AMELIORATIVE ROLE OF BEE HONEY AND ROYAL JELLY AGAINST CISPLATIN INDUCED ALTERATION IN HEMATOLOGICAL PARAMETERS IN MALE WISTER ALBINO RAT

Objective: This study aims to investigate the ameliorative role of dietary bee honey and royal jelly against cisplatin-induced alterations in hematological parameters in male wistar albino rat.Methods: Male wistar albino rats of same age and weight were randomly divided into four groups; G, I: control group which was given 0.9% saline, G: II: cisplatin (7 mg/kg/d) was injected intraperitoneally for 15 d, G, III bee honey with royal jelly (500 mg/kg/d of honey and 100 mg/kg/d of royal jelly) fed orally daily for 15 d, G, IV: cisplatin (7 mg/kg/d) was injected intraperitoneally and honey (500 mg/kg/d) and royal Jelly (100 mg/kg/d) fed orally daily for 15 d. The hematological parameters like total number of white blood cells (WBCs), red blood cells (RBCs), platelets, % of hemoglobin (Hb), and mean values of packed cell volume (PCV), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were measured by using automated hematology system.Results: Cisplatin treated rats revealed a significant decrease in total number of white blood cells (WBCs), red blood cells (R. B. Cs), platelets, percentage of hemoglobin (Hb), and mean values of packed cell volume (PCV), corpuscular volume (MCV) and corpuscular hemoglobin concentration (MCHC) as compared to control group. Royal jelly and honey treated group of rats revealed a significant increase in all blood parameters compared to control group. Dietary bee honey with royal jelly along with cisplatin-treated rats revealed significant increas as compared to animals treated with cisplatin (G, II) and the computed significant valus for the above parameters are 10.00, 2.30, 8,54, 12.00, 35.00, 47.40 and 32,30 respectively.Conclusion: Bee honey and royal jelly could be used as dietary preventive natural products against cisplatin-induced hematological alterations during the treatment of cancer

A Novel Technique for Modeling Ecosystem Health Condition: A Case Study in Saudi Arabia

The present paper proposes a novel fuzzy-VORS (vigor, organization, resilience, ecosystem services) model by integrating fuzzy logic and a VORS model to predict ecosystem health conditions in Abha city of Saudi Arabia from the past to the future. In this study, a support vector machine (SVM) classifier was utilized to classify the land use land cover (LULC) maps for 1990, 2000, and 2018. The LULCs dynamics in 1990–2000, 2000–2018, and 1990–2018 were computed using delta (Δ) change and Markovian transitional probability matrix. The future LULC map for 2028 was predicted using the artificial neural network-cellular automata model (ANN-CA). The machine learning algorithms, such as random forest (RF), classification and regression tree (CART), and probability distribution function (PDF) were utilized to perform sensitivity analysis. Pearson’s correlation technique was used to explore the correlation between the predicted models and their driving variables. The ecosystem health conditions for 1990–2028 were predicted by integrating the fuzzy inference system with the VORS model. The results of LULC maps showed that urban areas increased by 334.4% between 1990 and 2018. Except for dense vegetation, all the natural resources and generated ecosystem services have been decreased significantly due to the rapid and continuous urbanization process. A future LULC map (2028) showed that the built-up area would be 343.72 km2. The new urban area in 2028 would be 169 km2. All techniques for sensitivity analysis showed that proximity to urban areas, vegetation, and scrubland are highly sensitive to land suitability models to simulate and predict LULC maps of 2018 and 2028. Global sensitivity analysis showed that fragmentation or organization was the most sensitive parameter for ecosystem health conditions. View Full-Tex

A farey wavelet-based mathematical model for biological series

<p>This work lies in the whole biomathematics framework which has as general goal the solving of biological problems with mathematical tools. The main objective of the present paper is to predict the transmembrane helices of proteins using wavelet denoising techniques. As a case of matter, we particularly highlight the interest in solving the problem of localizing these helices. Indeed, these helices play a vital role in the human body, notably in photosynthesis, respiration, neuronal signaling, immune response, absorption of nutrition, and have an important link with drugs as receptors coupled to many proteins. However, due to technical constraints, the crystallization of these helices remains very complex, which limits the exploration of their structure [27]. To overcome these difficulties, different prediction tools have been developed, initially based on hydrophobicity. In this paper, we serve the Farey wavelet as a last alternative mother wavelet constructed in [4] to develop a mathematical model suitable for protein series description. We precisely apply a new type of wavelets constructed recently in [4] to localize the and/or predict the position of the transmembrane proteins alpha-helices in a coronavirus strain. The results are compared to existing works for performance, accuracy, and efficiency.</p&gt

