Probing High Frequency Noise with Macroscopic Resonant Tunneling

We have developed a method for extracting the high-frequency noise spectral density of an rf-SQUID flux qubit from macroscopic resonant tunneling (MRT) rate measurements. The extracted noise spectral density is consistent with that of an ohmic environment up to frequencies ~ 4 GHz. We have also derived an expression for the MRT lineshape expected for a noise spectral density consisting of such a broadband ohmic component and an additional strongly peaked low-frequency component. This hybrid model provides an excellent fit to experimental data across a range of tunneling amplitudes and temperatures

Poly[(μ3-biphenyl-3,3′-dicarboxyl­ato)(1,10-phenanthroline)cadmium]

In the title compound, [Cd(C14H8O4)(C12H8N2)]n, the CdII ion is seven-coordinated in a distorted penta­gonal–bipyramidal coordination geometry by five O atoms from bridging biphenyl-3,3′-dicarboylate (dpda) ligands and two N atoms from a 1,10-phenanthroline (1,10-phen) ligand. In the crystal, dinuclear units with a Cd⋯Cd separation of 3.8208 (7) Å are observed. Each of these dinuclear units is bridged via 3,3′-bpda in a chelating/chelating and bridging fashion, generating a zigzag chain along the c axis. Neighboring chains are further packed via weak π–π inter­actions between inter­chain parallel 1,10-phen rings [centroid–centroid distance = 3.5197 (9) Å] into a three-dimensional supra­molecular architecture

Bis(thio­cyanato-κN)[tris­(2-pyridylmeth­yl)amine-κ4 N,N′,N′′,N′′′]nickel(II) methanol hemisolvate

The title complex, [Ni(NCS)2(C18H18N4)]·0.5CH3OH, consists of two crystallographically distinct complexes and a methanol solvent mol­ecule. The NiII complexes are pseudo-octa­hedral six-coordinate, with the tris­(2-pyridylmeth­yl)amine (TPA) ligand providing four N atoms and two N-bound thio­cyanates providing the final two N atoms. The distances and angles are typical for NiII–TPA complexes. The compound has unit-cell parameters that are surprisingly similar to the previously reported hydrate

bullous wells syndrome associated with non hodgkin s lymphocytic lymphoma

3/µl; eosinophils 14.3% neutrophils 48%, lymphocytes 31.2%, monocytes 6.5%, basophils 0.2%), total immunoglobulin E (IgE) = 751 IU/ml, C-reactive protein (CRP) 1.25 mg/dl, erythrocyte sedimentation rate (ESR) in the first hour 60 mm; viral markers (Epstein Barr virus, cytomegalovirus, hepatitis A, B and C virus), cryoglobulin, ANCA, LAC, ANA, ENA and anti-DNA antibodies were all negative. Histopathological examination of the lesion on the left leg showed an epidermis characterized by multiple, sometimes confluent vesicles containing serum and eosinophil granulocytes. The underlying papillary dermis was markedly oedematous, with focal and minimal erythrocytic extravasations and an interstitial eosinophil granulocytic infiltrate. The reticular dermis was infiltrated by a large number of prevalently perivascular lymphocytic elements and numerous perivascular and interstitial eosinophil granulocytes, which also extended along the interlobular hypodermal septa and, to a lesser extent, the hypodermic lobules. The reticular dermis also showed some small and isolated flame figures (Fig. 2). The diagnosis of Wells' syndrome was made on the basis of the clinical picture and the histological findings, together with a negative direct immunofluorescence test (5). Having excluded pharmacological, infective, vasculitic and inflammatory causes, the subsequent instrumental and laboratory investigations were aimed at identifying a possible relapse of the patient's previous neoplastic disease. Complete abdominal ultrasonography, chest radiography and colonoscopy were negative, as was a search for tumour markers. The physical examination findings of numerous swollen inguinal and axillary lymph nodes therefore drew our attention to a possible underlying lymphoproliferative disease, and a subsequent lymph node biopsy revealed a picture compatible with a diffuse, small-cell non-Hodgkin's B lymphoma/ B-cell CLL, which was confirmed by a bone marrow biopsy

Dewetting of PtCu Nanoalloys on TiO2 Nanocavities Provides a Synergistic Photocatalytic Enhancement for Efficient H2 Evolution

We investigate the co-catalytic activity of PtCu alloy nanoparticles for photocatalytic H2 evolution from methanol-water solutions. To produce the photocatalysts, a few nm-thick Pt-Cu bilayers are deposited on anodic TiO2 nanocavity arrays and converted by solid state dewetting, i.e. a suitable thermal treatment, into bimetallic PtCu nanoparticles. XRD and XPS results prove the formation of PtCu nanoalloys that carry a shell of surface oxides. XANES data support Pt and Cu alloying and indicate the presence of lattice disorder in the PtCu nanoparticles. The PtCu co-catalyst on TiO2 shows a synergistic activity enhancement and a significantly higher activity towards photocatalytic H2 evolution than Pt- or Cu-TiO2. We propose the enhanced activity to be due to Pt-Cu electronic interactions, where Cu increases the electron density on Pt favoring a more efficient electron transfer for H2 evolution. In addition, Cu can further promote the photo-activity by providing additional surface catalytic sites for hydrogen recombination. Remarkably, when increasing the methanol concentration up to 50 vol% in the reaction phase, we observe for PtCu-TiO2 a steeper activity increase compared to Pt-TiO2. A further increase in methanol concentration (up to 80 vol%) causes for Pt-TiO2 a clear activity decay, while PtCu-TiO2 still maintains a high level of activity. This suggests an improved robustness of PtCu nanoalloys against poisoning from methanol oxidation products such as CO

Selective Protein Conjugation of Poly(glycerol monomethacrylate) and Poly(polyethylene glycol methacrylate) with Tunable Topology via Reductive Amination with Multifunctional ATRP Initiators for Activity Preservation

In this study, we compare poly(glycerol monomethacrylate) (PGMA) of different chain lengths and architectures (linear and two-arm) with poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) as an alternative polymer platform for the synthesis of a new generation of protein-polymer conjugates. Mono-and two-arm functional atom-transfer radical polymerization (ATRP) initiators were designed and selectively attached to lysozyme at the N-terminus via reductive amination. Site-specific, grafting from activator regenerated by electron transfer (ARGET) ATRP was carried out in phosphate buffer, and the reaction parameters were optimized to obtain polymer conjugates with predetermined molar mass and topology. The activity preservation under proteolytic and high-temperature conditions showed a clear dependence on the structure of the repeating unit and on the macromolecular architecture. These results highlighted the potential of PGMA as a poly(ethylene glycol) (PEG) alternative for the half-life extension of biotherapeutics. Moreover, this synthetic approach may inspire the design of a new class of protein-polymer conjugates through an optimal combination of macromolecular composition and topology

Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart

Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit+ CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit+ CSCs