Letrozole as an adjunct treatment in antagonist cycles that previously failed in poor responders

Objectives: To investigate whether adding letrozole in the early follicular phase of a gonadotropin-releasing hormone (GnRH) antagonist (GA) stimulation cycle improves in vitro fertilization (IVF) outcomes in poor responder patients. Material and methods: To be included in this study, patients had to have had at least one previous GA cycle and a subsequent GA cycle with added early follicular phase letrozole (LzGA). A total of 41 poor responder patients were identified based on the Bologna criteria. Results: The LzGA group had a lower dosage of follicular stimulating hormone (FSH) (p = 0.001), the duration of stimulation days (p = 0.015) and the duration of GnRH antagonist stimulation days (p = 0.033) when compared with controls. Comprehensive analysis of the cycle characteristics showed that the number of oocytes retrieved, the number of MII oocytes retrieved, the number of fertilized oocytes, and the fertilization rate were significantly higher in the LzGA cycle (p = 0.041, p = 0.019, p = 0.008, p = 0.01, respectively). The rate of cycle cancellation was lower in the LzGA group (24.4%) than in the GA group (48.8%), (p < 0.001). Although LzGA administration demonstrated a trend toward improved implantation and clinical pregnancy rates, this was an insignificant trend (p = 1.000, p = 0.177, respectively). Conclusions: Adjunctive letrozole administration seems to restore an IVF cycle by improving the cycle characteristics and reducing the total gonadotrophin dosage.

Sıçanlarda oluşturulmuş laparoskopi modelinde, farklı intraabdominal basınç protokollerinin oksidadif stres markerleri ve morfoloji üzerine olan etkileri

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.[Abstarct Not Available

A Rare Uterine Malformation: Asymmetric Septate Uterus

WOS: 000422778600015PubMed ID: 2864757

Effectiveness of a one-day laparoscopic suture course

###EgeUn###We aimed to determine the effectiveness of a one-day course on laparoscopic suturing skills development by performing a prospective study with obstetrics and gynaecology specialists. The course consisted of a theoretical portion describing the suturing technique basics and a practical portion consisting of box trainer suturing. Before and after the course, each trainee was given 10 min to introduce the suture material into the abdomen, properly position the needle using a needle holder, pass the suture through premarked points on the silicone pads and tie an intracorporeal knot. The procedures were video recorded and evaluated after the course. The results showed that there were statistically significant reductions in the needle holding, suture passing and knot tying times after completing the course. Overall, the one-day course was an effective training programme for improving a surgeon's laparoscopic suturing skills.IMPACT STATEMENT What is already known on this subject? Currently, many countries have centres that provide laparoscopic training as part of the medical residency education. However, a standardised training programme has not been implemented worldwide. What do the results of this study add? In this study, we pointed out the effectiveness of a one-day laparoscopic suturing course. A one-day suturing course is easy to implement, cheap and effective

Kornual Ektopik Gebelik Tedavisinde Histeroskopi Ve Vakum Aspirasyon: Olgu Sunumu

The management of cornual ectopic pregnancy involves systemic methotrexate, laparotomy with cornual resection or hysterectomy. A 35-year-old nullipar presented with an 4-weeks history of amenorrhea and a positive pregnancy test. A diagnostic laparoscopy after the transvaginal sonography revealed a right cornual ectopic pregnancy. The patient was treated with multiple methotrexate doses, but the gestational sac persisted. Through the operative hysteroscope, the gestataional sac was ruptured, and the embryo was removed from the right uterine cornu and evacuated with vacuum aspiration. Three weeks postoperatively, the patient's ;szlig;-human chorionic gonadotropin level was negative, and the transvaginal sonographic findings were normal. Combined hysteroscopy and vacuum aspiration in the treatment of cornual ectopic pregnancy after methotrexate treatment is a minimally invasive surgical procedure.Kornual gebelik, ektopik gebeliklerin %2-5'ini oluşturur ve bu da en riskli ektopik gebelik tiplerinden biridir. Tedavi seçenekleri sistemik methotrexate uygulaması, laparotomi ile kornual rezeksiyon veya histerektomidir. Jinekolojik endoskopide son iki dekaddaki önemli gelişmeler sonucu, günümüzde literatürde endoskopik tedavi uygulanan vaka takdimlerine de rastlanılmaktadır. Burada da 35 yaşında, nullipar, 4 haftalık adet gecikmesi olan, özel bir klinikde, isteğe bağlı, karman aspirasyonu ile başarısız bir gebelik terminasyonu girişimi sonucu kliniğimize başvuran, yapılan sonografik inceleme ve laparoskopi ile sağ kornual gebelik teşhisi konulan, uygulanan sistemik methotrexate tedavisine cevap vermeyen ve operatif histeroskopi + karman aspirasyon küretaj ile cerrahi tedavi uygulanan bir vaka sunulmaktadır

Unusual cause of acute abdominal pain in a postmenopausal woman: adnexal torsion

Adnexal torsion is an infrequent but significant cause of acute lower abdominal pain in women. While adnexal torsion is generally considered in premenopausal women presenting with acute abdominal pain and a pelvic mass, it is a rare cause of acute abdominal pain during postmenopausal period. The diagnosis of adnexal torsion is often challenging due to nonspesific clinical, laboratory and physical examination findings. Causes of adnexal torsion is also different in premenopausal and postmenopausal women. While a simple functional cyst is often the cause of torsion in premenopausal women, it is more rarely the cause in postmenopausal women. Adnexal torsion is a surgical emergency. The surgery of adnexal torsion is performed either via conventional exploratory laparotomy or laparoscopic surgery. Adnexal torsion in postmenopausal women should be considered not only in the setting of sudden onset pain, but also in long-term abdominal discomfort. In this article, we presented a case with adnexal torsion that rarely cause acute abdominal pain in postmenopausal women