SUPERPAVE design mixture performance evaluation using Epolene modifier for cold semi-arid climatic region of Saudi Arabia

Purpose: To evaluate the superpave design performance using Epolene (EE-2) as modifier, since SUPERPAVE design is a modified and sophisticated aspect as compared to previous mix design for asphalt mixtures. This is primarily due to the fact that superpave design mix also takes into consideration properties of materials beside asphalt. Design/methodology/approach: This study was conducted using Epolene (EE-2) as modifier in order to evaluate the performance of SUPERPAVE suitability for construction of roads in Alfaraa campus (King Khalid University) Abha, in Asir Province of Saudi Arabia. Glow number test, dynamic modulus test and indirect tensile strength test were conducted to evaluate the performance of EE-2 modifier against the control mixture. Findings: The mixture modified with EE-2 gave better performance in terms of temperature-based performance and resistance to moisture damage. Also, larger values of E*/sinφ were obtained for EE-2 modified mixture at various loading frequencies and temperature in comparison to control mixture. Research limitations/implications: The Epolene modifier successfully enhances and improves the SUPERPAVE mixture performance. Further studies are required to evaluate the performance of EE-2 modifier at much lower temperature ranges. Practical implications: The results of the study allow us to recommend the investigated asphalt mixture for applied for the construction of roads in the Alfaraa (new campus of King Khalid University), Abha, Asir province, Saudi Arabia. Originality/value: A modified asphalt mixture has been proposed that has better performance at higher and lower temperatures. The developed asphalt mixture is more resistant to moisture damage than the compared to control mixture

Evaluation the Effect of Microwave Radiation on Gram Positive and Negative Bacteria

Using microwave oven nowadays has become necessary due to the need for speed in our daily activities. It is widely used in hating, thawing, and even cooking of food. It has been also used in sterilization and decontamination of food from microorganisms. This study aimed to evaluate thermal and non-thermal effect of a regular house holding microwave oven on Staphylococcus aureus and Escherichia coli. Bacterial suspension is exposed to microwave radiations in different strength and durations and compared to unexposed cultures. During microwave treatment, non-thermal effect is evaluated by putting the suspension crushed ice. The results indicate that the viability of both gram positive and negative was highly reduced with thermal effect of microwave radiations, leading to complete inactivation at three minutes. Non-thermal microwave radiations were also able to cause change in the microbial viability of both tested organisms on at least two-exposure occasion. The evaluation of antibiotic susceptibility before and after microwave radiations treatment indicate that antibiotic resistance was highly increased to tested antibiotics specially after three-minute exposure, except for Staphylococcus aureus to Amoxicillin, which became more sensitive. Microwave radiations reported to have a strong activity in eliminating the number of microbes but, it may have an important role in development of antibiotic resistance that should not be ignored

The Role of Biopolymer-Based Materials in Obstetrics and Gynecology Applications: A Review

Biopolymers have gained tremendous attention in many daily life applications, including medical applications, in the past few years. Obstetrics and gynecology are two fields dealing with sensitive parts of the woman’s body and her newborn baby, which are normally associated with many issues such as toxicity, infections, and even gene alterations. Medical professions that use screening, examination, pre, and post-operation materials should benefit from a better understanding of each type of material’s characteristics, health, and even environmental effects. The underlying principles of biopolymer-based materials for different obstetric and gynecologic applications may discover various advantages and benefits of using such materials. This review presents the health impact of conventional polymer-based materials on pregnant women’s health and highlights the potential use of biopolymers as a safer option. The recent works on utilizing different biopolymer-based materials in obstetric and gynecologic are presented in this review, which includes suture materials in obstetric and gynecologic surgeries, cosmetic and personal care products, vaginal health, and drug delivery; as well as a wound dressing and healing materials. This review highlights the main issues and challenges of biopolymers in obstetric and gynecologic applications