Microwave-assisted biomimetic synthesis of hydroxyapatite using different sources of calcium

PMID = 2848256

Biomimetic synthesis of Ag, Zn or Co doped HA and coating of Ag, Zn or Co doped HA/fMWCNT composite on functionalized Ti

PMID = 3088977

3D porous collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite composite scaffolds for bone tissue engineering

PMID = 3018480

Ultrasound Sensitive Smart Polyvinyl Alcohol/Melamine/Tannic Acid Hydrogel

Problems such as hydrophilic properties of hydrogels, limited encapsulation of hydrophilic drugs, and unintended release amounts damage normal tissues and lead to overdose or repeated doses. This study investigates the development and characterization of drug carrier hydrogel formulations that can protect normal tissues. In this study, polyvinyl alcohol (PVA) hydrogel was synthesized by adding melamine (M) and tannic acid (TA) at different weight ratios to limit the hydrophilic properties of the hydrogel. In the analysis of the synthesized hydrogel, the efficiency of drug encapsulation increased from 60 to 90% as the TA content increased. The degree of swelling decreased from 73 to 63%. The contact angle increased from 10.15° to 62.27°, and the surface energy decreased. Drug release analysis was performed both in the presence of ultrasound (US) in a 40 kHz ultrasonic bath at 22 °C and without US at room temperature (22 °C). The drug release of Dox-loaded hydrogels was carried out in deionized water. Hydrogels release about two times more drug under ultrasound. After TA was added to the hydrogel, the drug release decreased by about 1.5 times. Successful results have been obtained with US, which is used to increase the amount of drug in the targeted area in a short time, accelerate the effect of the drug, and get faster results. The findings obtained as a result of all these characterizations and supported by FTIR provide promising contributions for controlled drug delivery systems. © 2023, King Fahd University of Petroleum ; Minerals

Polyvinyl Alcohol (PVA)-Based Stimuli-Sensitive Hydrogel Containing Carbon Nanotube (CNT) and Polyethylene Glycol (PEG)

The study focused on the synthesis of hydrogels using polyvinyl alcohol (PVA) and polyethylene glycol (PEG) as primary components and containing various proportions of carbon nanotubes (CNTs). The findings revealed that the hydrogels containing CNTs exhibited an increase in hydrophobic properties, with the average contact angle increasing from 14.77% (%PVA/PEG/DOX) to 73.73% (%PVA/PEG/CNT/DOX) and the swelling degree decreasing from 95 to 81%. Measurements using FTIR analysis and the observation of a decrease in surface free energy confirmed these findings. In addition, the hydrogels were observed to exhibit bioactivity. Drug release analysis was performed using ultrasound (US) at a frequency of 40 kHz and a temperature of 22 °C for periods of 15, 30, 45, and 60 min, excluding the use of ultrasound. The drug release assays revealed that even with the US effect, drug release decreased by approximately 6.71% as the CNT content increased. The results suggest that CNT-containing hydrogels have the potential to be valuable in drug delivery systems and could be a highly effective approach for drug delivery in the US. © King Fahd University of Petroleum ; Minerals 2024

Gender-related clinical and management differences in patients with chronic heart failure with reduced ejection fraction

Aim Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard