male students? Female students? (4) Which characteristics were important predictors of salary-offer size? (5) Were reasons for selecting accounting careers related to receiving employment offers? (6) Was there discrimination because of sex regarding employment offers? (7) What were successful students* opinions regarding their communication skills? Interviewing ability? Willingness to travel? (8) How many campus interviews, office visits, and employment offers were received by successful students? The characteristics considered were identified by review of the interviewing process, candidate evaluation forms, and completed recruitment files. A questionnaire measuring these characteristics was completed by 187 students from nine universities. Discriminant analysis, multiple regression, and Chi-square tests were employed to reach the following findings. (1) Successful/unsuccessful students differed in regard to accounting grade-point averages, ease of interviewing, and Beta Alpha Psi membership. (2) Successful females had more accounting experience and positions in organizations than successful males; successful males had poorer English grades but more miscellaneous financial support for college expenses than successful females. (3) Successful males were more likely to be members of Beta Alpha Psi, raise intense interview questions, possess another undergraduate degree, and be younger than unsuccessful males. Successful females had better accounting/English grades, more financial support for college expenses, and more attractive appearances than unsuccessful ones. (4) Positive factors related to salary size included the accounting grade-point average, Beta Alpha Psi membership, communication initiative during interviews, positions in organizations, and another undergraduate degree. (5) Employment offers were unrelated to reasons for career choice. (6) No discrimination because of sex was noted. (7) Successful students ranked themselves higher in communication/ interviewing skills; unsuccessful students in travel willingness. (8) Successful students averaged approximately six campus interviews, four office visits, and three employment offer

Valedictory Address: John Alvis

Valedictory Address given by John Alvis in the Spring of 1966

MARKETING MIX PARA INCREMENTAR LAS VENTAS DE LA EMPRESA ESTACIÓN DE SERVICIOS EL CARIBE S.A.C. CHICLAYO 2017

La investigación tuvo como objetivo, determinar el marketing mix para incrementar las ventas de la empresa Estación de Servicios “El Caribe” S.A.C La metodología se basó en un estudio de tipo descriptivo con un diseño no experimental, transversal, donde se ha considerado como muestra a los 148 clientes de la empresa Estación de Servicios el Caribe S.A.C. Los resultados mostraron que, los factores que se utilizan para la aplicación del marketing mix en la empresa Estación de Servicios el Caribe S.A.C son, la variedad de los precios, la importancia del uso de la página web y las ofertas que se realizan para los clientes, así mismo se determinó que el medio que más se utiliza para difundir información es el volante. Además, que la atención que brinda los trabajadores a los clientes se efectúa de una manera eficiente. Sin embargo, aún falta afianzar ciertos indicadores para una excelente atención al cliente. Se concluye, que la aplicación de estrategias de marketing mix en la empresa permitirá el incremento en las ventas, como también mejorar el posicionamiento de la empresa en el mercado.Tesi

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome. Investigation of mammalian transcriptome divergence has been restricted to analysis of bulk gene expression levels and gene-internal splicing. Using allele-specific expression analysis in inter-strain hybrids of Mus musculus, we determined the contribution of multiple cellular regulatory systems to transcriptome divergence, including: alternative promoter usage, transcription start site selection, cassette exon usage, alternative last exon usage, and alternative polyadenylation site choice. Between mouse strains, a fifth of genes have variations in isoform usage that contribute to transcriptomic changes, half of which alter encoded amino acid sequence. Virtually all divergence in isoform usage altered the post-transcriptional regulatory instructions in gene UTRs. Furthermore, most genes with isoform differences between strains contain changes originating from multiple regulatory systems. This result indicates widespread cross-talk and coordination exists among different regulatory systems. Overall, isoform usage diverges in parallel with and independently to gene expression evolution, and the cis and trans regulatory contribution to each differs significantly

Phase 1 study of Intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection

Background: Enadenotucirev (formerly ColoAd1) is a tumor-selective chimeric adenovirus with demonstrated preclinical activity. This phase 1 Mechanism of Action study assessed intravenous (IV) delivery of enadenotucirev in patients with resectable colorectal cancer (CRC), non-small-cell lung cancer (NSCLC), urothelial cell cancer (UCC), and renal cell cancer (RCC) with a comparator intratumoral (IT) dosed CRC patient cohort. Methods: seventeen patients scheduled for primary tumor resection were enrolled. IT injection of enadenotucirev (CRC only) was administered as a single dose (≤ 3 × 1011 viral particles [vp]) on day 1, followed by resection during days 8-15. IV infusion of enadenotucirev was administered by three separate doses (1 × 1012 vp) on days 1, 3, and 5, followed by resection during days 8-15 (CRC) or days 10-25 (NSCLC, UCC, and RCC). Enadenotucirev activity was measured using immunohistochemical staining of nuclear viral hexon and quantitative polymerase chain reaction for viral genomic DNA. Results: delivery of enadenotucirev was observed in most tumor samples following IV infusion, with little or no demonstrable activity in normal tissue. This virus delivery (by both IV and IT dosing) was accompanied by high local CD8+ cell infiltration in 80% of tested tumor samples, suggesting a potential enadenotucirev-driven immune response. Both methods of enadenotucirev delivery were well tolerated, with no treatment-associated serious adverse events. Conclusions: this study provides key delivery and feasibility data to support the use of IV infusion of enadenotucirev, or therapeutic transgene-bearing derivatives of it, in clinical trials across a range of epithelial tumors, including the ongoing combination study of enadenotucirev with the checkpoint inhibitor nivolumab. It also provides insights into the potential immune-stimulating properties of enadenotucirev. Trial registration: this MOA study was a phase 1, multicenter, non-randomized, open-label study to investigate the administration of enadenotucirev in a preoperative setting (ClinicalTrials.gov: NCT02053220)

Submission of Microarray Data to Public Repositories

The Microarray Gene Expression Data Society believe that the time is right for journals to require that microarray data be deposited in public repositories, as a condition for publicatio