Relationship of admission mean platelet volume with no-reflow in acute myocardial infarction treated with fibrinolysis

Platelets play a central role in the pathogenesis of acute coronary syndromes. Mean platelet volume (MPV) is a controversial issue in platelet reactivity, the extent of coronary artery disease, and response to reperfusion therapy. Thus, we sought to determine the relationship of admission MPV and no-reflow in patients with acute STsegment elevation myocardial infarction (STEMI) treated with fibrinolysis. 164 patients (143 male, 21 female) who had presented with STEMI treated with fibrinolysis and had undergone coronary angiography, were included in our study. Blood samples for MPV estimation were obtained on admission. All angiograms were assessed with respect to TIMI flow scale in infarct-related artery. Patients were divided in two groups: group 1 with reflow (TIMI=3, n = 42) and group 2 with no-reflow (TIMI<3, n = 122). Both univariate and multivariate analyses were performed on clinical and laboratory factors with relation to angiographic reperfusion. All characteristics were similar between the two groups. MPV was not associated with no-reflow (p=0.504). Multivariate analysis determined that RCA as an IRA was independent predictor of angiographic reperfusion. No-reflow phenomenon was observed significantly fewer when RCA was an IRA (odds ratio 2.6, 95% confidence interval 1.2 to 5.3, p=0.009). Our study showed that MPV is not related to angiographic reperfusion in patients with STEMI treated with fibrinolysis

The prevalence of sarcopenic obesity and its relationship with type 2 diabetes in a nursing home

OBJECTIVE: Diabetes mellitus (DM), sarcopenia, and sarcopenic obesity (SO) in the elderly were related to frailty, morbidity, and mortality. The aim of this study was to determine the contribution of diabetes mellitus to the prevalence of SO in a nursing home residents. SUBJECTS AND METHODS: This cross-sectional study included 397 old-aged (≥65 years) nursing home residents dwelling in Darulaceze Directorate Kayısdagı Campus of Istanbul. Exclusion criteria included <65 years of age, residing for less than a month, acute medical problems, and severe cognitive impairment (mini-mental state examination test score ≤10). Demographic characteristics, anthropometric measurements, nutritional status, and handgrip strength were evaluated for each participant. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People (EWGSOP) II criteria and obesity was defined with body mass index (BMI) ≥30 kg/m2. SO was the concomitant existence of sarcopenia and obesity together. RESULTS: Mean age of the participants was 77.95±7.94 (65-101) years (n=397). The prevalence of probable sarcopenia was significantly higher in non-obese patients when compared to obese (48.1% vs. 29.3%, p=0.014), which was similar after the exclusion of malnourished residents. In DM patients (n=63), the prevalence of obesity, probable sarcopenia and sarcopenic obesity were 30.2%, 42.2%, and 13.3%, which were 20.4%, 43.2%, and 6.5% in non-DM residents, respectively. CONCLUSIONS: Although they did not reach statistical significance, obesity and sarcopenic obesity were more prevalent among diabetic patients in a nursing home