Cultural and academic barriers toward physician-scientist (MD-PhD) careers: A mixed methods study

AbstractIn Saudi Arabia, there is yet to be a single MD-PhD program established despite calls for its implementation. Herein, we assess students’ and stakeholders’ perceived barriers and opinions towards the implementation of such a program. A mixed-method design was used. For the quantitative part, a sample of 190 medical students completed a pre-validated survey that addressed procedural, bureaucratic, and environmental challenges to the implementation of the program. In addition, three semi-structured interviews with stakeholders had been carried out to address the implementation of an MD-PhD track. While the semi-structured interviews resulted in a wide array of responses, most students indicated that limited funding (55.7%) and predicted high workload (63.2%) were amongst the most significant hurdles to enrolling in an MD-PhD if offered to do so. In addition, first-generation students and female students were less likely to encourage the establishment of such a program. This study reported multiple significant barriers to pursuing an MD-PhD track in the Kingdom of Saudi Arabia. The findings of this study reflect the complexity of implementing an MD-PhD program in the country and can be useful for concerning bodies to holistically consider predicted barriers that students may face when establishing an MD-PhD

Awareness of Parents about the Side Effects of Phenobarbital and the Management of Epileptic Children, Taif City, Saudi Arabia: A Cross-Sectional Study

Many children were suffering from neurological problems. One of these neurological problems is epilepsy, which causes seizures. Children with seizures were managed with different drugs. A drug like phenobarbital is used mainly for epilepsy. This study aimed to assess the awareness of parents about the side effects of phenobarbital and the management of epileptic children, describe the clinical presentation of children with epilepsy and assess the knowledge of parents about the management of epileptic children. A descriptive cross-sectional study was conducted among parents of children diagnosed with epilepsy. Online questionnaire survey distributed to parents of children with epilepsy. A total of 200 parents were included. The age group is 31-40 years old, 72(36%). Parents' knowledge about epilepsy was 98(49%). There were 104(52%) parents who reported seizures caused by low doses of Phenobarbital led to a loss of consciousness. Non-compliance with the required dose occurred majorly due to forgetting the dose 102(51%). The number of children with epilepsy was significantly associated with the awareness level of parents (P=0.0001). In addition, the awareness of parents was significant at the time of epilepsy diagnosis of children (P=0.01). An inadequate awareness among parents regarding the side effects of Phenobarbital, and there were gaps in their knowledge regarding other aspects of the condition and its management

Postoperative complications in living liver donors: A retrospective study, single-center experience in Saudi Arabia

Living donor liver transplantation (LDLT) offers life to patients with end-stage liver disease. The balance between the benefit to the recipient and the risk to the donor plays a central role in justifying LDLT. However, the incidence rates of complications posttransplant differ widely. This study is designed to identify postoperative complications in LDLT in a tertiary care center King Abdulaziz Medical City (KAMC). This was a retrospective cohort study. All donors at KAMC between January 2003 and December 2015 were reviewed through a hospital database and patient charts to determine the postoperative complications based on the modified Clavien classification system. All donors were relatives of the recipients and assessed before the surgery. A total of 101 donors underwent LDLT: 75 were male and 26 were female, with a mean age of 27.7 ± 6.6. The breakdown of specific surgical procedures was as follows: 65 (64.3%) donors underwent right hepatic lobectomy, 31 (30.6%) underwent left lateral hepatectomy, three (2.97%) underwent extended right hepatectomy with the inclusion of the middle hepatic vein, and two (1.98%) underwent left hepatectomy. Postoperative complications were determined in 20 patients (19.8%), but no mortality was observed. Complications were reported in 14 (21.5%) right and six (19.4%) left lateral hepatectomy donors. A total of 12 patients had Grade I complications, six patients had Grade II complications, and Grade III complications were reported in two cases. The most frequent complications were upper limb weakness to brachial plexus neuropathy and mild bile leak. Life-threatening complications in our center have not been reported in LDLT; however, some donors may experience postoperative morbidity, which usually were mild and had a good prognosis

Impact of clinical pharmacist intervention on clinical outcomes in the critical care unit, Taif City, Saudi Arabia: a retrospective study

(1) Objectives: Clinical pharmacists are now playing a significant role in hospitals aiming to reduce medication errors, adverse drug reactions, and healthcare costs. Therefore, the main objective of this study was to assess the interventions provided by a clinical pharmacist in the intensive care unit at the King Faisal Hospital in Taif city. (2) Methods: For this single-center retrospective study, patients were included from December 2021 to May 2022. In the present study, all the interventions of clinical pharmacists made over six months were included. The Intensive care unit (ICU) ward was covered by three clinical pharmacists, and the interventions made were categorized into four groups: (1) interventions related to indications; (2) interventions regarding safety; (3) interventions regarding dosing, and (4) miscellaneous. Descriptive statistics was applied to evaluate the results in the form of frequencies and percentages. Analysis was performed using the statistical package SPSS 20.0. (3) Results: Overall, a total of 404 interventions were recommended for 165 patients during the six- month period of study. Among them, 370 interventions (91.5%) were accepted by physicians. Among all the interventions, the majority were suggested regarding ‘indication’ (45.7%), including the addition of drugs, drugs with no indications, and duplication. The acceptance rate of clinical pharmacist intervention was 98.5%. (4) Conclusions: This retrospective study shows that clinical pharmacists played a critical role in optimizing drug therapy which could subsequently help to prevent drug-related issues and lower drug costs. More research is needed to do a thorough cost-benefit analysis

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population